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PROSITE documentation PDOC50808 [for PROSITE entry PS50808]

Zinc finger BED-type profile





Description

The BED finger which was named after the drosophila proteins BEAF and DREF, is found in one or more copies in cellular regulatory factors and transposases from plants, animals and fungi. The BED finger is an about 50 to 60 amino acid residues domain that contains a characteristic motif with two highly conserved aromatic positions, as well as a shared pattern of cysteines and histidines that is predicted to form a zinc finger. As diverse BED fingers are able to bind DNA, it has been suggested that DNA-binding is the general function of this domain [1].

Some proteins known to contain a BED domain are listed below:

  • Animal, fungal and plant AC1 and Hobo-like transposases.
  • Caenorhabditis elegans protein dpy-20, a predicted cuticular-gene transcriptional regulator.
  • Drosophila BEAF (boundary element-associated factor), which is thought to be involved in chromatin insulation.
  • Drosophila DREF, a transcriptional regulator for S-phase genes.
  • Tobacco 3AF1 and tomato E4/E8-BP1, which are light- and ethylene-regulated DNA binding proteins that contain two BED fingers [2,3].
Last update:

April 2002 / First entry.

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Technical section

PROSITE method (with tools and information) covered by this documentation:

ZF_BED, PS50808; Zinc finger BED-type profile  (MATRIX)


References

1AuthorsAravind L.
TitleThe BED finger, a novel DNA-binding domain in chromatin-boundary-element-binding proteins and transposases.
SourceTrends Biochem. Sci. 25:421-423(2000).
PubMed ID10973053

2AuthorsLam E. Kano-Murakami Y. Gilmartin P. Niner B. Chua N.H.
TitleA metal-dependent DNA-binding protein interacts with a constitutive element of a light-responsive promoter.
SourcePlant Cell 2:857-866(1990).
PubMed ID2152132
DOI10.1105/tpc.2.9.857

3AuthorsCoupe S.A. Deikman J.
TitleCharacterization of a DNA-binding protein that interacts with 5' flanking regions of two fruit-ripening genes.
SourcePlant J. 11:1207-1218(1997).
PubMed ID9225464



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