|PROSITE documentation PDOC50824 [for PROSITE entry PS50824]|
The DAPIN (Domain in Apoptosis and INterferon response) domain is an 80-100-residue domain which is found in the N-terminus of diverse vertebrate and vertebrate-specific viral proteins involved in apoptosis, cancer, inflammation, and immune response. The DAPIN domain can be found alone or in association with other domains [1,2,3] like CARD (see <PDOC50209>, NACHT, HIN-200 (see <PDOC50834>), LRR, SPRY, Caspase (see <PDOC00864>) or Zinc finger B-box (see <PDOC50119>). It has been proposed that the DAPIN domain might have an adaptor function, coupling apoptosis and immune disorders [1,2,3]. It has been shown that the DAPIN domain is a protein-protein interaction domain capable of binding to other DAPIN domains .
Secondary structure predictions have identified the DAPIN domain as mostly α-helical and it has been suggested that it could belong to the DEATH-domain-fold superfamily, which includes the CARD, the DEATH domain (DD) (see <PDOC50017>) and the DEATH effector domain (DED) (see <PDOC50168>) [1,2,3].
Proteins known to contain a DAPIN domain are listed below:
We developed a profile that covers the whole domain.Last update:
December 2001 / First entry.
PROSITE method (with tools and information) covered by this documentation:
|1||Authors||Staub E., Dahl E., Rosenthal A.|
|Title||The DAPIN family: a novel domain links apoptotic and interferon response proteins.|
|Source||Trends Biochem. Sci. 26:83-85(2001).|
|2||Authors||Pawlowski K., Pio F., Chu Z.-L., Reed J.C., Godzik A.|
|Title||PAAD - a new protein domain associated with apoptosis, cancer and autoimmune diseases.|
|Source||Trends Biochem. Sci. 26:85-87(2001).|
|3||Authors||Martinon F., Hofmann K., Tschopp J.|
|Title||The pyrin domain: a possible member of the death domain-fold family implicated in apoptosis and inflammation.|
|Source||Curr. Biol. 11:R118-R120(2001).|