PROSITE documentation PDOC50824 [for PROSITE entry PS50824]

DAPIN domain profile





Description

The DAPIN (Domain in Apoptosis and INterferon response) domain is an 80-100-residue domain which is found in the N-terminus of diverse vertebrate and vertebrate-specific viral proteins involved in apoptosis, cancer, inflammation, and immune response. The DAPIN domain can be found alone or in association with other domains [1,2,3] like CARD (see <PDOC50209>, NACHT, HIN-200 (see <PDOC50834>), LRR, SPRY, Caspase (see <PDOC00864>) or Zinc finger B-box (see <PDOC50119>). It has been proposed that the DAPIN domain might have an adaptor function, coupling apoptosis and immune disorders [1,2,3]. It has been shown that the DAPIN domain is a protein-protein interaction domain capable of binding to other DAPIN domains [1].

Secondary structure predictions have identified the DAPIN domain as mostly α-helical and it has been suggested that it could belong to the DEATH-domain-fold superfamily, which includes the CARD, the DEATH domain (DD) (see <PDOC50017>) and the DEATH effector domain (DED) (see <PDOC50168>) [1,2,3].

The DAPIN domain has also been called pyrin domain, pyrin N-terminal homology domain (PYD) or PAAD (after the protein families pyrin, AIM, ASC death-domain-like) [2,3].

Proteins known to contain a DAPIN domain are listed below:

  • Mammalian pyrin. Mutations in the human pyrin MEFV gene are the cause of familial Mediterranean fever. Pyrin localizes to the perinuclear cytoplasm and interacts with a putative Golgi transport protein.
  • Mammalian ASC (apoptosis-associated speck-like protein containing a CARD) or Pycard (PYD and CARD containing protein). It forms aggregates when apoptosis is induced by certain anti-tumor drugs.
  • Human NALP1 and NALP2 (NACHT-, LRR- and PYD-containing proteins).
  • Zebrafish caspases CASPY and CASPY2.
  • Mammalian HIN-200 family of hematopoietic interferon-inducible nuclear proteins. This family includes AIM2 (absent in melanoma 2), MNDA (myeloid nuclear differentiation antigen) and IFI16.
  • Rabbit myxoma virus M013L protein.
  • Rabbit fibroma virus GP013L protein.

We developed a profile that covers the whole domain.

Last update:

December 2001 / First entry.

Technical section

PROSITE method (with tools and information) covered by this documentation:

DAPIN, PS50824; DAPIN domain profile  (MATRIX)


References

1AuthorsStaub E., Dahl E., Rosenthal A.
TitleThe DAPIN family: a novel domain links apoptotic and interferon response proteins.
SourceTrends Biochem. Sci. 26:83-85(2001).
PubMed ID11166557

2AuthorsPawlowski K., Pio F., Chu Z.-L., Reed J.C., Godzik A.
TitlePAAD - a new protein domain associated with apoptosis, cancer and autoimmune diseases.
SourceTrends Biochem. Sci. 26:85-87(2001).
PubMed ID11166558

3AuthorsMartinon F., Hofmann K., Tschopp J.
TitleThe pyrin domain: a possible member of the death domain-fold family implicated in apoptosis and inflammation.
SourceCurr. Biol. 11:R118-R120(2001).
PubMed ID11250163



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