|PROSITE documentation PDOC50887 [for PROSITE entry PS50887]|
The GGDEF domain, which has been named after the conserved central sequence pattern GG[DE][DE]F is widespread in prokaryotes. It is typically present in multidomain proteins containing regulatory domains of signaling pathways or protein-protein or protein-ligand interaction modules, such as the response regulatory domain (see <PDOC50110)), the EAL domain (see <PDOC50883>), the PAS/PAC domain (see <PDOC50112>), the HAMP domain (see <PDOC50885>), the GAF domain, the FHA domain (see <PS50006>) or the TPR repeat. However a few single-domain proteins are also known. The GGDEF domain is involved in signal transduction and is likely to catalyze synthesis or hydrolysis of cyclic diguanylate (c-diGMP, bis(3',5')-cyclic diguanylic acid), an effector molecule that consists of two cGMP moieties bound head-to-tail [1,2,3].
Some proteins known to contain a GGDEF domain are listed below:
The profile we developed covers the entire GGDEF domain.Last update:
February 2003 / Text revised.
PROSITE method (with tools and information) covered by this documentation:
|1||Authors||Galperin M.Y., Nikolskaya A.N., Koonin E.V.|
|Title||Novel domains of the prokaryotic two-component signal transduction systems.|
|Source||FEMS Microbiol. Lett. 203:11-21(2001).|
|2||Authors||Ausmees N., Mayer R., Weinhouse H., Volman G., Amikam D., Benziman M., Lindberg M.|
|Title||Genetic data indicate that proteins containing the GGDEF domain possess diguanylate cyclase activity.|
|Source||FEMS Microbiol. Lett. 204:163-167(2001).|
|3||Authors||Pei J., Grishin N.V.|
|Title||GGDEF domain is homologous to adenylyl cyclase.|