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PROSITE documentation PDOC50926 [for PROSITE entry PS50926] |
The TRAM (after TRM2 and miaB) domain is a 60-70-residue-long module that is found in:
The TRAM domain can be found alone or in association with other domains, such as the catalytic biotin/lipoate synthase-like domain, the RNA methylase domain, the ribosomal S2 domain (see <PDOC00744>) and the eIF2-β domain. The TRAM domain is predicted to bind tRNA and deliver the RNA-modifying enzymatic domain to their targets [1].
Secondary structure prediction indicates that the TRAM domain adopts a simple β barrel fold. The conservation pattern of the TRAM domain consists primarily of small and hydrophobic residues that correspond to five β-strands in the predicted secondary structure [1].
The profile we developed covers the entire TRAM domain.
Last update:September 2003 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
1 | Authors | Anantharaman V. Koonin E.V. Aravind L. |
Title | TRAM, a predicted RNA-binding domain, common to tRNA uracil methylation and adenine thiolation enzymes. | |
Source | FEMS Microbiol. Lett. 197:215-221(2001). | |
PubMed ID | 11313137 |