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PROSITE documentation PDOC51016 [for PROSITE entry PS51016]

MyTH4 domain profile


The myosin tail homology 4 (MyTH4) domain is a ~150 amino acid module which has been identified in different branches of the myosin superfamily and in a microtubule motor protein from plants (kinesin-like calmodulin binding protein; KLCBP) [1]. The MyTH4 domain is found in one or two copies associated with other domains, such as myosin head, kinesin motor, FERM (see <PDOC00566>), PH (see <PDOC50003>), SH3 (see <PDOC50002>) and IQ (see <PDOC50096>). The function of the MyTH4 domain is presently unknown, although its presence in several different putative motor proteins raises the possibility that different motor proteins might share similar mechanisms for targeting or regulation [2].

The MyTH4 is predicted to be largely α-helical, interrupted by three or four turns. The MyTH4 domain contains four highly conserved regions designated MGD (consensus sequence L(K/R)(F/Y)MGDhP, LRDE (consensus LRDEhYCQhhKQHxxxN), RGW (consensus RGWxLh), and ELEA (RxxPPSxhELEA), where h indicates a hydrophobic residue and x is any residue [3].

The profile we developed covers the entire MyTH4 domain.

Last update:

September 2004 / First entry.

Technical section

PROSITE method (with tools and information) covered by this documentation:

MYTH4, PS51016; MyTH4 domain profile  (MATRIX)


1AuthorsChen Z.-Y. Hasson T. Kelley P.M. Schwender B.J. Schwartz M.F. Ramakrishnan M. Kimberling W.J. Mooseker M.S. Corey D.P.
TitleMolecular cloning and domain structure of human myosin-VIIa, the gene product defective in Usher syndrome 1B.
SourceGenomics 36:440-448(1996).
PubMed ID8884267

2AuthorsOliver T.N. Berg J.S. Cheney R.E.
TitleTails of unconventional myosins.
SourceCell. Mol. Life Sci. 56:243-257(1999).
PubMed ID11212352

3AuthorsChen Z.-Y. Hasson T. Zhang D.-S. Schwender B.J. Derfler B.H. Mooseker M.S. Corey D.P.
TitleMyosin-VIIb, a novel unconventional myosin, is a constituent of microvilli in transporting epithelia.
SourceGenomics 72:285-296(2001).
PubMed ID11401444

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