PROSITE documentation PDOC51069 [for PROSITE entry PS51069]GBP repeat profile
Interactions between Plasmodium falciparum merozoite and erythrocyte proteins are essential for the parasite's survival. One of the erythrocyte binding proteins is the gylcophorin binding protein (GBP-130), which contains 11 highly conserved 50-residue-long repeats. The GBP repeats have been shown to bind to the erythrocyte receptor glycophorin. It appears that a minimum of between 3.5 and 4.5 repeats is required for the protein to bind to the glycophorin matrix. A correlation between glycophorin binding and repeat number might exist. GBPH is a Plasmodium protein highly homologous to GBP-130. It carries only 8 repeats of 40 residues, which can be superimposed on amino acids 2-41 of the GBP repeats [1,2,3].
The profile we developed covers the entire GBP repeat.
Last update:January 2005 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Kochan J. Perkins M. Ravetch J.V. |
| Title | A tandemly repeated sequence determines the binding domain for an erythrocyte receptor binding protein of P. falciparum. | |
| Source | Cell 44:689-696(1986). | |
| PubMed ID | 3512098 |
| 2 | Authors | Nolte D. Hundt E. Langsley G. Knapp B. |
| Title | A Plasmodium falciparum blood stage antigen highly homologous to the glycophorin binding protein GBP. | |
| Source | Mol. Biochem. Parasitol. 49:253-264(1991). | |
| PubMed ID | 1775169 |
| 3 | Authors | Suarez J.E. Urquiza M. Curtidor H. Rodriguez L.E. Ocampo M. Torres E. Guzman F. Patarroyo M.E. |
| Title | A GBP 130 derived peptide from Plasmodium falciparum binds to human erythrocytes and inhibits merozoite invasion in vitro. | |
| Source | Mem. Inst. Oswaldo Cruz 95:495-501(2000). | |
| PubMed ID | 10904405 |
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