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PROSITE documentation PDOC51069

GBP repeat profile





Description

Interactions between Plasmodium falciparum merozoite and erythrocyte proteins are essential for the parasite's survival. One of the erythrocyte binding proteins is the gylcophorin binding protein (GBP-130), which contains 11 highly conserved 50-residue-long repeats. The GBP repeats have been shown to bind to the erythrocyte receptor glycophorin. It appears that a minimum of between 3.5 and 4.5 repeats is required for the protein to bind to the glycophorin matrix. A correlation between glycophorin binding and repeat number might exist. GBPH is a Plasmodium protein highly homologous to GBP-130. It carries only 8 repeats of 40 residues, which can be superimposed on amino acids 2-41 of the GBP repeats [1,2,3].

The profile we developed covers the entire GBP repeat.

Last update:

January 2005 / First entry.

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Technical section

PROSITE method (with tools and information) covered by this documentation:

GBP, PS51069; GBP repeat profile  (MATRIX)


References

1AuthorsKochan J. Perkins M. Ravetch J.V.
TitleA tandemly repeated sequence determines the binding domain for an erythrocyte receptor binding protein of P. falciparum.
SourceCell 44:689-696(1986).
PubMed ID3512098

2AuthorsNolte D. Hundt E. Langsley G. Knapp B.
TitleA Plasmodium falciparum blood stage antigen highly homologous to the glycophorin binding protein GBP.
SourceMol. Biochem. Parasitol. 49:253-264(1991).
PubMed ID1775169

3AuthorsSuarez J.E. Urquiza M. Curtidor H. Rodriguez L.E. Ocampo M. Torres E. Guzman F. Patarroyo M.E.
TitleA GBP 130 derived peptide from Plasmodium falciparum binds to human erythrocytes and inhibits merozoite invasion in vitro.
SourceMem. Inst. Oswaldo Cruz 95:495-501(2000).
PubMed ID10904405



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