PROSITE logo

PROSITE documentation PDOC51071 [for PROSITE entry PS51071]
RpiR-type HTH domain profile


Description

The rpiR-type HTH domain is a DNA-binding, helix-turn-helix (HTH) domain of about 75-80 amino acids present in prokaryotic regulators of transcription. The domain is named after Escherichia coli rpiR, also known as alsR, a repressor of the rpiB gene and the als operon, which encode proteins involved in sugar metabolism. The DNA-binding rpiR-type HTH domain occurs usually in the N-terminal part; the C-terminal part can contain a phosphosugar-binding SIS domain. Most rpiR-type HTH regulators are involved in sugar metabolism as transcription repressors, but some are activators [1,2,3].

Some proteins known to contain a rpiR-type HTH domain:

  • Escherichia coli rpiR, a transcription repressor of ripB, a ribose-phosphate isomerase, and of the als operon, involved in transport and metabolism of allose.
  • Pseudomonas aeruginosa hexR, a transcription repressor of the hex regulon, involved in sugar metabolism.
  • Bacillus subtilis glvR, a transcription activator of the glv operon, involved in transport and metabolism of maltose [3].

The profile we developed spans the entire rpiR-type HTH DNA-binding domain.

Last update:

January 2005 / First entry.

-------------------------------------------------------------------------------


Technical section

PROSITE method (with tools and information) covered by this documentation:

HTH_RPIR, PS51071; RpiR-type HTH domain profile  (MATRIX)


References

1AuthorsSorensen K.I. Hove-Jensen B.
TitleRibose catabolism of Escherichia coli: characterization of the rpiB gene encoding ribose phosphate isomerase B and of the rpiR gene, which is involved in regulation of rpiB expression.
SourceJ. Bacteriol. 178:1003-1011(1996).
PubMed ID8576032

2AuthorsKim C. Song S. Park C.
TitleThe D-allose operon of Escherichia coli K-12.
SourceJ. Bacteriol. 179:7631-7637(1997).
PubMed ID9401019

3AuthorsYamamoto H. Serizawa M. Thompson J. Sekiguchi J.
TitleRegulation of the glv operon in Bacillus subtilis: YfiA (GlvR) is a positive regulator of the operon that is repressed through CcpA and cre.
SourceJ. Bacteriol. 183:5110-5121(2001).
PubMed ID11489864



PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

Miscellaneous

View entry in original PROSITE document format
View entry in raw text format (no links)