We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.

PROSITE entry PS51082

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PURL: https://purl.expasy.org/prosite/signature/PS51082

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General information about the entry

Entry name [info]	WH2
Accession [info]	PS51082
Entry type [info]	MATRIX
Date [info]	01-FEB-2005 CREATED; 01-OCT-2013 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC51082
Associated ProRule [info]	PRU00406

Name and characterization of the entry

Description [info]

WH2 domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=20;
/DISJOINT: DEFINITION=PROTECT; N1=1; N2=20;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=5.1699438; R2=0.0172713; TEXT='NScore';
/CUT_OFF: LEVEL=0; SCORE=141; N_SCORE=7.6; MODE=1; TEXT='R';
/CUT_OFF: LEVEL=-1; SCORE=43; N_SCORE=5.9; MODE=1; TEXT='RR';
/DEFAULT: B0=*; B1=*; E0=*; E1=*; MM=*; II=*;

...

                A   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y
/I:         B0=-85; B1=-85; BM=-1; BD=-44;
/M: SY='D';  M= 12,-32, 14, -3,-36, 12,-14,-33,-10,-14,  7,  5,  6,  3,-15,  4, -6,-29,-34,-28; M0=-7;
/I:         MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='R';  M=-22,-36,-20, -3,-40,  1, 14,-37, -3,-36,-27, -1, -9,-13, 35,-21, -7,-33,-37,-31; M0=-16;
/I:         MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='S';  M=  8,-34, 14, -1,-38,  2,-16,-35,-12,-35,-25, 15,-30,  8,-17, 19, -4,-31,-36,-29; M0=-11;
/I:         MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='A';  M= 22,-33, 11, 11,-36,-28,-14,-33,-10,-12,-24,  5,  5,  8,-15,-17, -6,-13,-34,-28; M0=-9;
/I:         MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='L';  M=-49,-43,-72,-66,  0,-69,-55,-20,-64, 31, 10,-66,-61,  9,-59,-62,-47, -8,-42,-44; M0=-39;
/I:         MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='L';  M=-52,-46,-76,-70,  5,-75,-59,-20,-68, 30, 28,-72,-63,-54,-62,-69,-51,-29,-43,-45; M0=-45;
/I:         MM=-1; MI=-95; MD=-48; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='A';  M= 18,-32, 12, 14,-36,  3,-14,-33,  0,-12,-23,  1,-28,  1,-15,  4,-17,-29,-34,-27; M0=-9;
/I:         MM=0; MI=-94; MD=-105; IM=-9; II=-11; DM=-4; DD=-20;
/M: SY='Q';  M= 17,-43, 12, 17,-46,  0,-22,-44,-20,-43,-34,-19,-36, 24,-26, -1,-27,-39,-45,-37; M0=-17;
/I:         MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='I';  M=-59,-52,-69,-72,-56,-61,-65, 41,-72,-48,-48,-69,-64,-70,-68,-69,-60,-35,-60,-62; M0=-55;
/I:         MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='R';  M=-31,  7,-33, -5,-48,-39, 19,-44, 16,-11,-34,-26,-39, 16, 31,-30,-30,-40,-41,-38; M0=-21;
/I:         MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='Q';  M=  8,-33,-16,  3,-36,  2,-14,-33, 13,-33, -1,  7,-29, 24,  4,  4, -6,-29,-34,-28; M0=-10;
/I:         MM=-46; MI=-21; MD=-4; IM=0; II=-52; DM=-7; DD=-14;
/M: SY='G';  M= -8,-22, 12,  0,-26, 17, -4,-23, 11,-23,-14, -3,-18,  0, -6,  5,  8,-19,-25,-18; M0=-6;
/I:         MM=0; MI=-76; MD=-86; IM=-9; II=-11; DM=-1; DD=-48;
/M: SY='G';  M=-31,-39,-27,-30,-59, 35,-37,-57,  4,-57,-50, -2,-43,-34,-37,-11,-34,-48,-58,-53; M0=-31;
/I:         MM=-24; MI=-38; MD=-4; IM=-1; II=-36; DM=-7; DD=-14;
/M: SY='I';  M=  5,-11,-13, -7,-11,-19, -6, 16,  9,  1, -2, -9,-20, -4,  9, -9,  7, -5,-14,-10; M0=-3;
/I:         MM=0; MI=-76; MD=-86; IM=-9; II=-11; DM=-1; DD=-48;
/M: SY='I';  M=  3,  7, -8,-35, 12,-13,-24, 14, 14, -9, 14,-31,  5,-28,-30,-26,  6,  6,-23,-20; M0=-8;
/I:         MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='Q';  M= -8,-33, -3, -2,-36,-28,-14,-33, 22,-33,-24,-14,-29, 24, 14,  5,  0,-29,-35,-28; M0=-13;
/I:         MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='L';  M=-64,-56,-72,-73,-43,-63,-64,-40,-73, 34,-32,-73,-65,-66,-68,-74,-64,-48,-54,-58; M0=-53;
/I:         MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='K';  M=-44,-50,-56,-38,-60,-49,-26,-52, 32,-14,-41, -9,-48,-22, 27,-43,-40,-50,-45,-45; M0=-32;
/I:         MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='K';  M=-40,-48,-45,-33,-56,-46, 17,-50, 33,-46,-39,-32, 19,-21,  0, -5,-37,-47,-45,-43; M0=-28;
/I:         MM=0; MI=-95; MD=-105; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='V';  M=  6,-23,-50,-44,-25,-42,-33,  2,-40,-11,-16,-39,-43,-37,-39, -9, 21, 27,-31,-28; M0=-20;
/I:         E0=-10; E1=-10;

» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.

Total number of hits	126 in 101 different sequences
Number of true positive hits	126 in 101 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	30
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	80.77 %

Comments [info]

Taxonomic range [info]	Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info]	3
Matrix type [info]	protein_domain
Scaling database [info]	window20
Author [info]	PS_Langendijk_Genevaux
Feature key [info]	DOMAIN
Feature description [info]	WH2
Version [info]	4

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

101 sequences

ACTOA_DICDI (Q55DU3), ACTOB_DICDI (Q55DU1), ACTO_ENTHI  (O15602),

BIMA_BURTA  (Q2T6X7), COBL1_HUMAN (Q53SF7), COBL_DANRE  (E7F568), 
COBL_HUMAN  (O75128), COBL_MOUSE  (Q5NBX1), COBL_RAT(D3ZUI5), 
ESPN_HUMAN  (B1AK53), ESPN_MOUSE  (Q9ET47), ESPN_RAT(Q63618), 
INF2_HUMAN  (Q27J81), INF2_MOUSE  (Q0GNC1), INF2_XENLA  (Q6NTV6), 
INF2_XENTR  (Q0IHV1), JMY_DANRE   (Q6NVC9), JMY_HUMAN   (Q8N9B5), 
JMY_MOUSE   (Q9QXM1), JMY_XENTR   (A8E4X8), LAS17_YEAST (Q12446), 
LMOD1_HUMAN (P29536), LMOD1_MOUSE (Q8BVA4), LMOD1_RAT   (A0A0G2K0D3), 
LMOD2_CHICK (E1BTG2), LMOD2_HUMAN (Q6P5Q4), MTSS1_HUMAN (O43312), 
MTSS1_MOUSE (Q8R1S4), P78_NPVAC   (Q03209), PAN1_AJECN  (A6R7X5), 
PAN1_ASPCL  (A1CD74), PAN1_ASPFC  (B0YC95), PAN1_ASPFU  (Q4WG58), 
PAN1_ASPNC  (A2R180), PAN1_ASPOR  (Q2UDY8), PAN1_ASPTN  (Q0CPW4), 
PAN1_CANAL  (Q5AHB1), PAN1_CHAGB  (Q2H922), PAN1_COCIM  (Q1DQC1), 
PAN1_DEBHA  (Q6BNL1), PAN1_EMENI  (Q5B5B0), PAN1_LODEL  (A5DVD6), 
PAN1_NEOFI  (A1DC51), PAN1_PICGU  (A5DP36), PAN1_PICST  (A3LN86), 
PAN1_SCHPO  (Q10172), PXK_HUMAN   (Q7Z7A4), PXK_MOUSE   (Q8BX57), 
PXK_RAT (Q4FZZ1), RICKA_RICBR (Q1RI78), RICKA_RICFE (Q4UMI6), 
RICKA_RICMO (Q9AKP3), SCAR2_ARATH (Q5XPJ9), SCAR_DICDI  (Q54NF8), 
SCRL1_ORYSJ (Q84TX2), SCRL2_ORYSJ (Q5QNA6), SLOB1_DICDI (Q54TC3), 
SPIR2_DANRE (Q5U3H9), SPIR2_HUMAN (Q8WWL2), SPIR2_MOUSE (Q8K1S6), 
SPIR_DROME  (Q9U1K1), SPIR_DROPS  (Q29KT5), VASP_DICDI  (Q5TJ65), 
VP61_NPVOP  (O10270), VRP1_SCHPO  (Q9P6R1), VRP1_YEAST  (P37370), 
WASF1_BOVIN (Q0IIJ3), WASF1_HUMAN (Q92558), WASF1_MOUSE (Q8R5H6), 
WASF1_PONAB (Q5NVG8), WASF1_RAT   (Q5BJU7), WASF2_BOVIN (A2VDK6), 
WASF2_HUMAN (Q9Y6W5), WASF2_MOUSE (Q8BH43), WASF3_HUMAN (Q9UPY6), 
WASF3_MOUSE (Q8VHI6), WASH1_BOVIN (A7Z063), WASH1_CHICK (Q5ZKA6), 
WASH1_DICDI (Q54CK9), WASH1_MOUSE (Q8VDD8), WASH1_RAT   (B2RYF7), 
WASH1_XENTR (Q28DN4), WASH2_HUMAN (Q6VEQ5), WASH3_HUMAN (C4AMC7), 
WASL_BOVIN  (Q95107), WASL_HUMAN  (O00401), WASL_MOUSE  (Q91YD9), 
WASL_RAT(O08816), WASP_HUMAN  (P42768), WASP_MOUSE  (P70315), 
WHAMM_HUMAN (Q8TF30), WHAMM_MOUSE (Q571B6), WIPF1_HUMAN (O43516), 
WIPF1_MOUSE (Q8K1I7), WIPF1_RAT   (Q6IN36), WIPF2_HUMAN (Q8TF74), 
WIPF2_MOUSE (Q6PEV3), WIPF3_HUMAN (A6NGB9), WIPF3_MOUSE (P0C7L0), 
WIPF3_RAT   (Q9Z0G8), WSP1_SCHPO  (O36027)

» more

Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
False negative sequences

30 sequences

ACTO_ACACA  (P18281), COBL1_MOUSE (Q3UMF0), LMOD2_MOUSE (Q3UHZ5),

LMOD2_RAT   (A1A5Q0), LMOD3_DANRE (E7F7X0), LMOD3_HUMAN (Q0VAK6), 
LMOD3_MOUSE (E9QA62), MTSS2_HUMAN (Q765P7), MTSS2_MOUSE (Q6P9S0), 
PAN1_BOTFB  (A6S9N4), PAN1_NEUCR  (Q7SAT8), PAN1_PYRO7  (A4R8N4), 
PAN1_SCLS1  (A7EKZ0), PAN1_YARLI  (Q6C908), RICKA_RICCN (Q92H62), 
RICKA_RICRI (Q9AKJ0), SCAR1_ARATH (Q6AWX6), SCAR3_ARATH (Q9LP46), 
SCAR4_ARATH (Q5XPJ6), SPIR1_DANRE (Q1LYM3), SPIR1_HUMAN (Q08AE8), 
SPIR1_MACFA (Q4R707), SPIR1_MOUSE (Q52KF3), WASH1_CAEEL (O18195), 
WASH1_DANRE (A4IG59), WASH1_DROME (Q7JW27), WASH1_HUMAN (A8K0Z3), 
WASH1_XENLA (Q5U4A3), WASH4_HUMAN (A8MWX3), WASH6_HUMAN (Q9NQA3)

» more

PDB
[Detailed view]

27 PDB

pdb_00002a3z; pdb_00002a40; pdb_00002a41; pdb_00002d1k; pdb_00002vcp; pdb_00003m3n; pdb_00003mn5; pdb_00003mn7; pdb_00003p8c; pdb_00003tu5; pdb_00003ue5; pdb_00004efh; pdb_00004jhd; pdb_00004n78; pdb_00004rwt; pdb_00005wfn; pdb_00005ypu; pdb_00006jbk; pdb_00006jcu; pdb_00006jh8; pdb_00006jh9; pdb_00006uhc; pdb_00007usc; pdb_00007usd; pdb_00007use; pdb_00008rv2; pdb_00009azp
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