|PROSITE documentation PDOC51082 [for PROSITE entry PS51082]|
The WH2 (WASP-Homology 2, or Wiskott-Aldrich homology 2) domain is an ~18 amino acids actin-binding motif. This domain was first recognized as an essential element for the regulation of the cytoskeleton by the mammalian Wiskott-Aldrich syndrome protein (WASP) family. WH2 proteins occur in eukaryotes from yeast to mammals, in insect viruses, and in some bacteria. The WH2 domain is found as a modular part of larger proteins; it can be associated with the WH1 or EVH1 domain (see <PDOC50229>) and with the CRIB domain (see <PDOC50108>), and the WH2 domain can occur as a tandem repeat. The WH2 domain binds actin monomers and can facilitate the assembly of actin monomers into newly forming actin filaments [1,2,3,4].
Some proteins known to contain a WH2 domain:
The profile we developed covers the entire WH2 domain.Last update:
February 2005 / First entry.
PROSITE method (with tools and information) covered by this documentation:
|1||Authors||Machesky L.M. Insall R.H. Volkman L.E.|
|Title||WASP homology sequences in baculoviruses.|
|Source||Trends Cell Biol. 11:286-287(2001).|
|Title||Are beta-thymosins WH2 domains?|
|Source||FEBS Lett. 573:231-232(2004).|
|3||Authors||Paunola E. Mattila P.K. Lappalainen P.|
|Title||WH2 domain: a small, versatile adapter for actin monomers.|
|Source||FEBS Lett. 513:92-97(2002).|
|4||Authors||Quinlan M.E. Heuser J.E. Kerkhoff E. Mullins R.D.|
|Title||Drosophila Spire is an actin nucleation factor.|