PROSITE documentation PDOC51111 [for PROSITE entry PS51111]REJ domain profile
The REJ domain is an extracellular module of ~700 amino acids, which is found associated with others domains, such as EGF (see <PDOC00021>), the GPS proteolytic cleavage site (see <PDOC50221>), C-type lectin (see <PDOC00537>), SUEL-type lectin (see <PDOC50228>), LRR, LDL-A, PLAT (see <PDOC50095>) or PKD (see <PDOC50093>) [1,2]. Although its function is unknown, the REJ domain has been shown to be required for cleavage to occur at the GPS [3]. It has been proposed that the REJ domain might function in ion transport homeostasis [1].
Some proteins known to contain a REJ domain are listed below:
- Sea urchin sperm receptor for egg jelly 1 (suREJ1). It binds to the fucose sulfate polymer of egg jelly to induce the sperm acrosome reaction [4].
- Sea urchin sperm receptor for egg jelly 2 (suREJ2). It is present over the entire sperm plasma membrane, but is concentrated over the sperm mitochondrion [4].
- Sea urchin sperm receptor for egg jelly 3 (suREJ3). It localizes over the acrosomal vesicle [4].
- Human autosomal dominant polycystic kidney disease protein polycystin-1. It is thought to be part of a plasma membrane signaling/ion channel complex involved in maintaining the terminally differentiated state of renal tubular epithelial cells.
- Mammalian polycystic kidney disease and receptor for egg jelly related protein (PKDREJ), a testis-specific protein whose function is unknown [5].
- Mammalian polycystic kidney disease 1-like 1 protein (PKD1L1),
The profile we developed covers the entire REJ domain.
Last update:November 2005 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Moy G.W. Mendoza L.M. Schulz J.R. Swanson W.J. Glabe C.G. Vacquier V.D. |
| Title | The sea urchin sperm receptor for egg jelly is a modular protein with extensive homology to the human polycystic kidney disease protein, PKD1. | |
| Source | J. Cell Biol. 133:809-817(1996). | |
| PubMed ID | 8666666 |
| 2 | Authors | Sandford R. Sgotto B. Aparicio S. Brenner S. Vaudin M. Wilson R.K. Chissoe S. Pepin K. Bateman A. Chothia C. Hughes J. Harris P. |
| Title | Comparative analysis of the polycystic kidney disease 1 (PKD1) gene reveals an integral membrane glycoprotein with multiple evolutionary conserved domains. | |
| Source | Hum. Mol. Genet. 6:1483-1489(1997). | |
| PubMed ID | 9285785 |
| 3 | Authors | Qian F. Boletta A. Bhunia A.K. Xu H. Liu L. Ahrabi A.K. Watnick T.J. Zhou F. Germino G.G. |
| Title | Cleavage of polycystin-1 requires the receptor for egg jelly domain and is disrupted by human autosomal-dominant polycystic kidney disease 1-associated mutations. | |
| Source | Proc. Natl. Acad. Sci. U.S.A. 99:16981-16986(2002). | |
| PubMed ID | 12482949 | |
| DOI | 10.1073/pnas.252484899 |
| 4 | Authors | Galindo B.E. Moy G.W. Vacquier V.D. |
| Title | A third sea urchin sperm receptor for egg jelly module protein, suREJ2, concentrates in the plasma membrane over the sperm mitochondrion. | |
| Source | Dev. Growth Differ. 46:53-60(2004). | |
| PubMed ID | 15008854 |
| 5 | Authors | Hughes J. Ward C.J. Aspinwall R. Butler R. Harris P.C. |
| Title | Identification of a human homologue of the sea urchin receptor for egg jelly: a polycystic kidney disease-like protein. | |
| Source | Hum. Mol. Genet. 8:543-549(1999). | |
| PubMed ID | 9949214 |
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