PROSITE documentation PDOC51114 [for PROSITE entry PS51114]F-box-associated (FBA) domain profile
F-box proteins have a bipartite structure: they contain a carboxy-terminal domain that interacts with substrates and a 42-48 amino-acid F-box domain (see <PDOC50181>) which binds to the protein Skp1. A subset of F-box proteins is characterized by a ~180-residue carboxy-terminal region, which has been called the F-box-associated (FBA) domain [1,2]. A FBA domain has also been identified in the catfish, tilapia, and zebrafish nonspecific cytotoxic cell receptor proteins (NCCRP-1), which do not contain the F-box domain. NCCRP-1 may function as an antigen recognition molecule and, as such, may participate in innate immunity in teleosts [2,3]. The FBA domain is likely to be a glycoprotein-binding module [4,5].
The FBA domain is an ellipsoid composed of a ten-stranded antiparallel β-sandwich with two α-helices (see <PDB:1UMH>) [5].
Some proteins known to contain a FBA domain are listed below:
- Mammalian F-box only protein 2.
- Mammalian F-box only protein 6.
- Mammalian F-box only protein 17.
- Mammalian F-box only protein 27.
- Mammalian F-box only protein 44.
- Teleostian NCCRP-1.
- Caenorhabditis elegans hypothetical protein C14B1.3.
The profile we developed covers the entire FBA domain.
Last update:July 2005 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Winston J.T. Koepp D.M. Zhu C. Elledge S.J. Harper J.W. |
| Title | A family of mammalian F-box proteins. | |
| Source | Curr. Biol. 9:1180-1182(1999). | |
| PubMed ID | 10531037 |
| 2 | Authors | Ilyin G.P. Serandour A.-L. Pigeon C. Rialland M. Glaise D. Guguen-Guillouzo C. |
| Title | A new subfamily of structurally related human F-box proteins. | |
| Source | Gene 296:11-20(2002). | |
| PubMed ID | 12383498 |
| 3 | Authors | Jaso-Friedmann L. Peterson D.S. Gonzalez D.S. Evans D.L. |
| Title | The antigen receptor (NCCRP-1) on catfish and zebrafish nonspecific cytotoxic cells belongs to a new gene family characterized by an F-box-associated domain. | |
| Source | J. Mol. Evol. 54:386-395(2002). | |
| PubMed ID | 11847564 | |
| DOI | 10.1007/s00239-001-0027-8 |
| 4 | Authors | Yoshida Y. Tokunaga F. Chiba T. Iwai K. Tanaka K. Tai T. |
| Title | Fbs2 is a new member of the E3 ubiquitin ligase family that recognizes sugar chains. | |
| Source | J. Biol. Chem. 278:43877-43884(2003). | |
| PubMed ID | 12939278 | |
| DOI | 10.1074/jbc.M304157200 |
| 5 | Authors | Mizushima T. Hirao T. Yoshida Y. Lee S.J. Chiba T. Iwai K. Yamaguchi Y. Kato K. Tsukihara T. Tanaka K. |
| Title | Structural basis of sugar-recognizing ubiquitin ligase. | |
| Source | Nat. Struct. Mol. Biol. 11:365-370(2004). | |
| PubMed ID | 14990996 | |
| DOI | 10.1038/nsmb732 |
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