The TAF homology (TAFH) or Nervy homology region 1 (NHR1) domain is a domain
of 95-100 amino acids present in eukaryotic proteins of the MTG/ETO family and
whereof the core ~75-80 residues occur in TAF proteins. The transcription
initiation TFIID complex is composed of TATA binding protein (TBP) and a
number of TBP-associated factors (TAFs). The TAFH/NHR1 domain is named after
fruit fly TATA-box-associated factor 110 (TAF110), human TAF105 and TAF130,
and the fruit fly protein Nervy, which is a homologue of human MTG8/ETO [1,2].
The human eight twenty-one (ETO or MTG8) and related myeloid transforming gene
products MTGR1 and MTG16 as well as the Nervy protein contain the NHR1-4
domains. The NHR1/TAFH domain occurs in the N-terminal part of these proteins,
while a MYND-type zinc finger (see <PDOC50865>) forms the NHR4 domain . The
TAFH/NHR1 domain can be involved in protein-protein interactions, e.g in
MTG8/ETO with HSP90 and Gfi-1 [4,5].
Some proteins known to contain a TAFH/NHR1 domain:
Mammalian MTG8/ETO protein, which is involved in the t(8;21) form of acute
myeloid leukemia and is an inhibitor of C/EBP β in early adipogenesis.
Mammalian myeloid transforming gene (MTG) or eight twenty-one (ETO)
proteins, which can mediate the protein complex formation among nuclear
corepressors, chromatin-modifying enzymes (HDACs), and transcription
Drosophila melanogaster Nervy protein, a homologue of MTG8/ETO which is
involved in neuronal development during segmentation of Drosophila embryos.
Drosophila melanogaster transcription initiation factor TFIID 110 kDa
subunit (TAF110) and mammalian homologue (TAFII130/135), which can interact
with Sp1 and which may be a transcriptional coactivator.
The profile we developed covers the entire TAFH/NHR1 domain.
May 2005 / First entry.
PROSITE method (with tools and information) covered by this documentation:
Kitabayashi I. Ida K. Morohoshi F. Yokoyama A. Mitsuhashi N. Shimizu K. Nomura N. Hayashi Y. Ohki M.
The AML1-MTG8 leukemic fusion protein forms a complex with a novel member of the MTG8(ETO/CDR) family, MTGR1.
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