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PROSITE documentation PDOC51119

TAFH/NHR1 domain profile





Description

The TAF homology (TAFH) or Nervy homology region 1 (NHR1) domain is a domain of 95-100 amino acids present in eukaryotic proteins of the MTG/ETO family and whereof the core ~75-80 residues occur in TAF proteins. The transcription initiation TFIID complex is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). The TAFH/NHR1 domain is named after fruit fly TATA-box-associated factor 110 (TAF110), human TAF105 and TAF130, and the fruit fly protein Nervy, which is a homologue of human MTG8/ETO [1,2]. The human eight twenty-one (ETO or MTG8) and related myeloid transforming gene products MTGR1 and MTG16 as well as the Nervy protein contain the NHR1-4 domains. The NHR1/TAFH domain occurs in the N-terminal part of these proteins, while a MYND-type zinc finger (see <PDOC50865>) forms the NHR4 domain [3]. The TAFH/NHR1 domain can be involved in protein-protein interactions, e.g in MTG8/ETO with HSP90 and Gfi-1 [4,5].

Some proteins known to contain a TAFH/NHR1 domain:

  • Mammalian MTG8/ETO protein, which is involved in the t(8;21) form of acute myeloid leukemia and is an inhibitor of C/EBP β in early adipogenesis.
  • Mammalian myeloid transforming gene (MTG) or eight twenty-one (ETO) proteins, which can mediate the protein complex formation among nuclear corepressors, chromatin-modifying enzymes (HDACs), and transcription factors.
  • Drosophila melanogaster Nervy protein, a homologue of MTG8/ETO which is involved in neuronal development during segmentation of Drosophila embryos.
  • Drosophila melanogaster transcription initiation factor TFIID 110 kDa subunit (TAF110) and mammalian homologue (TAFII130/135), which can interact with Sp1 and which may be a transcriptional coactivator.

The profile we developed covers the entire TAFH/NHR1 domain.

Last update:

May 2005 / First entry.

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Technical section

PROSITE method (with tools and information) covered by this documentation:

TAFH, PS51119; TAFH/NHR1 domain profile  (MATRIX)


References

1AuthorsKitabayashi I. Ida K. Morohoshi F. Yokoyama A. Mitsuhashi N. Shimizu K. Nomura N. Hayashi Y. Ohki M.
TitleThe AML1-MTG8 leukemic fusion protein forms a complex with a novel member of the MTG8(ETO/CDR) family, MTGR1.
SourceMol. Cell. Biol. 18:846-858(1998).
PubMed ID9447981

2AuthorsCalabi F. Cilli V.
TitleCBFA2T1, a gene rearranged in human leukemia, is a member of a multigene family.
SourceGenomics 52:332-341(1998).
PubMed ID9790752

3AuthorsDavis J.N. McGhee L. Meyers S.
TitleThe ETO (MTG8) gene family.
SourceGene 303:1-10(2003).
PubMed ID12559562

4AuthorsKomori A. Sueoka E. Fujiki H. Ishii M. Kozu T.
TitleAssociation of MTG8 (ETO/CDR), a leukemia-related protein, with serine/threonine protein kinases and heat shock protein HSP90 in human hematopoietic cell lines.
SourceJpn. J. Cancer Res. 90:60-68(1999).
PubMed ID10076566

5AuthorsMcGhee L. Bryan J. Elliott L. Grimes H.L. Kazanjian A. Davis J.N. Meyers S.
TitleGfi-1 attaches to the nuclear matrix, associates with ETO (MTG8) and histone deacetylase proteins, and represses transcription using a TSA-sensitive mechanism.
SourceJ. Cell. Biochem. 89:1005-1018(2003).
PubMed ID12874834
DOI10.1002/jcb.10548



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