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PROSITE documentation PDOC50865 |
The MYND-type zinc finger was called after the three best characterized members of the family (MYeloid translocation protein 8 (MTG8/ETO), Nervy protein and Deaf-1) [1]. In MTG8 and Bop proteins this domain is important for the recruitment of a repressive complexe containing histone deacetylase (HDAC) activity [2,3]. In M2-type chronic leukemia where AML1 is fused to MTG8, AML1, normaly a transcriptional activator, is converted into a transcriptional repressor. The MYND domain of MTG8 is essential for this conversion and seems to function by recruiting the nuclear co-repressor N-CoR/mSin3A and HDACs complexes to DNA sites specified by AML1 [2].
The MYND-type zinc finger contains 8 amino acids that can coordinate 2 zinc atoms.
Some proteins containing a MYND-type zinc finger are listed below:
The profile and the pattern we developed cover the whole domain.
Last update:January 2003 / First entry.
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PROSITE methods (with tools and information) covered by this documentation:
1 | Authors | Gross C.T. McGinnis W. |
Title | DEAF-1, a novel protein that binds an essential region in a Deformed response element. | |
Source | EMBO J. 15:1961-1970(1996). | |
PubMed ID | 8617243 |
2 | Authors | Gelmetti V. Zhang J. Fanelli M. Minucci S. Pelicci P.G. Lazar M.A. |
Title | Aberrant recruitment of the nuclear receptor corepressor-histone deacetylase complex by the acute myeloid leukemia fusion partner ETO. | |
Source | Mol. Cell. Biol. 18:7185-7191(1998). | |
PubMed ID | 9819405 |
3 | Authors | Gottlieb P.D. Pierce S.A. Sims R.J. Yamagishi H. Weihe E.K. Harriss J.V. Maika S.D. Kuziel W.A. King H.L. Olson E.N. Nakagawa O. Srivastava D. |
Title | Bop encodes a muscle-restricted protein containing MYND and SET domains and is essential for cardiac differentiation and morphogenesis. | |
Source | Nat. Genet. 31:25-32(2002). | |
PubMed ID | 11923873 | |
DOI | 10.1038/ng866 |
4 | Authors | Scarr R.B. Sharp P.A. |
Title | PDCD2 is a negative regulator of HCF-1 (C1). | |
Source | Oncogene 21:5245-5254(2002). | |
PubMed ID | 12149646 | |
DOI | 10.1038/sj.onc.1205647 |