PROSITE documentation PDOC50865Zinc finger MYND-type signature and profile
The MYND-type zinc finger was called after the three best characterized members of the family (MYeloid translocation protein 8 (MTG8/ETO), Nervy protein and Deaf-1) [1]. In MTG8 and Bop proteins this domain is important for the recruitment of a repressive complexe containing histone deacetylase (HDAC) activity [2,3]. In M2-type chronic leukemia where AML1 is fused to MTG8, AML1, normaly a transcriptional activator, is converted into a transcriptional repressor. The MYND domain of MTG8 is essential for this conversion and seems to function by recruiting the nuclear co-repressor N-CoR/mSin3A and HDACs complexes to DNA sites specified by AML1 [2].
The MYND-type zinc finger contains 8 amino acids that can coordinate 2 zinc atoms.
Some proteins containing a MYND-type zinc finger are listed below:
- Mammalian MTG8/ETO protein. MTG8 is part of a high molecular weight complex that contains co-repressors and HDACs.
- Drosophila Nervy protein, a homologue of MTG8.
- Animal Deformed epidermal autoregulatory factor 1 (Deaf-1). It was first identified in drosophila as a sequence-specific DNA binding protein that was isolated as a putative cofactor of the Hox protein Deformed (Dfd).
- Vertebrate Bop protein. In mouse it is expressed specifically in cardiac and muscle precursors before differentiation of these lineages.
- Mammalian programmed cell death protein 2 (PDCD2/RP8). It interacts with N-CoR/mSin3A complexes and with Host cell factor 1 (HCF1), a component of the C1 complex [4].
- Adenovirus 5 E1A-binding protein (BS69). It binds to the transactivation domain of the adenovirus type 5 E1A 32 kda protein (289R) and inhibits its transactivating activity.
The profile and the pattern we developed cover the whole domain.
Last update:January 2003 / First entry.
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PROSITE methods (with tools and information) covered by this documentation:
| 1 | Authors | Gross C.T. McGinnis W. |
| Title | DEAF-1, a novel protein that binds an essential region in a Deformed response element. | |
| Source | EMBO J. 15:1961-1970(1996). | |
| PubMed ID | 8617243 |
| 2 | Authors | Gelmetti V. Zhang J. Fanelli M. Minucci S. Pelicci P.G. Lazar M.A. |
| Title | Aberrant recruitment of the nuclear receptor corepressor-histone deacetylase complex by the acute myeloid leukemia fusion partner ETO. | |
| Source | Mol. Cell. Biol. 18:7185-7191(1998). | |
| PubMed ID | 9819405 |
| 3 | Authors | Gottlieb P.D. Pierce S.A. Sims R.J. Yamagishi H. Weihe E.K. Harriss J.V. Maika S.D. Kuziel W.A. King H.L. Olson E.N. Nakagawa O. Srivastava D. |
| Title | Bop encodes a muscle-restricted protein containing MYND and SET domains and is essential for cardiac differentiation and morphogenesis. | |
| Source | Nat. Genet. 31:25-32(2002). | |
| PubMed ID | 11923873 | |
| DOI | 10.1038/ng866 |
| 4 | Authors | Scarr R.B. Sharp P.A. |
| Title | PDCD2 is a negative regulator of HCF-1 (C1). | |
| Source | Oncogene 21:5245-5254(2002). | |
| PubMed ID | 12149646 | |
| DOI | 10.1038/sj.onc.1205647 |
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