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| PROSITE documentation PDOC50865 |
Zinc finger MYND-type signature and profile
The MYND-type zinc finger was called after the three best characterized members of the family (MYeloid translocation protein 8 (MTG8/ETO), Nervy protein and Deaf-1) [1]. In MTG8 and Bop proteins this domain is important for the recruitment of a repressive complexe containing histone deacetylase (HDAC) activity [2,3]. In M2-type chronic leukemia where AML1 is fused to MTG8, AML1, normaly a transcriptional activator, is converted into a transcriptional repressor. The MYND domain of MTG8 is essential for this conversion and seems to function by recruiting the nuclear co-repressor N-CoR/mSin3A and HDACs complexes to DNA sites specified by AML1 [2].
The MYND-type zinc finger contains 8 amino acids that can coordinate 2 zinc atoms.
Some proteins containing a MYND-type zinc finger are listed below:
- Mammalian MTG8/ETO protein. MTG8 is part of a high molecular weight complex that contains co-repressors and HDACs.
- Drosophila Nervy protein, a homologue of MTG8.
- Animal Deformed epidermal autoregulatory factor 1 (Deaf-1). It was first identified in drosophila as a sequence-specific DNA binding protein that was isolated as a putative cofactor of the Hox protein Deformed (Dfd).
- Vertebrate Bop protein. In mouse it is expressed specifically in cardiac and muscle precursors before differentiation of these lineages.
- Mammalian programmed cell death protein 2 (PDCD2/RP8). It interacts with N-CoR/mSin3A complexes and with Host cell factor 1 (HCF1), a component of the C1 complex [4].
- Adenovirus 5 E1A-binding protein (BS69). It binds to the transactivation domain of the adenovirus type 5 E1A 32 kda protein (289R) and inhibits its transactivating activity.
The profile and the pattern we developed cover the whole domain.
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html --------------------------------------------------------------------------------.
Last update:January 2003 / First entry.
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PROSITE methods (with tools and information) covered by this documentation:
| 1 | Authors | Gross C.T. McGinnis W. |
| Title | DEAF-1, a novel protein that binds an essential region in a Deformed response element. | |
| Source | EMBO J. 15:1961-1970(1996). | |
| PubMed ID | 8617243 |
| 2 | Authors | Gelmetti V. Zhang J. Fanelli M. Minucci S. Pelicci P.G. Lazar M.A. |
| Title | Aberrant recruitment of the nuclear receptor corepressor-histone deacetylase complex by the acute myeloid leukemia fusion partner ETO. | |
| Source | Mol. Cell. Biol. 18:7185-7191(1998). | |
| PubMed ID | 9819405 |
| 3 | Authors | Gottlieb P.D. Pierce S.A. Sims R.J. Yamagishi H. Weihe E.K. Harriss J.V. Maika S.D. Kuziel W.A. King H.L. Olson E.N. Nakagawa O. Srivastava D. |
| Title | Bop encodes a muscle-restricted protein containing MYND and SET domains and is essential for cardiac differentiation and morphogenesis. | |
| Source | Nat. Genet. 31:25-32(2002). | |
| PubMed ID | 11923873 | |
| DOI | 10.1038/ng866 |
| 4 | Authors | Scarr R.B. Sharp P.A. |
| Title | PDCD2 is a negative regulator of HCF-1 (C1). | |
| Source | Oncogene 21:5245-5254(2002). | |
| PubMed ID | 12149646 | |
| DOI | 10.1038/sj.onc.1205647 |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
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