|PROSITE documentation PDOC51156 [for PROSITE entry PS51156]|
The ELM2 (EGL-27 and MTA1 homology) domain was first described in Egl-27, a Caenorhabditis elegans protein that plays a fundamental role in patterning during embryonic development . Most ELM2 domain-containing proteins also possess a SANT domain, implying a structural and/or functional relationship between these two motifs. Many proteins containing an ELM2 domain are known components of characterized transcription- and chromatin-regulatory complexes containing one or more histone deacetylases (HDACs). The evolutionarily conserved ELM2 domain has been shown to function as a transcriptional repression domain through recruitment of HDAC activity .
Some proteins known to contain a ELM2 domain are listed below:
The profile we developed covers the entire extended ELM2 domain .Last update:
October 2005 / First entry.
PROSITE method (with tools and information) covered by this documentation:
|1||Authors||Solari F. Bateman A. Ahringer J.|
|Title||The Caenorhabditis elegans genes egl-27 and egr-1 are similar to MTA1, a member of a chromatin regulatory complex, and are redundantly required for embryonic patterning.|
|2||Authors||Ding Z. Gillespie L.L. Paterno G.D.|
|Title||Human MI-ER1 alpha and beta function as transcriptional repressors by recruitment of histone deacetylase 1 to their conserved ELM2 domain.|
|Source||Mol. Cell. Biol. 23:250-258(2003).|