We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.

PROSITE entry PS51185

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PURL: https://purl.expasy.org/prosite/signature/PS51185

Direct ScanProsite submission

General information about the entry

Entry name [info]	WHEP_TRS_2
Accession [info]	PS51185
Entry type [info]	MATRIX
Date [info]	01-MAR-2006 CREATED; 13-FEB-2019 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC00614
Associated ProRule [info]	PRU00531

Name and characterization of the entry

Description [info]

WHEP-TRS domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=57;
/DISJOINT: DEFINITION=PROTECT; N1=1; N2=57;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.4966421; R2=0.0045687; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=6066.1040039; R2=3.2124279; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=1315; H_SCORE=10290; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=877; H_SCORE=8883; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-18; D=-100; I=-100; B1=-500; E1=-500; MI=-255; MD=-255; IM=-255; DM=-255;

...

                A   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y
/I:         B1=0; BI=-255; BD=-255;
/M: SY='D';  M= -1,-49, 46, 16,-51,  0,-19,-22, 10,-28,-16,-16,-21, 27, -4, 35, -1,-37,-57,-42;
/M: SY='L';  M= 17,-35,-21,-14,-36,-12,-31, 18, -2, 23,-24,-40, 17,-29, 11, -2,-21, 20,-52,-31;
/M: SY='A';  M= 43,-45,  4, 20,-46,-22,-37,-38, 28,  2,  5, -4,-22,  8,-29,  3,-16,-22,-53,-42;
/M: SY='E';  M= 37,-23, 31, 41,-53,-33,-36,-41,-22,-34,-41,-22, 35, 17,-36,  6, -3,-19,-57,-46;
/M: SY='L';  M=  1,-45,-35,-31,-13,-56,-45, 30,-27, 64, -5,-51,-37,-43,-28,-45,-23, -3,-48,-31;
/M: SY='Y';  M=-15,-51,-27, 29, 11,-47,-29,-38,-23, -1, -4, -4,-46, 28, 40, -6,  6,-28, 18, 47;
/M: SY='E';  M= 21,-47, 32, 36,-48,-32, -9,-42, 20, -1,-36, 21,-41, 20,-29,  6, -9,-27,-56,-42;
/M: SY='E';  M= 35,-19,-30, 37,-49,-39,-35,-16, 29,-17,-35,-20,-41, 30, 15, 10,-30,-15,-52,-42;
/M: SY='V';  M=-29,-47,-58,-53,-27,-61,-58, 64,-47, -1,-15,-52,-52,-49,-10,-44,-30, 66,-56,-35;
/M: SY='A';  M= 36,-47, 12, 27,-52,-38,-34,-22, 32,-45,-39, 16,-40, 23, 14,-21, 15,-24,-55,-43;
/M: SY='E';  M= 32,-23, -1, 53,-51,-40,-23,-33, 11,-20,-37,-31,-39, 44,-28,  2,-14, -8,-54,-43;
/M: SY='Q';  M=-35,-59,-31,-12,-57,-44,-23,-47, -6,-30,  3,-27,-43,112, 10,-26,-37,-50,-46, -7;
/M: SY='G';  M= 11,-50,  7,-44,-57, 86,-13,-62,-43,-59,-49,-25,-43,-40,-50,-24,-41,-55,-51,-51;
/M: SY='D';  M=  3,-50, 70, 48,-55,-31,-29,-51,-26,-27,-46, 47,-41,-19,-20,-28,-15,-40,-65,-46;
/M: SY='K';  M= 10,-46,-41,  4,-17,-49,  3, -5, 42, 37,-21,-33,-47,-23,-16,-36,-19, 20,-50,-35;
/M: SY='V';  M=-17,-42,-58,-52,-29,-59,-61, 29,-50,-14,-17,-53,-53,-52,-52,-41,-27, 86,-62,-37;
/M: SY='R';  M=-11,-57,-38,-26,-52,-50,-28,-57,  2,-50,-39,-32,-50, 12,101,-34,-40,-50,-51,-38;
/M: SY='K';  M= -5,-52, 41, 34,-56,-12,-31,-53, 45,-51,-43,-24,-39, 41, 16,  3,-12,-38,-55,-43;
/M: SY='L';  M=-13,-44,-59,-51,-18,-59,-44,  7,-52, 77,  4,-57,-58,-45,-50,-50,-37, -7,-47,-30;
/M: SY='K';  M=-38,-53,-31,-17,-54,-45,-33,-55, 96,-53,-41,-23,-39,-15, 17,-32,-33,-50,-48,-41;
/M: SY='A';  M= 57,-42,-34, 15,-51, 16,-39,-42,-33,-44,-16,-22,-40, 16,-38, 29,  4,-13,-53,-45;
/M: SY='E';  M= 31,-48, 17, 43,-56,-16,-33,-51, 39,-50,-42,-13,-38, 33,-13, 10,-15,-44,-53,-44;
/M: SY='K';  M=-36,-51, 26,-20,-55, 17,-32,-55, 76,-55,-44, 28,-40, -5,  1,-29, -7,-51,-53,-43;
/M: SY='A';  M= 75,-39,-19,-24,-51,-20,-42,-42,-11,-44,-38,-16, -6,-32,-39, 13,  0,-27,-53,-46;
/M: SY='P';  M= 16,-50, 35, 23,-56,-35,-36,-51, 16,-54,-46,-27, 61,-26,-33, 44,-26,-46,-57,-47;
/I:         I=-26; MD=-65;
/M: SY='K';  M= -6,-51, -6,  1,-55,-41,-35,-51, 71,-51,-10,-26, 22, 20, -3, 17, -9,-47,-52,-43; D=-26;
/I:         I=-26; MI=0; MD=-65; IM=0; DM=-65;
/M: SY='E';  M= 20,-49, 35, 42,-52,-13,-34,-12,-28,-38,-39,  2, -6, 37,-35, 14, -3, -9,-57,-44;
/M: SY='E';  M=  3,-50, 42, 49,-49,-41,-35,-21,  6,-19,-36,-29,-40, 39,-30,-29,  7, 16,-58,-42;
/M: SY='W';  M=-18,-48,-57,-53,-27,-57,-58, 66,-49,  1,-17,-49,-50,-48,-53,-19,  9, 46, 67,-31;
/I:         I=-30; MI=0; MD=-77; IM=0; DM=-77;
/M: SY='D';  M= -1,-51, 74, 10,-57,-30,-31,-53, 40,-53,-47,  4,-40, 19,-24,-22, 16,-48,-62,-44;
/M: SY='A';  M= 42,-48, 25, 34,-54,-29,-37,-36, 19,-48,-41,-30, 33,  3, -8,  7,-30,-21,-55,-46;
/M: SY='A';  M= 68,-43,-27, 57,-54,-33,-38,-47,-28,-46,-40,-35,-38,-14,-13,-13,-30,-35,-53,-47;
/M: SY='V';  M=-30,-43,-59,-54,-28,-61,-61, 44,-51,-13,-16,-53,-53,-52,-53,-43,-27, 83,-60,-36;
/M: SY='A';  M= 45,-45, -3,  8,-53, -7,-35,-46, 43,-48,-40, 33,-41, 17,-24,-15,  0,-24,-54,-44;
/M: SY='K';  M=-15,  9,-30, 33,-46,-47,-35,  2, 60,-13, 23,-12,-40, 19, -8,-32,  9,-26,-51,-40;
/M: SY='L';  M=-42,-44,-60,-52,-16,-61,-43, -7,-53, 81, 16,-59,-59,-46,-50,-53,-38,-15,-46,-28;
/M: SY='L';  M=-41,-46,-49,-41,-23,-55,-40,-15, 33, 69,-11, -7,-54,-37,-33,-31,-36,-17,-48,-32;
/M: SY='A';  M= 42,-46, 25, 36,-53,-35,-35,-31, 21,-47,-41,-24,-39, 20,-29, 31,-15,-27,-55,-44;
/M: SY='L';  M=-12,-46,-54,-46,-21,-35,-40,-14,-20, 70, 10,-51,-56,-39, 19,-46,-38,-20,-46,-13;
/M: SY='K';  M=-38,-52,-29,  3,-54,-45,-33,-55, 96,-53,-41,-23,-38,-15,  0,-32,-33,-50,-48,-41;
/M: SY='K';  M= 46,-44,-35, -8,-46,-31,-18,-38, 47,-10, 14, 18,-43,-13,  8,-26, -9,-13,-52,-41;
/M: SY='Q';  M=-13,-51, 17, 39,-41,-42,  1,-37, 14,-17,-36,  4,-40, 67,-25, 10,  7,-20,-54,-39;
/M: SY='Y';  M=-32,-50,-52,-49, 29,-56,-28,-19,-18, 50,-15,-51,-58,-41,-42,-46,-39,-16,-21, 86;
/M: SY='K';  M= 16,-19,-16, 30,-54, 17,-36,-53, 68,-41,-42,-27,-39, -5,-15, -3,-32,-46,-50,-44;
/M: SY='E';  M= 27,-47, 23, 31,-51, 15, 22,-47,  2,-21,-40,-16,-22, -2,-11, 14, 12,-36,-56,-42;
/M: SY='V';  M= 33,-44, 13,-34,-38,-15,-43,-12, 29, 17, 14,-37,-46,-35,-27,-32,-14, 33,-54,-39;
/M: SY='T';  M=-10,-45, -1, 53,-48,-14,-36,-32,-10,-42, 13,-26,-35,-10,-34,  5, 66,-29,-58,-43;
/M: SY='G';  M=-22,-51,-36, 10,-48, 73,-42,-19,  0,  1,-38,-20,-43,-14,-25, -7,-39,-44,-50,-46;
/M: SY='K';  M=  6,-49,-29, 28,-53, -8,-34,-38, 44,-48,-40,-10, -7, 37, 16, 22, -2,-16,-52,-42;
/M: SY='D';  M=-27,-52, 64, 30,-47,-34, -2,-42,-30, 13,-37,-25, 24, 11,-21, 14, -4,-42,-60,-41;
/M: SY='Y';  M=  4,-53,-42,-28,  8,-15,  4,-31, 12,-28,-32,-25, -1, 26, -7,-23,-11,-12, 65, 74;
/M: SY='K';  M=  6,-50, -8, -2, 10,-43,-38,-35, 61,-17,-37,-32, 46,-15,-18, -9, -6,-23, -9,-37;
/M: SY='P';  M= 38,-50,-41,-19,-18,-24,-43,-21, 26,-43,-37,-39, 73,-25,-19,-19,-20,  6,-51,-28;
/M: SY='P';  M= -3,-51, 28,-13,-32, 44,-43,-15,-28,-10,-37, -9, 53,-39,-46,-16,-34, 12,-55,-46;
/M: SY='C';  M= 22, 38,  8,-31,-49, 12,-30,-42, 17,-29,-24,  8,  4, 10,-34, 29, 12,-11,-57,-44;
/M: SY='P';  M= 28,  3,-39,-35,-46, -8,-42, -1,  2,-13,-34, -7, 49, -1,-21, 18, 23,-11,-54,-44;
/M: SY='P';  M= 17,-50,-39,-32,  8,-25,-41,-40, 23,-45,-39,-20, 76,-18,-10, 10,  7, -9,-50,-41;
/I:         E1=0; IE=-255; DE=-255;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.

Total number of hits	43 in 32 different sequences
Number of true positive hits	43 in 32 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	6
Matrix type [info]	protein_domain
Scaling database [info]	window20
Author [info]	V_Lesaux
Feature key [info]	DOMAIN
Feature description [info]	WHEP-TRS
Version [info]	6

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

32 sequences

GARS_BOMMO  (Q04451), GARS_CAEEL  (Q10039), GARS_DROME  (Q9VUK8),

GARS_HUMAN  (P41250), GARS_MOUSE  (Q9CZD3), GARS_PONAB  (Q5RBL1), 
GARS_RAT(Q5I0G4), HARS1_BOVIN (Q2KI84), HARS1_DANRE (E9QI36), 
HARS1_HUMAN (P12081), HARS1_MESAU (P07178), HARS1_MOUSE (Q61035), 
HARS1_PONAB (Q5R4R2), SYEP_CRIGR  (Q7SIA2), SYEP_DROME  (P28668), 
SYEP_HUMAN  (P07814), SYEP_MOUSE  (Q8CGC7), SYGM1_ARATH (O23627), 
SYH_SCHPO   (O43011), SYMC_BOVIN  (Q2T9L8), SYMC_HUMAN  (P56192), 
SYMC_MOUSE  (Q68FL6), SYMC_XENLA  (Q6PF21), SYNC1_ARATH (Q9SW96), 
SYNC3_ARATH (Q9SSK1), SYWC_BOVIN  (P17248), SYWC_DANRE  (Q6PBS3), 
SYWC_HUMAN  (P23381), SYWC_MOUSE  (P32921), SYWC_PONAB  (Q5R4J1), 
SYWC_RABIT  (P23612), SYWC_RAT(Q6P7B0)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

30 PDB

pdb_00001d2d; pdb_00001fyj; pdb_00001r1b; pdb_00001r6t; pdb_00001x59; pdb_00002azx; pdb_00002djv; pdb_00002lw7; pdb_00002pme; pdb_00002pmf; pdb_00002q5h; pdb_00002q5i; pdb_00002quh; pdb_00002qui; pdb_00002quj; pdb_00002quk; pdb_00002zt5; pdb_00002zt6; pdb_00002zt7; pdb_00002zt8; pdb_00002zxf; pdb_00004g85; pdb_00004kqe; pdb_00004phc; pdb_00004x5o; pdb_00005e6m; pdb_00005ujj; pdb_00006o76; pdb_00008yor; pdb_00008yp1
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