|PROSITE documentation PDOC51204 [for PROSITE entry PS51204]|
The helicase/SANT-associated (HSA) domain is a predicted DNA-binding domain of ~75 amino acids , which is found in the eukaryotic SRCAP/p400/DOM and SNF2/brahma families . While each family has the core sequences that define the HSA domain, they each also have additional sequences that distinguish these families from one another. For example, the sequence HWDY(L/C)EEEM(Q/V) is found in the SRCAP/p400/DOM family, whereas the sequence HQE(Y/F)LNSILQ is found in the SNF2 /brahma family . In addition to the SANT and helicase (see <PDOC51192>) domains, the HSA domain is also found in association with bromo (see <PDOC00550>) .
Some proteins known to contain a HSA domain are listed below :
The profile we developed covers the entire HSA domain.Last update:
May 2006 / First entry.
PROSITE method (with tools and information) covered by this documentation:
|1||Authors||Doerks T., Copley R.R., Schultz J., Ponting C.P., Bork P.|
|Title||Systematic identification of novel protein domain families associated with nuclear functions.|
|Source||Genome Res. 12:47-56(2002).|
|2||Authors||Eissenberg J.C., Wong M., Chrivia J.C.|
|Title||Human SRCAP and Drosophila melanogaster DOM are homologs that function in the notch signaling pathway.|
|Source||Mol. Cell. Biol. 25:6559-6569(2005).|