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PROSITE documentation PDOC51224 [for PROSITE entry PS51224]

MVP (vault) repeat profile





Description

Vaults are large ribonucleoprotein particles, composed of three different proteins and one or more small vault RNA (vRNA) molecules packed into barrel-shaped assemblies that are found in all higher eukaryotes. Their main component is major vault protein (MVP) or lung resistance-related protein (LRP), which is implicated in resistance to cancer therapy and correlates with poor prognosis.

The N-terminal part of MVP contains ~8 copies of the vault repeat or MVP repeat in tandem. The MVP repeat is composed of ~53 amino acids and forms a structural part of the vault wall. The C-terminal part of MVP may be involved in oligomerization and be located in the vault cap, while the MVP repeats in the N-terminal part can be packed like staves in a barrel to form the vault wall. The 3D structure of the repeat forms a fold that consists of a three stranded (B) antiparallel β-sheet in a unique topology B2-B1-B3 and two loops (see <PDB:1Y7X>). MVP repeats can be interaction-mediating modules, as MVP repeats 3 and 4 bind vault poly(ADP-ribose) polymerase (VPARP/PARP-4) (see <PDOC51059>), which is one of the other vault proteins [1].

The profile we developed covers the entire MVP repeat.

Last update:

July 2006 / First entry.

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Technical section

PROSITE method (with tools and information) covered by this documentation:

MVP, PS51224; MVP (vault) repeat profile  (MATRIX)


Reference

1AuthorsKozlov G. Vavelyuk O. Minailiuc O. Banville D. Gehring K. Ekiel I.
TitleSolution structure of a two-repeat fragment of major vault protein.
SourceJ. Mol. Biol. 356:444-452(2006).
PubMed ID16373071
DOI10.1016/j.jmb.2005.11.064



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