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PROSITE documentation PDOC51289 [for PROSITE entry PS51289]

Cysteine-rich GLG1 repeat





Description

The Golgi apparatus protein 1 (GLG1), which is located in Golgi cisterns of various cell types, can bind fibroblast growth factor and E-selectin. Sixteen cysteine-rich GLG1 repeats form the core of the protein and are located in the lumen. The C-terminal part of GLG1 is composed of a transmembrane region and a short cytoplasmic tail. The Cys-rich GLG1 repeat is a ~60 amino acid module that contains 4 Cys residues, which can form intrachain disulfide bridges [1,2]. Homologues of the vertebrate GLG1/Golgi sialoglycoprotein MG-160 (Mg160)/E-selectin ligand 1 (ESL1)/cysteine-rich fibroblast growth factor receptor 1 (CFR1)/latent transforming growth factor-β complex protein 1 (LTCP-1) have been found in insects and the nematode Caenorhabditis elegans.

The profile we developed covers the entire cysteine-rich GLG1 repeat.

Last update:

January 2007 / First entry.

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Technical section

PROSITE method (with tools and information) covered by this documentation:

GLG1_C_RICH, PS51289; Cysteine-rich GLG1 repeat profile  (MATRIX)


References

1AuthorsBurrus L.W. Zuber M.E. Lueddecke B.A. Olwin B.B.
TitleIdentification of a cysteine-rich receptor for fibroblast growth factors.
SourceMol. Cell. Biol. 12:5600-5609(1992).
PubMed ID1448090

2AuthorsKawano J. Nakayama T. Kotani T. Matsubayashi H. Yamamoto M.T. Suganuma T.
TitleIdentification and characterization of an insect homologue of the vertebrate Golgi apparatus protein 1 (MG-160/cysteine-rich fibroblast growth factor receptor/E-selectin ligand-1/latent transforming growth factor-beta complex protein-1) with a Golgi-specific monoclonal antibody.
SourceHistochem. Cell Biol. 117:381-389(2002).
PubMed ID12029485
DOI10.1007/s00418-002-0402-6



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