|PROSITE documentation PDOC51303 [for PROSITE entry PS51303]|
The PET domain is a ~110 amino acid motif in the N-terminal part of LIM domain proteins. The domain was described in Drosophila proteins involved in cell differentiation and is named after Prickle, Espinas and Testin. PET domain proteins contain about three zinc-binding LIM domains (see <PDOC00382>) and are found among metazoans. The PET domain has been suggested to play a role in protein-protein interactions with proteins involved in planar polarity signaling or organisation of the cytoskeleton .
Some proteins known to contain a PET domain:
The profile we developed covers the entire PET domain.Last update:
March 2007 / First entry.
PROSITE method (with tools and information) covered by this documentation:
|1||Authors||Gubb D., Green C., Huen D., Coulson D., Johnson G., Tree D., Collier S., Roote J.|
|Title||The balance between isoforms of the prickle LIM domain protein is critical for planar polarity in Drosophila imaginal discs.|
|Source||Genes Dev. 13:2315-2327(1999).|