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PROSITE documentation PDOC51316 [for PROSITE entry PS51316]

Neuroblastoma breakpoint family (NBPF) domain profile


Proteins of the neuroblastoma breakpoint family (NBPF) contain a highly conserved domain of unknown function, which has been named the NBPF domain. The NBPF domain is present in multiple copies in NBPF proteins and once, with lower homology, in mammalian myomegalin (PDE4DIP), a protein localized in the Golgi/centrosomal area which functions as an anchor to localize components of the cyclic adenosine monophosphate-dependent pathway to this region. The number of NBPF repeat copies is highly expanded in humans, reduced in African great apes, further reduced in orangutan and Old World monkeys, single-copy in nonprimate mammals, and absent in nonmammalian species. The NBPF domain that is found as a singly copy in nonprimate mammals is the likely ancestral domain. The implications of the resemblance of NBPF proteins to myomegalin remain obscure as no functional properties have been ascribed to the NBPF domains. NBPF domains are typically built of two exons [1,2].

The profile we developed covers the entire NBPF domain.

Last update:

May 2007 / First entry.


Technical section

PROSITE method (with tools and information) covered by this documentation:

NBPF, PS51316; Neuroblastoma breakpoint family (NBPF) domain profile  (MATRIX)


1AuthorsVandepoele K. Van Roy N. Staes K. Speleman F. van Roy F.
TitleA novel gene family NBPF: intricate structure generated by gene duplications during primate evolution.
SourceMol. Biol. Evol. 22:2265-2274(2005).
PubMed ID16079250

2AuthorsPopesco M.C. MacLaren E.J. Hopkins J. Dumas L. Cox M. Meltesen L. McGavran L. Wyckoff G.J. Sikela J.M.
TitleHuman lineage-specific amplification, selection, and neuronal expression of DUF1220 domains.
SourceScience 313:1304-1307(2006).
PubMed ID16946073

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