|PROSITE documentation PDOC51237 [for PROSITE entry PS51317]|
ABC transporters belong to the ATP-Binding Cassette (ABC) superfamily which use the hydrolysis of ATP to energize diverse biological systems. It forms one of the largest of all protein families with a diversity of physiological functions (see <PDOC00185>) [1,2]. Several studies have shown that there is a correlation between the functional characterisation and the phylogenetic classification of the ABC cassette [2,4]. More than 50 families have been described based on a phylogenetic and functional classification [2,3,4] [E1].
Some ABC transporter families on which we developed a profile are listed below.
Active import transport system components:
Active export transport system components:
Each family profile was built on a discriminating region either in the ABC cassette or in the C-terminal region.Last update:
June 2009 / Text revised.
PROSITE methods (with tools and information) covered by this documentation:
|1||Authors||Holland I.B. Cole S.P.C. Kuchler K. Higgins C.F.|
|Source||(In) ABC proteins from bacteria to man, Academic Press, San Diego, (2003).|
|2||Authors||Saurin W. Hofnung M. Dassa E.|
|Title||Getting in or out: early segregation between importers and exporters in the evolution of ATP-binding cassette (ABC) transporters.|
|Source||J. Mol. Evol. 48:22-41(1999).|
|Title||ABC transporters: physiology, structure and mechanism -- an overview.|
|Source||Res. Microbiol. 152:205-210(2001).|
|4||Authors||Dassa E. Bouige P.|
|Title||The ABC of ABCS: a phylogenetic and functional classification of ABC systems in living organisms.|
|Source||Res. Microbiol. 152:211-229(2001).|