ABC transporters belong to the ATP-Binding Cassette (ABC) superfamily which
use the hydrolysis of ATP to energize diverse biological systems. It forms one
of the largest of all protein families with a diversity of physiological
functions (see <PDOC00185>) [1,2]. Several studies have shown that there is a
correlation between the functional characterisation and the phylogenetic
classification of the ABC cassette [2,4]. More than 50 families have been
described based on a phylogenetic and functional classification [2,3,4] [E1].
Some ABC transporter families on which we developed a profile are listed
Active import transport system components:
Sulfate/thiosulfate import ATP-binding protein cysA (EC 18.104.22.168).
Phosphate import ATP-binding protein pstB (EC 22.214.171.124).
Molybdenum import ATP-binding protein modC (EC 126.96.36.199).
Ferric cations import ATP-binding protein fbpC (EC 188.8.131.52).
Maltose/maltodextrin import ATP-binding protein malK (EC 184.108.40.206).
Cobalt import ATP-binding protein cbiO.
Nickel import ATP-binding protein nikD/nikE (EC 220.127.116.11).
Phosphonates import ATP-binding protein phnC (EC 18.104.22.168).
Taurine import ATP-binding protein tauB (EC 22.214.171.124).
Ribose import ATP-binding protein rbsA (EC 126.96.36.199).
Galactose/methyl galactoside import ATP-binding protein mglA (EC 188.8.131.52).
Hemin import ATP-binding protein hmuV.
Methionine import ATP-binding protein metN.
Arabinose import ATP-binding protein araG (EC 184.108.40.206).
Xylose import ATP-binding protein xylG (EC 220.127.116.11).
Thiamine import ATP-binding protein thiQ.
Aliphatic sulfonate import ATP-binding protein ssuB.
Zinc import ATP-binding protein znuC.
Spermidine/putrescine import ATP-binding protein potA (EC 18.104.22.168).
sn-glycerol-3-phosphate import ATP-binding protein ugpC (EC 22.214.171.124).
Active export transport system components:
Lipid A export ATP-binding/permease protein msbA.
Nod factor export ATP-binding protein I.
Cytochrome c biogenesis ATP-binding export protein ccmA (EC 126.96.36.199).
Lipoprotein releasing system ATP-binding protein lolD.
Teichoic acids export ATP-binding protein tagH (EC 188.8.131.52).
Macrolide export ATP-binding/permease protein macB.
β-(1-->2)glucan export ATP-binding/permease protein ndvA (EC 184.108.40.206).
Each family profile was built on a discriminating region either in the ABC
cassette or in the C-terminal region.
June 2009 / Text revised.
PROSITE methods (with tools and information) covered by this documentation:
Holland I.B., Cole S.P.C., Kuchler K., Higgins C.F.
(In) ABC proteins from bacteria to man, Academic Press, San Diego, (2003).
Saurin W., Hofnung M., Dassa E.
Getting in or out: early segregation between importers and exporters in the evolution of ATP-binding cassette (ABC) transporters.
PROSITE is copyright. It is produced by the SIB Swiss Institute
Bioinformatics. There are no restrictions on its use by non-profit
institutions as long as its content is in no way modified. Usage by and
for commercial entities requires a license agreement. For information
about the licensing scheme send an email to
or see: prosite_license.html.