![]() |
|
PROSITE documentation PDOC51237 |
ABC transporters belong to the ATP-Binding Cassette (ABC) superfamily which use the hydrolysis of ATP to energize diverse biological systems. It forms one of the largest of all protein families with a diversity of physiological functions (see <PDOC00185>) [1,2]. Several studies have shown that there is a correlation between the functional characterisation and the phylogenetic classification of the ABC cassette [2,4]. More than 50 families have been described based on a phylogenetic and functional classification [2,3,4] [E1].
Some ABC transporter families on which we developed a profile are listed below.
Active import transport system components:
Active export transport system components:
Each family profile was built on a discriminating region either in the ABC cassette or in the C-terminal region.
Last update:June 2009 / Text revised.
-------------------------------------------------------------------------------
PROSITE methods (with tools and information) covered by this documentation:
1 | Authors | Holland I.B. Cole S.P.C. Kuchler K. Higgins C.F. |
Source | (In) ABC proteins from bacteria to man, Academic Press, San Diego, (2003). |
2 | Authors | Saurin W. Hofnung M. Dassa E. |
Title | Getting in or out: early segregation between importers and exporters in the evolution of ATP-binding cassette (ABC) transporters. | |
Source | J. Mol. Evol. 48:22-41(1999). | |
PubMed ID | 9873074 |
3 | Authors | Higgins C.F. |
Title | ABC transporters: physiology, structure and mechanism -- an overview. | |
Source | Res. Microbiol. 152:205-210(2001). | |
PubMed ID | 11421269 |
4 | Authors | Dassa E. Bouige P. |
Title | The ABC of ABCS: a phylogenetic and functional classification of ABC systems in living organisms. | |
Source | Res. Microbiol. 152:211-229(2001). | |
PubMed ID | 11421270 |
E1 | Source | http://www.tcdb.org/tcdb/index.php?tc=3.A.1 |