PROSITE documentation PDOC51237ABC transporter family profiles
ABC transporters belong to the ATP-Binding Cassette (ABC) superfamily which use the hydrolysis of ATP to energize diverse biological systems. It forms one of the largest of all protein families with a diversity of physiological functions (see <PDOC00185>) [1,2]. Several studies have shown that there is a correlation between the functional characterisation and the phylogenetic classification of the ABC cassette [2,4]. More than 50 families have been described based on a phylogenetic and functional classification [2,3,4] [E1].
Some ABC transporter families on which we developed a profile are listed below.
Active import transport system components:
- Sulfate/thiosulfate import ATP-binding protein cysA (EC 3.6.3.25).
- Phosphate import ATP-binding protein pstB (EC 3.6.3.27).
- Molybdenum import ATP-binding protein modC (EC 3.6.3.29).
- Ferric cations import ATP-binding protein fbpC (EC 3.6.3.30).
- Maltose/maltodextrin import ATP-binding protein malK (EC 3.6.3.19).
- Cobalt import ATP-binding protein cbiO.
- Nickel import ATP-binding protein nikD/nikE (EC 3.6.3.24).
- Phosphonates import ATP-binding protein phnC (EC 3.6.3.28).
- Taurine import ATP-binding protein tauB (EC 3.6.3.36).
- Ribose import ATP-binding protein rbsA (EC 3.6.3.17).
- Galactose/methyl galactoside import ATP-binding protein mglA (EC 3.6.3.17).
- Hemin import ATP-binding protein hmuV.
- Methionine import ATP-binding protein metN.
- Arabinose import ATP-binding protein araG (EC 3.6.3.17).
- Xylose import ATP-binding protein xylG (EC 3.6.3.17).
- Thiamine import ATP-binding protein thiQ.
- Aliphatic sulfonate import ATP-binding protein ssuB.
- Zinc import ATP-binding protein znuC.
- Spermidine/putrescine import ATP-binding protein potA (EC 3.6.3.31).
- sn-glycerol-3-phosphate import ATP-binding protein ugpC (EC 3.6.3.20).
Active export transport system components:
- Lipid A export ATP-binding/permease protein msbA.
- Nod factor export ATP-binding protein I.
- Cytochrome c biogenesis ATP-binding export protein ccmA (EC 3.6.3.41).
- Lipoprotein releasing system ATP-binding protein lolD.
- Teichoic acids export ATP-binding protein tagH (EC 3.6.3.40).
- Macrolide export ATP-binding/permease protein macB.
- β-(1-->2)glucan export ATP-binding/permease protein ndvA (EC 3.6.3.42).
Each family profile was built on a discriminating region either in the ABC cassette or in the C-terminal region.
Last update:June 2009 / Text revised.
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PROSITE methods (with tools and information) covered by this documentation:
| 1 | Authors | Holland I.B. Cole S.P.C. Kuchler K. Higgins C.F. |
| Source | (In) ABC proteins from bacteria to man, Academic Press, San Diego, (2003). |
| 2 | Authors | Saurin W. Hofnung M. Dassa E. |
| Title | Getting in or out: early segregation between importers and exporters in the evolution of ATP-binding cassette (ABC) transporters. | |
| Source | J. Mol. Evol. 48:22-41(1999). | |
| PubMed ID | 9873074 |
| 3 | Authors | Higgins C.F. |
| Title | ABC transporters: physiology, structure and mechanism -- an overview. | |
| Source | Res. Microbiol. 152:205-210(2001). | |
| PubMed ID | 11421269 |
| 4 | Authors | Dassa E. Bouige P. |
| Title | The ABC of ABCS: a phylogenetic and functional classification of ABC systems in living organisms. | |
| Source | Res. Microbiol. 152:211-229(2001). | |
| PubMed ID | 11421270 |
| E1 | Source | http://www.tcdb.org/tcdb/index.php?tc=3.A.1 |
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