PROSITE documentation PDOC51329 [for PROSITE entry PS51329]

C-CAP/cofactor C-like domain profile





Description

The C-CAP/cofactor C-like domain is present in several cytoskeleton-related proteins, which also contain a number of additional domains [1,2,3,4]:

  • Eukaryotic cyclase-associated protein (CAP or SRV2) (see <PDOC00835>), a modular actin monomer binding that directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity.
  • Vertebrate retinitis pigmentosa 2 (XRP2). In human, the protein responsible for X-linked forms of retinitis pigmentosa, a disease characterized by severe retinal degeneration.
  • Eukaryotic tubulin-specific chaperone cofactor C (TBCC), a GTPase- activating component of the tubulin-folding supercomplex, which directs the assembly of the α- and β-tubulin heterodimer.

The cyclase-associated protein C-CAP/cofactor C-like domain binds G-actin and is responsible for oligomerization of the entire CAP molecule [1], whereas the XRP2 C-CAP/cofactor C-like domain is required for binding of ADP ribosylation factor-like protein 3 (Arl3) [2].

The central core of the C-CAP/cofactor C-like domain is composed of six coils of right-handed parallel β-helix, termed coils 1-6, which form an elliptical barrel with a tightly packed interior. Each β-helical coil is composed of three relatively short β-strands, designated a-c, separated by sharp turns. Flanking the central β-helical core is an N-terminal β-strand, β0, that packs antiparallel to the core, and strand β7 packs antiparallel to the core near the C-terminal end of the parallel β-helix (see <PDB:1K4Z>) [1,2].

The profile we developed covers the C-CAP/cofactor C-like domain.

Last update:

August 2007 / First entry.

Technical section

PROSITE method (with tools and information) covered by this documentation:

C_CAP_COFACTOR_C, PS51329; C-CAP/cofactor C-like domain profile  (MATRIX)


References

1AuthorsDodatko T., Fedorov A.A., Grynberg M., Patskovsky Y., Rozwarski D.A., Jaroszewski L., Aronoff-Spencer E., Kondraskina E., Irving T., Godzik A., Almo S.C.
TitleCrystal structure of the actin binding domain of the cyclase-associated protein.
SourceBiochemistry 43:10628-10641(2004).
PubMed ID15311924
DOI10.1021/bi049071r

2AuthorsKuehnel K., Veltel S., Schlichting I., Wittinghofer A.
TitleCrystal structure of the human retinitis pigmentosa 2 protein and its interaction with Arl3.
SourceStructure 14:367-378(2006).
PubMed ID16472755
DOI10.1016/j.str.2005.11.008

3AuthorsStephan A., Vaughan S., Shaw M.K., Gull K., McKean P.G.
TitleAn Essential Quality Control Mechanism at the Eukaryotic Basal Body Prior to Intraflagellar Transport.
SourceTraffic 0:0-0(2007).
PubMed ID17645436
DOI10.1111/j.1600-0854.2007.00611.x

4AuthorsGrynberg M., Jaroszewski L., Godzik A.
TitleDomain analysis of the tubulin cofactor system: a model for tubulin folding and dimerization.
SourceBMC Bioinformatics 4:46-46(2003).
PubMed ID14536023
DOI10.1186/1471-2105-4-46



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