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PROSITE documentation PDOC51335 [for PROSITE entry PS51335]

ELMO domain profile





Description

Regulatory GTPases in the Ras superfamily employ a cycle of alternating GTP binding and hydrolysis, controlled by guanine nucleotide exchange factors and GTPase-activating proteins (GAPs), as essential features of their actions in cells. Within the Ras superfamily, the Arf family is composed of 30 members, including 22 Arf-like (Arl) proteins. The ELMO (for EnguLfment and cell MOtility) domain has been proposed to be a GAP domain for ARL2 and other members of the Arf family [1].

The profile we developed covers the entire ELMO domain.

Last update:

October 2007 / First entry.

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Technical section

PROSITE method (with tools and information) covered by this documentation:

ELMO, PS51335; ELMO domain profile  (MATRIX)


Reference

1AuthorsBowzard J.B. Cheng D. Peng J. Kahn R.A.
TitleELMOD2 is an Arl2 GTPase-activating protein that also acts on Arfs.
SourceJ. Biol. Chem. 282:17568-17580(2007).
PubMed ID17452337
DOI10.1074/jbc.M701347200



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