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PROSITE documentation PDOC51398 [for PROSITE entry PS51398] |
The PAW domain (present in PNGases and other worm proteins) is found as a single copy at the C-terminus of metazoan peptide:N-glycanase (PNGase) and in multiple copies in hypothetical Caenorhabditis elegans proteins peptide:N-glycanases (PNGases) [1]. The C-terminal PAW domain of PNGase binds to the mannose moieties of N-linked oligosaccharide chains [2].
The PAW domain is a slightly elongated molecule and displays a β-sandwich architecture, which is composed of two layers, containing nine and eight antiparallel β-strands, respectively, and three additional short helices (see <PDB:2G9G>) [2].
Some proteins known to contain a PAW domain are listed below:
The profile we developed covers the entire PAW domain.
Last update:July 2008 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
1 | Authors | Doerks T. Copley R.R. Schultz J. Ponting C.P. Bork P. |
Title | Systematic identification of novel protein domain families associated with nuclear functions. | |
Source | Genome Res. 12:47-56(2002). | |
PubMed ID | 11779830 | |
DOI | 10.1101/ |
2 | Authors | Zhou X. Zhao G. Truglio J.J. Wang L. Li G. Lennarz W.J. Schindelin H. |
Title | Structural and biochemical studies of the C-terminal domain of mouse peptide-N-glycanase identify it as a mannose-binding module. | |
Source | Proc. Natl. Acad. Sci. U.S.A. 103:17214-17219(2006). | |
PubMed ID | 17088551 | |
DOI | 10.1073/pnas.0602954103 |