|PROSITE documentation PDOC51398 [for PROSITE entry PS51398]|
The PAW domain (present in PNGases and other worm proteins) is found as a single copy at the C-terminus of metazoan peptide:N-glycanase (PNGase) and in multiple copies in hypothetical Caenorhabditis elegans proteins peptide:N-glycanases (PNGases) . The C-terminal PAW domain of PNGase binds to the mannose moieties of N-linked oligosaccharide chains .
The PAW domain is a slightly elongated molecule and displays a β-sandwich architecture, which is composed of two layers, containing nine and eight antiparallel β-strands, respectively, and three additional short helices (see <PDB:2G9G>) .
Some proteins known to contain a PAW domain are listed below:
The profile we developed covers the entire PAW domain.Last update:
July 2008 / First entry.
PROSITE method (with tools and information) covered by this documentation:
|1||Authors||Doerks T. Copley R.R. Schultz J. Ponting C.P. Bork P.|
|Title||Systematic identification of novel protein domain families associated with nuclear functions.|
|Source||Genome Res. 12:47-56(2002).|
|2||Authors||Zhou X. Zhao G. Truglio J.J. Wang L. Li G. Lennarz W.J. Schindelin H.|
|Title||Structural and biochemical studies of the C-terminal domain of mouse peptide-N-glycanase identify it as a mannose-binding module.|
|Source||Proc. Natl. Acad. Sci. U.S.A. 103:17214-17219(2006).|