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PROSITE documentation PDOC51398 [for PROSITE entry PS51398]

PAW domain profile





Description

The PAW domain (present in PNGases and other worm proteins) is found as a single copy at the C-terminus of metazoan peptide:N-glycanase (PNGase) and in multiple copies in hypothetical Caenorhabditis elegans proteins peptide:N-glycanases (PNGases) [1]. The C-terminal PAW domain of PNGase binds to the mannose moieties of N-linked oligosaccharide chains [2].

The PAW domain is a slightly elongated molecule and displays a β-sandwich architecture, which is composed of two layers, containing nine and eight antiparallel β-strands, respectively, and three additional short helices (see <PDB:2G9G>) [2].

Some proteins known to contain a PAW domain are listed below:

  • Animal peptide:N-glycanase (PNGase) (EC 3.5.1.52), catalyzes the deglycosylation of several misfolded N-linked glycoproteins by cleaving the bulky glycan chain before the proteins are degraded by the proteasome.
  • Caenorhabditis elegans putative uncharacterized protein C17B7.5.

The profile we developed covers the entire PAW domain.

Last update:

July 2008 / First entry.

Technical section

PROSITE method (with tools and information) covered by this documentation:

PAW, PS51398; PAW domain profile  (MATRIX)


References

1AuthorsDoerks T. Copley R.R. Schultz J. Ponting C.P. Bork P.
TitleSystematic identification of novel protein domain families associated with nuclear functions.
SourceGenome Res. 12:47-56(2002).
PubMed ID11779830
DOI10.1101/

2AuthorsZhou X. Zhao G. Truglio J.J. Wang L. Li G. Lennarz W.J. Schindelin H.
TitleStructural and biochemical studies of the C-terminal domain of mouse peptide-N-glycanase identify it as a mannose-binding module.
SourceProc. Natl. Acad. Sci. U.S.A. 103:17214-17219(2006).
PubMed ID17088551
DOI10.1073/pnas.0602954103



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