The Gas2-related (GAR) domain was named after Gas2 (growth arrest specific 2)
and is common in plakin family members and Gas2 family members. The GAR domain
comprises ~57 amino acids and has been shown to bind to microtubules [1,2].
Some proteins known to contain a GAR domain are listed below:
Mammalian Gas2, a cytoskeletal protein that is highly upregulated in
Mammalian Gas2-related on chromosome 22 (GAR22).
Mammalian MACF, a protein that can associate with both actin microfilaments
Mammalian bullous pemphigoid 1 (BPAG1).
Drosophila Kakapo/Shortstop, a microtubule and microfilament organizer
important for axonal outgrowth, local dendritic extension and maintaining
the integrity of cell layers.
Drosophila protein CG3973, the homologue of Gas2.
Caenorhabditis elegans ZK1151, the orthologue of Kakapo/Short stop.
The profile we developed covers the entire GAR domain.
March 2010 / First entry.
PROSITE method (with tools and information) covered by this documentation:
Sun D. Leung C.L. Liem R.K.H.
Characterization of the microtubule binding domain of microtubule actin crosslinking factor (MACF): identification of a novel group of microtubule associated proteins.
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