The Gas2-related (GAR) domain was named after Gas2 (growth arrest specific 2) and is common in plakin family members and Gas2 family members. The GAR domain comprises ~57 amino acids and has been shown to bind to microtubules [1,2].

Some proteins known to contain a GAR domain are listed below:

• Mammalian Gas2, a cytoskeletal protein that is highly upregulated in growth-arrested fibroblasts.
• Mammalian Gas2-related on chromosome 22 (GAR22).
• Mammalian MACF, a protein that can associate with both actin microfilaments and microtubules.
• Mammalian bullous pemphigoid 1 (BPAG1).
• Drosophila Kakapo/Shortstop, a microtubule and microfilament organizer important for axonal outgrowth, local dendritic extension and maintaining the integrity of cell layers.
• Drosophila protein CG3973, the homologue of Gas2.
• Caenorhabditis elegans ZK1151, the orthologue of Kakapo/Short stop.

The profile we developed covers the entire GAR domain.