PROSITE entry PS51460

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General information about the entry

PURL [info]	https://purl.expasy.org/prosite/signature/PS51460
Entry name [info]	GAR
Accession [info]	PS51460
Entry type [info]	MATRIX
Date [info]	01-MAR-2010 CREATED; 26-FEB-2020 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC51460
Associated ProRule [info]	PRU00792

Name and characterization of the entry

Description [info]

GAR domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=74;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=69;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.7160497; R2=0.0086696; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=9880.3740234; R2=2.7806418; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=668; H_SCORE=11738; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=437; H_SCORE=11096; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-39; D=-100; I=-100; B1=-1000; E1=-1000; MI=-255; MD=-255; IM=-255; DM=-255;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-255; BD=-255;
/M: SY='T';  M=  16,  21, -15, -46, -88,   9, -36, -25, -35, -38,   5,  35, -53, -38, -30,  25,  49, -57,-100, -85;
/M: SY='P';  M= -53, -98,  48, -17, -89, -43,  35, -38,  12, -92, -84, -71,  77, -43, -32, -41,  19, -89, -95,  17;
/M: SY='G';  M=   4, -89, -34, -13, -51,  32,   7, -45,   4, -18, -51,  20, -38,   1,  -6,  27,  18, -82, -96, -83;
/M: SY='D';  M= -27, -37,  51,  24, -17, -29,  25, -84,   7,  10, -78, -12,  40, -43, -14, -30, -76, -47, -98, -80;
/M: SY='T';  M= -18, -88,  10, -34, -55, -83, -79, -58,  46, -12,   0, -19,  19, -30, -25,  23,  50, -79, -97, -82;
/M: SY='L';  M= -63, -89, -93, -35, -16, -67, -85,  32,  -9,  64, -54, -41, -39, -18, -31, -51, -39, -15, -89, -36;
/M: SY='D';  M= -19, -91,  74,   3, -94, -18,  23, -46, -72, -89, -31, -21, -17, -13, -36, -11,  49, -46,-107, -84;
/M: SY='D';  M=  -6, -95,  59,  21, -16, -84,  19, -36, -74, -30, -80, -30,  48,  28, -80,  -6, -48, -11,-100, -81;
/M: SY='A';  M=  61, -86, -24,  43, -90, -78, -14, -49, -73, -25,   3, -32, -23,  11, -79, -12,   0, -42, -96, -85;
/M: SY='V';  M= -23, -89, -96, -91,  24, -48, -92,  33, -58,   2, -62, -48,  21, -90, -34, -84, -74,  64, -90, -11;
/M: SY='R';  M=  30, -90,  24, -32, -91,  -6,  18, -46,  20, -68, -81, -12, -85,  -4,  37,  21, -14, -56, -30, -27;
/M: SY='R';  M= -40, -96,   6,  26, -90, -87,  39, -92,  32, -31,  -5,  18,  13, -28,  60, -27, -76, -90, -96, -32;
/M: SY='I';  M= -40, -37, -85, -46,   4, -15, -81,  35,  17,  13, -66, -31, -51,  32,  16,  -2, -54,  -3, -87,  -4;
/M: SY='V';  M=  -9,   0, -33, -27, -36, -68, -30,  10, -19,  15,  12, -44, -32, -26,  25,  -8, -55,  45, -96, -78;
/M: SY='N';  M=  13,   3,   4,   7, -44, -19,  13, -90, -17, -58, -23,  56, -86, -32,  26,   8,  11, -85,   9, -37;
/I:         I=-16; MD=-40;
/M: SY='S';  M= -27,-104, -21,  18,-105, -42, -31, -32,  -5, -54, -35, -13,  13, -26,   8,  35, -59, -96,-110, -97; D=-16;
/I:         I=-16; MI=0; MD=-40; IM=0; DM=-40;
/M: SY='H';  M= -59, -95,   9, -16, -87, -23,  49, -45,  20, -23, -78, -12,  27,  12,  47, -12,  11, -86, -95,  -9;
/M: SY='C';  M=  -2, 108,   0, -79, -85, -87, -40, -16,  -8, -24, -76, -52, -52,  20, -25,   4,  -5,   4,-103, -86;
/M: SY='T';  M=  -9, -37,  17, -69, -90, -81,  17, -44,   3, -49, -80,  41,  29,  -3,  30,   5,  42, -52,-100, -49;
/M: SY='C';  M= -33, 109, -78,  15, -91,  -8,   8, -45,   7, -86,   9,   4,  18, -18, -80,   8, -74, -59,-103, -88;
/M: SY='P';  M=  -2,  31,  20,  17, -91, -86, -16, -28,  19, -33, -33, -75,  64,   8,   5, -44, -21, -19, -98, -86;
/M: SY='N';  M= -34, -88,  13, -71, -87,  -9,   6, -83,   7, -10, -20,  57,  12,  12, -40,  27,  24, -58, -99, -33;
/I:         I=-24; MI=0; MD=-61; IM=0; DM=-61;
/M: SY='K';  M= -18, -28, -76,  -2, -89, -15, -79,   9,  32, -44, -76, -28,  30,  29,  26,  18,   5, -25, -94, -83;
/M: SY='F';  M= -80, -90,  15, -24,  67, -33,  -8, -26, -81, -12, -12, -23,  24, -43, -20, -16, -24,  20, -78,  20;
/M: SY='Q';  M= -19,  43, -16, -34, -89, -53, -34, -79,  37, -17, -21,  -9,  29,  51,  15,   2, -73,   4, -96, -83;
/M: SY='M';  M= -78, -15,  10,   7,   8, -56, -84,  25, -81,  21,  43, -83, -33, -80,  -7, -81,  -4,  41, -92, -42;
/M: SY='Q';  M= -28, -94, -13,  36,   5, -42, -14,  19,  -4, -23, -51, -78, -87,  44,  -7, -53, -62,   3,  35,  43;
/M: SY='R';  M= -81, -97, -73,  -6, -87, -89,  56, -94,  50, -89, -78, -34, -86,  30,  78, -41, -78, -54, -90,  12;
/M: SY='I';  M= -58, -89,  10,  15, -71, -95, -82,  38, -33,  34,  27, -24, -89,  29, -81, -81, -74,  34, -93, -28;
/M: SY='H';  M=   1, -90,  11, -37, -82,  30,  61, -38,   7, -88, -80, -66, -23,   7, -74,  48, -70, -85, -88,  37;
/M: SY='E';  M= -77, -96,  25,  70, -93, -34,  55, -93, -11, -26, -81, -68,   4,  25,  19, -21, -19, -90, -98, -80;
/M: SY='G';  M= -35, -91, -35, -87, -91,  89, -83, -93, -44,   0, -82,  18, -55, -81, -89, -39, -80, -90, -91, -89;
/M: SY='K';  M= -75, -92, -33, -66, -89,   5,  13, -87,  62, -31, -78, -59, -84,  24,  55,   7,  -6, -30, -92, -45;
/M: SY='Y';  M= -84, -43, -26, -43, -20, -91,  -8, -78,  16, -75, -70, -80, -94,  -5,  11, -35, -79, -81, -54, 117;
/M: SY='R';  M=   0,   9, -78, -72, -37, -83, -75, -50,   4, -12, -76,  21,   7,  -3,  73,  12, -37, -40,  35, -78;
/I:         I=-18; MI=0; MD=-45; IM=0; DM=-45;
/M: SY='F';  M=  -4, -87, -93, -91,  68, -26, -87,  43, -88, -22,  -9, -17, -24, -89, -90, -19, -25,  32, -78,   0;
/M: SY='G';  M= -24, -93, -80, -49,  -9,  88, -85,-100,  -5, -97, -88, -69,  27, -80, -86, -29, -81, -95, -88, -88;
/M: SY='D';  M= -12, -90,  64,  45, -92,   5,   9, -88, -31, -21, -83,  14, -81, -67, -76,   2,  20, -49,-102, -84;
/M: SY='K';  M=  -7, -88, -38,  -5, -92, -26, -76, -88,  69, -66, -81, -66, -35,  -7,  16,  43,   9, -40, -93, -83;
/I:         I=-24; MD=-61;
/M: SY='Q';  M= -53,-108,  13, -82,-103, -17,  11, -97,  -1,   2, -89, -47,  34,  36, -88,   2, -47, -98,-110, -96; D=-24;
/I:         I=-24; MI=0; MD=-61; IM=0; DM=-61;
/M: SY='K';  M= -78,-106, -96, -89,  17,-106, -97,  27,  44, -68, -85, -32,   3, -18, -27, -89,  13, -28,-102, -86; D=-24;
/I:         I=-24; DM=-61;
/M: SY='M';  M= -77, -11, -88, -81, -43, -29, -83,  35,  36,  28,  40, -39, -34, -43,   3, -15, -73,  26, -91, -75;
/M: SY='R';  M= -79,  45, -93, -85, -68, -99, -83,  41, -73,  30, -59, -87, -95, -19,  53, -84, -76,  36, -89,  11;
/M: SY='F';  M= -83, -87, -92, -90,  92, -43,   6, -26, -85,  14,  19, -23, -94, -88, -18,  -5,  12, -68, -70, -14;
/M: SY='V';  M= -39,  33, -99, -94, -68,-100, -99,  57, -92,   4, -56, -93, -94, -92, -94, -84, -45,  76, -98, -77;
/M: SY='R';  M= -80, -97, -79, -69, -90,   8, -71, -93,  18, -28, -78, -72, -90, -12, 102, -76, -81, -61, -91, -80;
/M: SY='I';  M= -40,  37, -85,  15, -30, -47, -82,  51, -75,   6,  44, -82, -88,  -6,  19, -47,  -4,  15, -90, -14;
/M: SY='L';  M= -40, -85,   0,  11, -29, -92, -81, -54, -26,  61,  -7, -29, -90, -77, -82, -10,  -5,  30, -92, -73;
/M: SY='R';  M= -60, -96, -76, -38, -95,  54,  45,-101,  -3, -95, -83,  -6, -87,  20,  72, -71, -30, -96, -95, -82;
/M: SY='E';  M= -70, -91, -45,  54, -95,  28, -19, -96, -17, -50, -86,  31, -81,  -1,   4,  52, -56, -91, -97, -86;
/I:         I=-14; MI=0; MD=-35; IM=0; DM=-35;
/M: SY='H';  M= -25, -92, -74, -70, -89, -86,  95, -93,  31, -87, -20,  -1, -85, -64,  61, -49,  39, -88,-102, -72;
/M: SY='V';  M= -72, -17,-100, -94, -70,-101, -99,  11, -92,   0,  12, -95, -96, -93, -93, -84, -33,  90,-102, -77;
/M: SY='M';  M= -78, -86,-100, -90, -12, -93, -73, -28, -84,  -9, 138, -88, -89, -77, -82, -88, -76,  -9, -89, -66;
/M: SY='V';  M= -41,  29, -99, -94, -71,-100,-102,   3, -91, -57, -60, -94, -96, -94, -93, -82, -68,  97,-104, -79;
/M: SY='R';  M= -83,-100, -80, -68, -93, -93, -69, -99, -10, -92, -81, -73,  -9, -57, 112, -78, -82, -93, -92, -80;
/M: SY='V';  M= -70, -84, -99, -93, -70, -99, -99,  30, -91, -55,  13, -93, -94, -91, -92, -25, -68,  93,-102, -77;
/M: SY='G';  M= -66, -93, -79, -22,-100, 100, -87,-107, -85,-102, -92, -67, -84, -82, -92, -66, -84,-100, -90, -94;
/M: SY='G';  M= -66, -93, -79, -92, -99, 100, -86,-107, -85,-103, -92,  -6, -85, -83, -93, -66, -84,-100, -91, -94;
/M: SY='G';  M= -66, -93, -14, -90,-100, 100, -87,-107, -86,-103, -92, -66, -85, -83, -93, -66, -84,-101, -91, -94;
/M: SY='W';  M= -92,-114,-117, -97,  10, -91,-112, -87, -89, -84, -88,-110, -96, -89, -92, -98,-102,-101, 173,   5;
/M: SY='M';  M=  38, -88,  50,  21, -86, -82, -77,   5, -74, -22,  51, -72, -84,  35, -79, -25, -34,  -8, -97, -81;
/M: SY='T';  M=  14, -86,  70,  -9, -92, -30, -79, -84, -74, -88, -84, -62, -20, -74, -81,  -4,  72, -34,-105, -85;
/M: SY='L';  M= -82, -84, -99, -92,  -8,-101, -84,  16, -93,  87, -44, -97, -98, -86, -90, -92, -77, -52, -84, -66;
/M: SY='D';  M=  13, -90,  59,  54, -97,  29, -72, -96,  12, -93, -87, -25, -78,  -5, -38,  13, -71, -89, -97, -86;
/M: SY='E';  M= -76, -95, -18,  92, -94, -12,  79, -98, -34, -89, -82, -32, -75,  -9,   1, -71, -77, -64, -98, -77;
/M: SY='Y';  M= -87, -91, -92, -92,  91, -94, -65, -68, -86, -62, -66, -88, -98, -86, -83, -34, -80, -73,  27, 106;
/M: SY='L';  M= -81, -84, -99, -92, -22,-101, -84,  10, -93,  88, -44, -98, -98, -86, -90, -91, -77, -34, -85, -67;
/M: SY='R';  M= -39, -89,  37, -25, -81, -31,   2, -69,   3,  17, -36, -70, -86,  38,  47, -12, -14,  24, -95, -76;
/M: SY='K';  M= -38, -90,   5,  42, -35, -86, -73, -79,  72,  -4, -74, -19, -80,   8,   6, -38, -36,  -4, -91, -78;
/M: SY='H';  M= -83, -92, -69, -75, -32, -83,  99, -84, -29, -34, -70,  62, -90, -66,  16, -73, -76, -86, -74,  87;
/M: SY='D';  M=  31, -88,  88, -16,   0, -78,  -2, -81, -72, -21, -15,  -4, -83,   8, -78, -68, -23, -18,-100, -77;
/M: SY='P';  M= -12, -93, -78,  -8, -87, -81,  -4,   6,  -6, -27,  18, -45,  94, -73, -80,  31, -28, -47, -93, -84;
/M: SY='C';  M= -38, 117, -20, -10, -85, -11,  88, -86, -12, -52,  -5, -71, -91, -13, -79, -74, -37, -19,-107, -77;
/M: SY='H';  M= -80, -94, -34, -24, -85, -87,  92, -89,  -1, -33,   7,  -5, -86, -28,  85, -14, -77, -52, -97, -69;
/I:         E1=0; IE=-255; DE=-255;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.

Total number of hits	19 in 19 different sequences
Number of true positive hits	19 in 19 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	DOMAIN
Feature description [info]	GAR
Version [info]	5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

19 sequences

DYST_HUMAN  (Q03001), DYST_MOUSE  (Q91ZU6), G2L2L_XENLA (A0A1L8HFX9),

G2L2S_XENLA (A0A1L8H8C0), GA2L1_HUMAN (Q99501), GA2L1_MOUSE (Q8JZP9), 
GA2L2_HUMAN (Q8NHY3), GA2L2_MOUSE (Q5SSG4), GA2L2_RAT   (D3ZUE1), 
GA2L3_HUMAN (Q86XJ1), GA2L3_MOUSE (Q3UWW6), GA2PE_DROME (Q9W3Y4), 
GAS2_HUMAN  (O43903), GAS2_MOUSE  (P11862), K0754_HUMAN (O94854), 
K0754_MOUSE (Q69ZZ9), MACF1_HUMAN (Q9UPN3), MACF1_MOUSE (Q9QXZ0), 
MACF1_RAT   (D3ZHV2)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

3 PDB

1V5R; 5VE9; 5X57