We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC51460GAR domain profile
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PURL: https://purl.expasy.org/prosite/documentation/PDOC51460
Description
The Gas2-related (GAR) domain was named after Gas2 (growth arrest specific 2) and is common in plakin family members and Gas2 family members. The GAR domain comprises ~57 amino acids and has been shown to bind to microtubules [1,2].
Some proteins known to contain a GAR domain are listed below:
- Mammalian Gas2, a cytoskeletal protein that is highly upregulated in growth-arrested fibroblasts.
- Mammalian Gas2-related on chromosome 22 (GAR22).
- Mammalian MACF, a protein that can associate with both actin microfilaments and microtubules.
- Mammalian bullous pemphigoid 1 (BPAG1).
- Drosophila Kakapo/Shortstop, a microtubule and microfilament organizer important for axonal outgrowth, local dendritic extension and maintaining the integrity of cell layers.
- Drosophila protein CG3973, the homologue of Gas2.
- Caenorhabditis elegans ZK1151, the orthologue of Kakapo/Short stop.
The profile we developed covers the entire GAR domain.
Last update:March 2010 / First entry.
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Technical section
PROSITE method (with tools and information) covered by this documentation:
References
| 1 | Authors | Sun D. Leung C.L. Liem R.K.H. |
| Title | Characterization of the microtubule binding domain of microtubule actin crosslinking factor (MACF): identification of a novel group of microtubule associated proteins. | |
| Source | J. Cell Sci. 114:161-172(2001). | |
| PubMed ID | 11112700 |
| 2 | Authors | Leung C.L. Green K.J. Liem R.K.H. |
| Title | Plakins: a family of versatile cytolinker proteins. | |
| Source | Trends Cell Biol. 12:37-45(2002). | |
| PubMed ID | 11854008 |
Copyright
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