PROSITE documentation PDOC51460GAR domain profile
Description
The Gas2-related (GAR) domain was named after Gas2 (growth arrest specific 2) and is common in plakin family members and Gas2 family members. The GAR domain comprises ~57 amino acids and has been shown to bind to microtubules [1,2].
Some proteins known to contain a GAR domain are listed below:
- Mammalian Gas2, a cytoskeletal protein that is highly upregulated in growth-arrested fibroblasts.
- Mammalian Gas2-related on chromosome 22 (GAR22).
- Mammalian MACF, a protein that can associate with both actin microfilaments and microtubules.
- Mammalian bullous pemphigoid 1 (BPAG1).
- Drosophila Kakapo/Shortstop, a microtubule and microfilament organizer important for axonal outgrowth, local dendritic extension and maintaining the integrity of cell layers.
- Drosophila protein CG3973, the homologue of Gas2.
- Caenorhabditis elegans ZK1151, the orthologue of Kakapo/Short stop.
The profile we developed covers the entire GAR domain.
Last update:March 2010 / First entry.
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Technical section
PROSITE method (with tools and information) covered by this documentation:
References
| 1 | Authors | Sun D. Leung C.L. Liem R.K.H. |
| Title | Characterization of the microtubule binding domain of microtubule actin crosslinking factor (MACF): identification of a novel group of microtubule associated proteins. | |
| Source | J. Cell Sci. 114:161-172(2001). | |
| PubMed ID | 11112700 |
| 2 | Authors | Leung C.L. Green K.J. Liem R.K.H. |
| Title | Plakins: a family of versatile cytolinker proteins. | |
| Source | Trends Cell Biol. 12:37-45(2002). | |
| PubMed ID | 11854008 |
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