|PROSITE documentation PDOC51470 [for PROSITE entry PS51470]|
Integrins are cell adhesion receptors that transmit bidirectional signals across the plasma membrane and link the extracellular environment to the actin cytoskeleton . Integrins are formed from α and β subunits. The N-terminal region of α subunits contains seven 60 amino acids sequence repeats which fold into a β-propeller domain . Integrins bind ligands at the interface between the α subunit β-propeller domain and β subunit I domain . These domains associate over a large interface to form the integrin head. The seven FG-GAP repeat domain is also found in the enzyme phosphatidylinositol phospholipase D.
The crystal structure of the β-propeller FG-GAP domain of integrin α V shows that the domain consists of seven radially arranged "blades" each formed from a four-stranded antiparallel sheet (ABCD) (see <PDB:1JV2>) . The inner strand (strand A) of each blade lines the channel at the center of the propeller, and strand D of the next repeat forming the outer edge of the blade. The β-propeller is circularized by juxtaposition of the C7 and D1 strands. Several Ca2+-binding sites are found in hairpin loops connecting β strands.
The profile we developed covers strand B,C,D and A of the FG-GAP repeat.Last update:
December 2009 / First entry.
PROSITE method (with tools and information) covered by this documentation:
|Title||Folding of the N-terminal, ligand-binding region of integrin alpha-subunits into a beta-propeller domain.|
|Source||Proc. Natl. Acad. Sci. U.S.A. 94:65-72(1997).|
|2||Authors||Loftus J.C., Smith J.W., Ginsberg M.H.|
|Title||Integrin-mediated cell adhesion: the extracellular face.|
|Source||J. Biol. Chem. 269:25235-25238(1994).|
|3||Authors||Xiong J.P., Stehle T., Zhang R., Joachimiak A., Frech M., Goodman S.L., Arnaout M.A.|
|Title||Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand.|
|4||Authors||Xiong J.P., Stehle T., Diefenbach B., Zhang R., Dunker R., Scott D.L., Joachimiak A., Goodman S.L., Arnaout M.A.|
|Title||Crystal structure of the extracellular segment of integrin alpha Vbeta3.|