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PROSITE documentation PDOC51548 [for PROSITE entry PS51548]

Birnavirus VP4 protease domain profile





Description

Viruses of the Birnaviridae family [E1] infect animal species belonging to vertebrates, mollusks, insects and rotifers and are characterized by their bi-segmented double-stranded RNA genome (segments A and B). Segment A encodes two overlapping reading frames and the larger open reading frame encodes a polyprotein (NH2-pVP2-VP4-VP3-COOH). The polyprotein is processed through the proteolytic activity of VP4 to generate pVP2 and VP3. During virus assembly pVP2 is further processed by VP4 to generate the capsid protein VP2 and structural peptides. Evolutionarily, the VP4 protease of the Birnaviridae family belongs to clan SJ and family S50 [E2] [1,2,3].

The birnavirus VP4 protease domain displays a catalytic serine/lysine dyad in its active site. The birnavirus VP4 protease domain has an α/β fold (see <PDB:2PNL>) [2,3].

The profile we developed covers the entire birnavirus VP4 protease domain.

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Last update:

September 2011 / First entry.

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Technical section

PROSITE method (with tools and information) covered by this documentation:

?, PS51548;   (?)


Reference



PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

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