The following proteins of the tesmin/TSO1 family contain two cysteines-rich
repeats with the consensus C-X-C-X(4)-C-X(3)-Y-C-X-C-X(6)-C-X(3)-C-X-C-X(2)-C
separated by a region of variable length containing the short conserved
Animal tesmin or MTL5, originally identified by its specific expression in
testes, but subsequently it was also detected at specific stages of ovary
Animal tesmin-like (tesl) or LIN54.
Drosophila melanogaster tombola (tomb), a meiotic arrest protein which is
expressed specifically in testis.
Arabidopsis thaliana TSO1, 'tso' means 'ugly' in Chinese and refers to the
appearance of tso1 mutant flowers.
Arabidopsis thaliana TSO1-like 1 and 2 (SOL1 and SOL2).
Legume Cysteine-rich Polycomb-like Protein 1 (CPP1), a DNA-binding protein
acting as a negative regulator of the leghemoglobin gene.
This domain has been named the CRC domain (C1-RNPXAFXPK-C2). It binds zinc and
is able to bind DNA [1,2,3,4,5].
The CRC domain shows some similarity to the CXC domain found in the E(z)-type
of Polycomb group proteins (see <PDOC51633>) . However, a clear distinction
can be made since the CXC domain lacks the RNPXAFXPK motif.
The profile we developed covers the entire CRC domain.
January 2012 / First entry.
PROSITE method (with tools and information) covered by this documentation:
Song J.-Y. Leung T. Ehler L.K. Wang C. Liu Z.
Regulation of meristem organization and cell division by TSO1, an Arabidopsis gene with cysteine-rich repeats.
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