MORF4 (mortality factor on chromosome 4), MRG15 (MORF4-related gene on
chromosome 15) and MRGX (MORF4-related gene on chromosome X) are members of
the MRG protein family that were first identified as transcription factors
involved in cellular senescence. All expressed members of the MRG family are
localized to the nucleus and have predicted motifs that indicate they function
as chromatin remodeling complex components. MORF4, MRG15 and MRGX share a
common C-terminal part but a different N-terminal part. The C-terminal
similarity of all MRG family members (MORF4, MRG15 and MRGX homologs) defines
a new conserved protein domain. The ~170 amino acid MRG domain binds a
plethora of transcriptional regulators and chromatin-remodeling factors,
including the histone deacetylase transriptional corepressor mSin3A and the
nuclear protein PAM14 (protein-associated MRG, 14kDa) [1,2].
The MRG domain consists of three conserved blocks. It is predominantly
hydrophobic, and consists of mainly α-helices that are arranged in a three
layer sandwich topology (see <PDB:2F5J>). The hydrophobic core is stabilized
by interactions among a number of conserved hydrophobic residues. The
molecular surface is largely hydrophobic, but contains a few hydrophilic
The profile we developed covers the entire MRG domain.
February 2012 / First entry.
PROSITE method (with tools and information) covered by this documentation:
Bertram M.J. Berube N.G. Hang-Swanson X. Ran Q. Leung J.K. Bryce S. Spurgers K. Bick R.J. Baldini A. Ning Y. Clark L.J. Parkinson E.K. Barrett J.C. Smith J.R. Pereira-Smith O.M.
Identification of a gene that reverses the immortal phenotype of a subset of cells and is a member of a novel family of transcription factor-like genes.
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