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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00972


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00972
General rule information [?]

Accession PRU00972
Dates 05-MAR-2013 (Created)
27-JUN-2022 (Last updated, Version 8)
Data class Domain;
Predictors PROSITE; PS51640; MRG
Name MRG domain
Function The ~170 amino acid MRG domain binds a plethora of transcriptional regulators and chromatin-remodeling factors, including the histone deacetylase transriptional corepressor mSin3A and the nuclear protein PAM14 (protein-associated MRG, 14kDa).
Scope(s) Eukaryota
Example(s) Q9WVG9;

Propagated annotation [?]

Comments [?]

SUBCELLULAR LOCATIONNucleus.

Keywords [?]

Chromatin regulator
Transcription
Transcription regulation

Gene Ontology [?]

GO:0006325; Biological process:chromatin organization
GO:0006351; Biological process:DNA-templated transcription
GO:0006355; Biological process:regulation of DNA-templated transcription

Features [?]

From: PS51640
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="MRG #"

Additional information [?]

Size range 154-360 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]