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PROSITE documentation PDOC51664 [for PROSITE entry PS51664]

YcaO domain profile





Description

The YcaO domain is found in the following proteins:

  • Escherichia YcaO, involved in β-methylthiolation of ribosomal protein S12 [1].
  • Bacterial and archeal thiazole/oxazole-modified microcin (TOMM) D protein, which uses ATP to activate amide backbones during peptide cyclodehydrations [2].

The YcaO domain is likely to be involved in post-translational modification (PTM) of amino acid residues.

The profile we developed covers the entire YcaO domain.

Last update:

January 2013 / First entry.

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Technical section

PROSITE method (with tools and information) covered by this documentation:

YCAO, PS51664; YcaO domain profile  (MATRIX)


References

1AuthorsStrader M.B. Costantino N. Elkins C.A. Chen C.Y. Patel I. Makusky A.J. Choy J.S. Court D.L. Markey S.P. Kowalak J.A.
TitleA proteomic and transcriptomic approach reveals new insight into beta-methylthiolation of Escherichia coli ribosomal protein S12. Mol. Cell. Proteomics 10:M110.005199-M110.005199(2011).
PubMed ID21169565
DOI10.1074/mcp.M110.005199

2AuthorsDunbar K.L. Melby J.O. Mitchell D.A.
TitleYcaO domains use ATP to activate amide backbones during peptide cyclodehydrations.
SourceNat. Chem. Biol. 8:569-575(2012).
PubMed ID22522320
DOI10.1038/nchembio.944



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