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PROSITE documentation PDOC51692 [for PROSITE entry PS51692]

Pestivirus nonstructural protein 2 (NS2) protease domain profile





Description

Pestiviruses [E1] are animal pathogens that are recognized as a separate genus of the family Flaviviridae. The pestiviral genome is a single-stranded RNA of positive polarity. It is translated into a large polyprotein, which is cotranslationally and posttranslationally processed by viral and cellular proteases. Pestivirus nonstructural protein 2 (NS2) is predicted to have a multidomain organization. The C-terminal-most domain of NS2 is a cysteine autoprotease responsible for NS2-3 cleavage. The catalytic triad is formed by His, Glu, and Cys. The pestivirus NS2 protease domain contains five Cys and one His organized in a linear fashion, suggesting the presence of a mononuclear ZnB site [1]. The pestivirus NS2 protease domain forms peptidase family C74 [E2].

The profile we developed covers the entire pestivirus NS2 protease domain.

Last update:

November 2013 / First entry.

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Technical section

PROSITE method (with tools and information) covered by this documentation:

PESTIVIRUS_NS2_PRO, PS51692; Pestivirus nonstructural protein 2 (NS2) protease domain profile  (MATRIX)


References

1AuthorsLackner T. Mueller A. Pankraz A. Becher P. Thiel H.-J. Gorbalenya A.E. Tautz N.
TitleTemporal modulation of an autoprotease is crucial for replication and pathogenicity of an RNA virus.
SourceJ. Virol. 78:10765-10775(2004).
PubMed ID15367643
DOI10.1128/JVI.78.19.10765-10775.2004

E1Titlehttps://viralzone.expasy.org/39?outline=all_by_species

E2Titlehttps://www.ebi.ac.uk/merops/cgi-bin/famsum?family=C74



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