General rule information
[?]
Accession |
PRU01029 |
Dates |
11-NOV-2013 (Created) 22-NOV-2019 (Last updated, Version 8) |
Predictors |
PROSITE; PS51692; PESTIVIRUS_NS2_PRO
|
Name |
Pestivirus nonstructural protein 2 (NS2) protease domain |
Function |
The C-terminal-most domain of NS2 is a cysteine autoprotease responsible for NS2-3 cleavage. The catalytic triad is formed by His, Glu, and Cys. The pestivirus NS2 protease domain contains five Cys and one His organized in a linear fashion, suggesting the presence of a mononuclear ZnB site. The pestivirus NS2 protease domain forms peptidase family C74. |
Propagated annotation
[?]
case <FTGroup:1>
+ Contains:
RecName: Full=Cysteine protease NS2;
EC 3.4.22.-; |
Function |
NS2 protease seems to play a vital role in viral RNA replication control and in the pathogenicity of the virus. |
Subcellular location |
Cysteine protease NS2: Host membrane; Multi-pass membrane protein. |
end case
GO:0016021; Cellular component: integral component of membrane.
case <FTGroup:1>
GO:0019082; Biological process: viral protein processing.
GO:0006508; Biological process: proteolysis.
end case
GO:0033644; Cellular component: host cell membrane.
case <FTGroup:1>
GO:0004197; Molecular function: cysteine-type endopeptidase activity.
end case
case <FTGroup:1>
end case
case <FTGroup:1>
end case
From: PS51692 |
Key
|
|
From
|
|
To
|
|
Description
|
|
Tag
|
|
Condition
|
|
FTGroup
|
TRANSMEM
|
|
128
|
|
148
|
|
Helical
|
|
|
|
|
|
|
DOMAIN
|
|
from
|
|
to
|
|
Peptidase C74 #
|
|
|
|
|
|
|
ACT_SITE
|
|
7
|
|
7
|
|
For cysteine protease NS2 activity
|
|
|
|
H
|
|
1
|
ACT_SITE
|
|
21
|
|
21
|
|
For cysteine protease NS2 activity
|
|
|
|
E
|
|
1
|
ACT_SITE
|
|
72
|
|
72
|
|
For cysteine protease NS2 activity
|
|
|
|
C
|
|
1
|
case <FTGroup:1>
CHAIN
|
|
?
|
|
149
|
|
Cysteine protease NS2
|
|
|
|
|
|
|
SITE
|
|
149
|
|
149+1
|
|
Cleavage; partial; cysteine protease NS2
|
|
|
|
|
|
|
end case
Additional information
[?]
Size range |
139-249 amino acids |
Related rules |
None |
Repeats |
1 |
Topology |
Undefined |
Example |
P19711 (POLG_BVDVN) |
Scope |
Viruses; Pestivirus |
Comments |
None |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and
distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives
(CC BY-NC-ND 4.0) License, see
prosite_license.html.
UniProtKB rule member sequences
[?]
UniProtKB/Swiss-Prot sets