 |
|
| annotation rule: PRU01029 |
General rule information
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| Accession | PRU01029 |
| Dates | 11-NOV-2013 (Created) 22-NOV-2019 (Last updated, Version 8) |
| Data class | Domain |
| Predictors | PROSITE; PS51692; PESTIVIRUS_NS2_PRO |
| Name | Pestivirus nonstructural protein 2 (NS2) protease domain |
| Function | The C-terminal-most domain of NS2 is a cysteine autoprotease responsible for NS2-3 cleavage. The catalytic triad is formed by His, Glu, and Cys. The pestivirus NS2 protease domain contains five Cys and one His organized in a linear fashion, suggesting the presence of a mononuclear ZnB site. The pestivirus NS2 protease domain forms peptidase family C74. |
Propagated annotation
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Description
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case <FTGroup:1>
| + Contains: RecName: Full=Cysteine protease NS2; EC 3.4.22.-; |
Comments
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| Function | NS2 protease seems to play a vital role in viral RNA replication control and in the pathogenicity of the virus. |
| Subcellular location | Cysteine protease NS2: Host membrane; Multi-pass membrane protein. |
end case
Gene Ontology
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GO:0016021; Cellular component: integral component of membrane.
case <FTGroup:1>
GO:0019082; Biological process: viral protein processing.
GO:0006508; Biological process: proteolysis.
GO:0006508; Biological process: proteolysis.
end case
GO:0033644; Cellular component: host cell membrane.
case <FTGroup:1>
GO:0004197; Molecular function: cysteine-type endopeptidase activity.
end case
Keywords
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case <FTGroup:1>
end case
case <FTGroup:1>
end case
Features
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| From: PS51692 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| TRANSMEM | 128 | 148 | Helical | |||||||||
| DOMAIN | from | to | Peptidase C74 # | |||||||||
| ACT_SITE | 7 | 7 | For cysteine protease NS2 activity | H | 1 | |||||||
| ACT_SITE | 21 | 21 | For cysteine protease NS2 activity | E | 1 | |||||||
| ACT_SITE | 72 | 72 | For cysteine protease NS2 activity | C | 1 | |||||||
case <FTGroup:1>
end case
Additional information
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| Size range | 139-249 amino acids |
| Related rules | None |
| Repeats | 1 |
| Topology | Undefined |
| Example | P19711 (POLG_BVDVN) |
| Scope | Viruses; Pestivirus |
| Comments | None |
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UniProtKB rule member sequences
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