|PROSITE documentation PDOC51820 [for PROSITE entry PS51820]|
The ~150-amino acid PA14 domain, named after its location in the protective antigen of anthrax toxin, is found in a variety of bacterial and eukaryotic proteins such as glycosidases, glycosyltransferases, proteases, amidases, toxins, adhesins and signaling molecules. The PA14 domain is combined in a mosaic manner with various catalytic or non-catalytic domains directly or indirectly implicated in binding carbohydrate or peptidoglycan. It could be a carbohydrate-binding module [1,2,3].
The PA14 domain is a β-barrel structure comprising two β-sheets (see <PDB:1ACC>). The N and C termini of the domain are close together in space, presumably, thereby facilitating the insertion of the PA14 domain into other recognized domains without structural disruption [1,2,3].
The profile we developed covers the entire PA14 domain.Last update:
November 2016 / First entry.
PROSITE method (with tools and information) covered by this documentation:
|1||Authors||Rigden D.J. Mello L.V. Galperin M.Y.|
|Title||The PA14 domain, a conserved all-beta domain in bacterial toxins, enzymes, adhesins and signaling molecules.|
|Source||Trends Biochem. Sci. 29:335-339(2004).|
|2||Authors||Yoshida E. Hidaka M. Fushinobu S. Koyanagi T. Minami H. Tamaki H. Kitaoka M. Katayama T. Kumagai H.|
|Title||Role of a PA14 domain in determining substrate specificity of a glycoside hydrolase family 3 beta-glucosidase from Kluyveromyces marxianus.|
|Source||Biochem. J. 431:39-49(2010).|
|3||Authors||Petosa C. Collier R.J. Klimpel K.R. Leppla S.H. Liddington R.C.|
|Title||Crystal structure of the anthrax toxin protective antigen.|