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PROSITE documentation PDOC51893 [for PROSITE entry PS51893]

A kinase-anchoring proteins AKAP-5 and AKAP-12 calmodulin (CaM)-binding motif profile





Description

The A kinase-anchoring proteins AKAP-5 and AKAP-12 (Gravin) bind calmodulin (CaM), a Ca(2+)-sensing protein that is expressed in all eukaryotic cells and mediates many essential processes driven by Ca(2+), including long-term changes in synaptic connections in the brain, apoptosis, and immune responses. The AKAP CaM-binding motif contains hydrophobic amino acids in a 1-4-7-8 pattern within an helix (see <PDB:5NIN>) [1].

The profile we developed covers the entire AKAP CaM-binding motif.

Last update:

April 2019 / First entry.

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Technical section

PROSITE method (with tools and information) covered by this documentation:

AKAP_CAM_BD, PS51893; A kinase-anchoring proteins AKAP-5 and AKAP-12 calmodulin (CaM)-binding motif profile  (MATRIX)


Reference

1AuthorsPatel N. Stengel F. Aebersold R. Gold M.G.
TitleMolecular basis of AKAP79 regulation by calmodulin.
SourceNat. Commun. 8:1681-1681(2017).
PubMed ID29162807
DOI10.1038/s41467-017-01715-w



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