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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00071


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00071
General rule information [?]

Accession PRU00071
Dates 12-DEC-2003 (Created)
19-NOV-2022 (Last updated, Version 17)
Data class Domain;
Predictors PROSITE; PS50884; ZF_DOF_2
Name Zinc finger Dof-type
Function Like other zinc fingers the Dof domain has a dual activity: it binds DNA in a sequence-specific manner with the core binding site formed by the AAAG sequence and it can also mediates protein-protein interaction.
Scope(s) Eukaryota
Magnoliopsida
Example(s) Q43385;

Propagated annotation [?]

Comments [?]

SUBCELLULAR LOCATIONNucleus.

Keywords [?]

Nucleus
DNA-binding
Zinc-finger
case <Feature:PS50884:3=[CH]> and <Feature:PS50884:6=[CH]> and <Feature:PS50884:28=[CH]> and <Feature:PS50884:31=[CH]>
Zinc
Metal-binding
end case

Gene Ontology [?]

GO:0003677; Molecular function:DNA binding
GO:0005634; Cellular component:nucleus

Cross-references [?]

PROSITE PS01361; ZF_DOF_1; 1;

Features [?]

From: PS50884
Key From To Description Tag Condition FTGroup
case <Feature:PS50884:3=[C]> and <Feature:PS50884:6=[C]> and <Feature:PS50884:28=[C]> and <Feature:PS50884:31=[C]>
ZN_FING from to /note="Dof-type #"
else case <Feature:PS50884:3=[CH]> and <Feature:PS50884:6=[CH]> and <Feature:PS50884:28=[CH]> and <Feature:PS50884:31=[CH]>
ZN_FING from to /note="Dof-type #; atypical"
else
ZN_FING from to /note="Dof-type #; degenerate"
end case
BINDING 3 3 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 6 6 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 28 28 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 31 31 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1

Additional information [?]

Size range 55-55 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]