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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00073


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00073
General rule information [?]

Accession PRU00073
Dates 12-DEC-2003 (Created)
08-APR-2020 (Last updated, Version 7)
Data class Domain;
Predictors PROSITE; PS50139; Z_BINDING
Name Z-binding domain
Function The Z-binding domain (ZBD), also referred to as Zalpha or Zbeta is a 78-amino-acid protein fold that specifically binds to Z-DNA as well as to Z- RNA but not to B-DNA. ZBDs might play an important role of in innate antiviral immune responses.
Scope(s) Eukaryota
Eutheria
Viruses
Orthopoxvirus
Example(s) Q99MU3;

Propagated annotation [?]

Features [?]

From: PS50139
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Z-binding #"

Additional information [?]

Size range 66-70 amino acids
Related rules None
Fusion None
Repeats 1-2
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]