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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00099


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00099
General rule information [?]

Accession PRU00099
Dates 12-DEC-2003 (Created)
19-NOV-2022 (Last updated, Version 17)
Data class Domain;
Predictors PROSITE; PS50125; GUANYLATE_CYCLASE_2
Name Guanylate cyclase domain
Function Undefined
Scope(s) Eukaryota
Bacteria
Example(s) P32870;

Propagated annotation [?]

Comments [?]

SIMILARITYBelongs to the adenylyl cyclase class-4/guanylyl cyclase family.

Keywords [?]

case <FTGroup:1>
Magnesium
Metal-binding
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0000287; Molecular function:magnesium ion binding
end case

Cross-references [?]

PROSITE PS00452; GUANYLATE_CYCLASE_1; 1;

Features [?]

From: PS50125
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Guanylate cyclase #"
BINDING 6 6 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
/ligand_label="1"		 D 1
BINDING 6 6 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
/ligand_label="2"		 D 1
BINDING 7 7 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
/ligand_label="2"		 I 1
BINDING 50 50 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
/ligand_label="1"		 D 1
BINDING 50 50 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
/ligand_label="2"		 D 1

Additional information [?]

Size range 108-134 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]