ProRule PRU00107
General rule information
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| PURL | https://purl.expasy.org/prosite/rule/PRU00107 |
| Accession | PRU00107 |
| Dates | 12-DEC-2003 (Created)
20-NOV-2019 (Last updated, Version 12) |
| Data class | Domain; |
| Predictors |
PROSITE; PS50109; HIS_KIN |
Name | Histidine kinase core domain |
| Function | Autophosphorylates at a histidine residue, creating a high-energy phosphoryl group that is subsequently transferred to a phosphoacceptor. |
| Scope(s) |
Eukaryota Bacteria Archaea Viruses Plastid Mitochondrion |
| Example(s) | P59963 (MTRB_MYCBO); |
Propagated annotation
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Keywords
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| Transferase | |
| Kinase | |
| case <FT:2> | |
| Phosphoprotein | |
| end case | |
Gene Ontology
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| GO:0016740; Molecular function:transferase activity |
| GO:0016301; Molecular function:kinase activity |
Features
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| From: PS50109 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="Histidine kinase #" | |||||||||
| MOD_RES | 4 | 4 | /note="Phosphohistidine; by autocatalysis" | H | ||||||||
Additional information
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| Size range | 157-356 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Cytoplasmic |
| Comments | Mitochondrial pyruvate dehydrogenase kinases (PDKs) (EC 2.7.1.99) contain an histidine kinase domain which possess a serine/threonine kinase activity. |
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UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Archaea [3] Bacteria [495] Eukaryota [134] All [ 632 ]
- Retrieve set of proteins with 3D structure for this domain