PRU00107
General rule information
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| Accession | PRU00107 |
| Dates | 12-DEC-2003 (Created) 20-NOV-2019 (Last updated, Version 12) |
| Data class | Domain |
| Predictors | PROSITE; PS50109; HIS_KIN |
| Name | Histidine kinase core domain |
| Function | Autophosphorylates at a histidine residue, creating a high-energy phosphoryl group that is subsequently transferred to a phosphoacceptor. |
Propagated annotation
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Gene Ontology
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GO:0016740; Molecular function: transferase activity.
GO:0016301; Molecular function: kinase activity.
GO:0016301; Molecular function: kinase activity.
Keywords
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case <FT:2>
end case
Features
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| From: PS50109 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | Histidine kinase # | |||||||||
| MOD_RES | 4 | 4 | Phosphohistidine; by autocatalysis | H | ||||||||
Additional information
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| Size range | 157-356 amino acids |
| Related rules | None |
| Repeats | 1 |
| Topology | Cytoplasmic |
| Example | P59963 (MTRB_MYCBO) |
| Scope | Eukaryota
Bacteria
Archaea
Viruses
Plastid
Mitochondrion |
| Comments | Mitochondrial pyruvate dehydrogenase kinases (PDKs) (EC 2.7.1.99) contain an histidine kinase domain which possess a serine/threonine kinase activity. |
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UniProtKB rule member sequences
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-
UniProtKB/Swiss-Prot sets
Archaea [3] Bacteria [488] Eukaryota [133] All [ 624 ]
- Retrieve set of proteins with 3D structure for this domain