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annotation rule: PRU00107

General rule information [?]

Accession PRU00107
Dates 12-DEC-2003 (Created)
12-MAR-2018 (Last updated, Version 11)
Data class Domain
Predictors PROSITE; PS50109; HIS_KIN
Name Histidine kinase core domain
Function Autophosphorylates at a histidine residue, creating a high-energy phosphoryl group that is subsequently transferred to a phosphoacceptor.

Propagated annotation [?]


Gene Ontology [?]

GO:0016740; Molecular function: transferase activity.
GO:0016301; Molecular function: kinase activity.

Keywords [?]

case <FT:2>
end case


Features [?]

From: PS50109
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       Histidine kinase #        
MOD_RES     4     4       Phosphohistidine; by autocatalysis     H  

Additional information [?]

Size range 157-356 amino acids
Related rules None
Repeats 1
Topology Cytoplasmic
Example P59963 (MTRB_MYCBO)
Scope
Eukaryota
Bacteria
Archaea
Viruses
Plastid
Mitochondrion
Comments Mitochondrial pyruvate dehydrogenase kinases (PDKs) (EC 2.7.1.99) contain an histidine kinase domain which possess a serine/threonine kinase activity.

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



UniProtKB rule member sequences [?]