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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00107


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00107
General rule information [?]

Accession PRU00107
Dates 12-DEC-2003 (Created)
20-NOV-2019 (Last updated, Version 13)
Data class Domain;
Predictors PROSITE; PS50109; HIS_KIN
Name Histidine kinase core domain
Function Autophosphorylates at a histidine residue, creating a high-energy phosphoryl group that is subsequently transferred to a phosphoacceptor.
Scope(s) Eukaryota
Bacteria
Archaea
Viruses
Plastid
Mitochondrion
Example(s) P59963;

Propagated annotation [?]

Keywords [?]

Transferase
Kinase
case <FT:2>
Phosphoprotein
end case

Gene Ontology [?]

GO:0016740; Molecular function:transferase activity
GO:0016301; Molecular function:kinase activity

Features [?]

From: PS50109
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Histidine kinase #"
MOD_RES 4 4 /note="Phosphohistidine; by autocatalysis" H

Additional information [?]

Size range 157-356 amino acids
Related rules None
Fusion None
Repeats 1
Topology Cytoplasmic
Comments Mitochondrial pyruvate dehydrogenase kinases (PDKs) (EC 2.7.1.99) contain an histidine kinase domain which possess a serine/threonine kinase activity.

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]