PRU00107
General rule information
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Accession | PRU00107 |
Dates | 12-DEC-2003 (Created) 20-NOV-2019 (Last updated, Version 12) |
Data class | Domain |
Predictors | PROSITE; PS50109; HIS_KIN |
Name | Histidine kinase core domain |
Function | Autophosphorylates at a histidine residue, creating a high-energy phosphoryl group that is subsequently transferred to a phosphoacceptor. |
Propagated annotation
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Gene Ontology
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GO:0016740; Molecular function: transferase activity.
GO:0016301; Molecular function: kinase activity.
GO:0016301; Molecular function: kinase activity.
Keywords
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case <FT:2>
end case
Features
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From: PS50109 | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
DOMAIN | from | to | Histidine kinase # | |||||||||
MOD_RES | 4 | 4 | Phosphohistidine; by autocatalysis | H |
Additional information
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Size range | 157-356 amino acids |
Related rules | None |
Repeats | 1 |
Topology | Cytoplasmic |
Example | P59963 (MTRB_MYCBO) |
Scope | Eukaryota
Bacteria
Archaea
Viruses
Plastid
Mitochondrion |
Comments | Mitochondrial pyruvate dehydrogenase kinases (PDKs) (EC 2.7.1.99) contain an histidine kinase domain which possess a serine/threonine kinase activity. |
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UniProtKB rule member sequences
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-
UniProtKB/Swiss-Prot sets
Archaea [3] Bacteria [488] Eukaryota [133] All [ 624 ]
- Retrieve set of proteins with 3D structure for this domain