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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00111


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00111
General rule information [?]

Accession PRU00111
Dates 12-DEC-2003 (Created)
27-JUN-2022 (Last updated, Version 12)
Data class Domain;
Predictors PROSITE; PS50932; HTH_LACI_2
Name LacI-type HTH domain
Function The lacI-type HTH domain is a DNA-binding, helix-turn-helix (HTH) domain present in the lacI/galR family of transcriptional regulators involved in metabolic regulation in prokaryotes.
Scope(s) Bacteria
Example(s) P44329;

Propagated annotation [?]

Keywords [?]

DNA-binding
Transcription
Transcription regulation

Gene Ontology [?]

GO:0003677; Molecular function:DNA binding
GO:0006355; Biological process:regulation of DNA-templated transcription
GO:0006351; Biological process:DNA-templated transcription

Cross-references [?]

PROSITE PS00356; HTH_LACI_1; 1;

Features [?]

From: PS50932
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="HTH lacI-type #"
DNA_BIND 3 22 /note="H-T-H motif"

Additional information [?]

Size range 54-62 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]