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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00146


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00146
General rule information [?]

Accession PRU00146
Dates 12-DEC-2003 (Created)
19-NOV-2022 (Last updated, Version 13)
Data class Domain;
Predictors PROSITE; PS50016; ZF_PHD_2
Name Zinc finger PHD-type
Function Undefined
Scope(s) Eukaryota
Example(s) P55197;

Propagated annotation [?]

Keywords [?]

Zinc-finger
case (<Feature:PS50016:4=[CH]> and <Feature:PS50016:7=[CH]> and <Feature:PS50016:28=[CH]> and <Feature:PS50016:31=[CH]>) or (<Feature:PS50016:20=[CH]> and <Feature:PS50016:23=[CH]> and <Feature:PS50016:48=[CH]> and <Feature:PS50016:51=[CH]>)
Zinc
Metal-binding
end case

Cross-references [?]

PROSITE PS01359; ZF_PHD_1; 1;

Features [?]

From: PS50016
Key From To Description Tag Condition FTGroup
case (<Feature:PS50016:4=[C]> and <Feature:PS50016:7=[C]> and <Feature:PS50016:28=[H]> and <Feature:PS50016:31=[C]>) and (<Feature:PS50016:20=[C]> and <Feature:PS50016:23=[C]> and <Feature:PS50016:48=[C]> and <Feature:PS50016:51=[C]>)
ZN_FING from to /note="PHD-type #"
else case (<Feature:PS50016:4=[CH]> and <Feature:PS50016:7=[CH]> and <Feature:PS50016:28=[CH]> and <Feature:PS50016:31=[CH]>) and (<Feature:PS50016:20=[CH]> and <Feature:PS50016:23=[CH]> and <Feature:PS50016:48=[CH]> and <Feature:PS50016:51=[CH]>)
ZN_FING from to /note="PHD-type #; atypical"
else
ZN_FING from to /note="PHD-type #; degenerate"
end case
BINDING 4 4 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 7 7 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 20 20 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 [CH] 2
BINDING 23 23 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 [CH] 2
BINDING 28 28 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 31 31 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 48 48 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 [CH] 2
BINDING 51 51 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 [CH] 2

Additional information [?]

Size range 34-89 amino acids
Related rules None
Fusion None
Repeats 1-6
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]