We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU00159
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00159
General rule information
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| Accession | PRU00159 |
| Dates | 12-DEC-2003 (Created)
19-NOV-2022 (Last updated, Version 48) |
| Data class | Domain; |
| Predictors |
PROSITE; PS50011; PROTEIN_KINASE_DOM |
Name | Protein kinase domain |
| Function | Undefined |
| Scope(s) |
Eukaryota Bacteria Viruses |
| Example(s) | O54967; |
Propagated annotation
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Identifier, protein and gene names
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| case <Feature:PS00108> | |
| Protein name | + AltName: EC=2.7.11.-; |
| else case <Feature:PS00109> | |
| Protein name | + AltName: EC=2.7.10.-; |
| else case <FT:4> | |
| Protein name | + AltName: EC=2.7.-.-; |
| end case | |
| case <Feature:PS00108> | |
| else case <Feature:PS00109> and <AnyFeature:PS51550> | |
Comments
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| case <Feature:PS00108> | |
| else case <Feature:PS00109> | |
| case not <FTTag:active> | |
| DOMAIN | The protein kinase domain is predicted to be catalytically inactive. |
| end case | |
| case <Feature:PS00108> | |
| SIMILARITY | Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. |
| else case <Feature:PS00109> and <AnyFeature:PS51550> | |
| SIMILARITY | Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. |
| else case <Feature:PS00109> | |
| SIMILARITY | Belongs to the protein kinase superfamily. Tyr protein kinase family. |
| end case | |
Keywords
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| case <Feature:PS00108> | |
| Kinase | |
| Transferase | |
| Serine/threonine-protein kinase | |
| else case <Feature:PS00109> | |
| Kinase | |
| Transferase | |
| Tyrosine-protein kinase | |
| end case | |
| case <FTTag:ATP> | |
| ATP-binding | |
| Nucleotide-binding | |
| end case | |
Gene Ontology
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| case <Feature:PS00108> | |
| GO:0016301; Molecular function:kinase activity | |
| GO:0016740; Molecular function:transferase activity | |
| GO:0004674; Molecular function:protein serine/threonine kinase activity | |
| else case <Feature:PS00109> | |
| GO:0016301; Molecular function:kinase activity | |
| GO:0016740; Molecular function:transferase activity | |
| GO:0004713; Molecular function:protein tyrosine kinase activity | |
| end case | |
| case <FTTag:ATP> | |
| GO:0005524; Molecular function:ATP binding | |
| GO:0000166; Molecular function:nucleotide binding | |
| end case | |
Cross-references
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| PROSITE | PS00107; PROTEIN_KINASE_ATP; 1; |
| PROSITE | PS00107; PROTEIN_KINASE_ATP; 1; |
| PROSITE | PS00108; PROTEIN_KINASE_ST; 1; |
| PROSITE | PS00109; PROTEIN_KINASE_TYR; 1; |
Features
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| case <Feature:PS00108> | ||||||||||||
| From: PS50011 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="Protein kinase #" | |||||||||
| case <Feature:PS50011:30=K> or <Feature:PS00107> | ||||||||||||
| BINDING | 7 | 15 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
ATP | ||||||||
| end case | ||||||||||||
| case <Feature:PS50011:30=K> | ||||||||||||
| BINDING | 30 | 30 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
|||||||||
| end case | ||||||||||||
| case <FTTag:ATP> | ||||||||||||
| ACT_SITE | 124 | 124 | /note="Proton acceptor" | active | D | |||||||
| end case | ||||||||||||
Additional information
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| Size range | 205-549 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1-2 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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