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annotation rule: PRU00159

General rule information [?]

Accession PRU00159
Dates 12-DEC-2003 (Created)
14-MAY-2022 (Last updated, Version 46)
Data class Domain
Predictors PROSITE; PS50011; PROTEIN_KINASE_DOM
Name Protein kinase domain
Function Undefined.

Propagated annotation [?]


Description [?]

case <Feature:PS00108>
+ AltName: EC 2.7.11.-;
else case <Feature:PS00109>
+ AltName: EC 2.7.10.-;
else case <FT:4>
+ AltName: EC 2.7.-.-;
end case


Comments [?]

case not <FTTag:active>
Domain The protein kinase domain is predicted to be catalytically inactive.
end case

case <Feature:PS00108>
Similarity Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
else case <Feature:PS00109> and <AnyFeature:PS51550>
Similarity Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
else case <Feature:PS00109>
Similarity Belongs to the protein kinase superfamily. Tyr protein kinase family.
end case


Cross-references [?]

case <FT:3>
PROSITE PS00107; PROTEIN_KINASE_ATP; 1; trigger=PRU10141;
else case <Feature:PS00107>
PS00107; PROTEIN_KINASE_ATP; 1; trigger=PRU10141;
end case

case <Feature:PS00108>
PROSITE PS00108; PROTEIN_KINASE_ST; 1;
else case <Feature:PS00109>
PS00109; PROTEIN_KINASE_TYR; 1;
end case


Gene Ontology [?]

case <Feature:PS00108>
GO:0016301; Molecular function: kinase activity.
GO:0016740; Molecular function: transferase activity.
GO:0004674; Molecular function: protein serine/threonine kinase activity.

Keywords [?]

Kinase
Transferase
Serine/threonine-protein kinase

Gene Ontology [?]

else case <Feature:PS00109>
GO:0016301; Molecular function: kinase activity.
GO:0016740; Molecular function: transferase activity.
GO:0004713; Molecular function: protein tyrosine kinase activity.

Keywords [?]

Kinase
Transferase
Tyrosine-protein kinase
end case


Gene Ontology [?]

case <FTTag:ATP>
GO:0005524; Molecular function: ATP binding.
GO:0000166; Molecular function: nucleotide binding.

Keywords [?]

ATP-binding
Nucleotide-binding
end case


Features [?]

From: PS50011
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       Protein kinase #        
case <Feature:PS50011:30=K> or <Feature:PS00107>
BINDING     7     15       /ligand="ATP" /ligand_id="30616   ATP      
end case

case <Feature:PS50011:30=K>
BINDING     30     30       /ligand="ATP" /ligand_id="30616        
end case

case <FTTag:ATP>
ACT_SITE     124     124       Proton acceptor   active   D  
end case


Additional information [?]

Size range 205-549 amino acids
Related rules None
Repeats 1-2
Topology Undefined
Example O54967 (ACK1_MOUSE)
Scope
Eukaryota
Bacteria
Viruses

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.


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UniProtKB rule member sequences [?]