ProRule PRU00159
General rule information
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| PURL | https://purl.expasy.org/prosite/rule/PRU00159 |
| Accession | PRU00159 |
| Dates | 12-DEC-2003 (Created)
19-NOV-2022 (Last updated, Version 47) |
| Data class | Domain; |
| Predictors |
PROSITE; PS50011; PROTEIN_KINASE_DOM |
Name | Protein kinase domain |
| Function | Undefined |
| Scope(s) |
Eukaryota Bacteria Viruses |
| Example(s) | O54967 (ACK1_MOUSE); |
Propagated annotation
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Identifier, protein and gene names
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| case <Feature:PS00108> | |
| Protein name | + AltName: EC=2.7.11.-; |
| else case <Feature:PS00109> | |
| Protein name | + AltName: EC=2.7.10.-; |
| else case <FT:4> | |
| Protein name | + AltName: EC=2.7.-.-; |
| end case | |
| case <Feature:PS00108> | |
| else case <Feature:PS00109> and <AnyFeature:PS51550> | |
Comments
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| case <Feature:PS00108> | |
| else case <Feature:PS00109> | |
| case not <FTTag:active> | |
| DOMAIN | The protein kinase domain is predicted to be catalytically inactive. |
| end case | |
| case <Feature:PS00108> | |
| SIMILARITY | Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. |
| else case <Feature:PS00109> and <AnyFeature:PS51550> | |
| SIMILARITY | Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. |
| else case <Feature:PS00109> | |
| SIMILARITY | Belongs to the protein kinase superfamily. Tyr protein kinase family. |
| end case | |
Keywords
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| case <Feature:PS00108> | |
| Kinase | |
| Transferase | |
| Serine/threonine-protein kinase | |
| else case <Feature:PS00109> | |
| Kinase | |
| Transferase | |
| Tyrosine-protein kinase | |
| end case | |
| case <FTTag:ATP> | |
| ATP-binding | |
| Nucleotide-binding | |
| end case | |
Gene Ontology
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| case <Feature:PS00108> | |
| GO:0016301; Molecular function:kinase activity | |
| GO:0016740; Molecular function:transferase activity | |
| GO:0004674; Molecular function:protein serine/threonine kinase activity | |
| else case <Feature:PS00109> | |
| GO:0016301; Molecular function:kinase activity | |
| GO:0016740; Molecular function:transferase activity | |
| GO:0004713; Molecular function:protein tyrosine kinase activity | |
| end case | |
| case <FTTag:ATP> | |
| GO:0005524; Molecular function:ATP binding | |
| GO:0000166; Molecular function:nucleotide binding | |
| end case | |
Cross-references
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| PROSITE | PS00107; PROTEIN_KINASE_ATP; 1; |
| PROSITE | PS00107; PROTEIN_KINASE_ATP; 1; |
| PROSITE | PS00108; PROTEIN_KINASE_ST; 1; |
| PROSITE | PS00109; PROTEIN_KINASE_TYR; 1; |
Features
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| case <Feature:PS00108> | ||||||||||||
| From: PS50011 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="Protein kinase #" | |||||||||
| case <Feature:PS50011:30=K> or <Feature:PS00107> | ||||||||||||
| BINDING | 7 | 15 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
ATP | ||||||||
| end case | ||||||||||||
| case <Feature:PS50011:30=K> | ||||||||||||
| BINDING | 30 | 30 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
|||||||||
| end case | ||||||||||||
| case <FTTag:ATP> | ||||||||||||
| ACT_SITE | 124 | 124 | /note="Proton acceptor" | active | D | |||||||
| end case | ||||||||||||
Additional information
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| Size range | 205-549 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1-2 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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