annotation rule: PRU00159

General rule information [?]

Accession PRU00159
Dates 12-DEC-2003 (Created)
7-JAN-2017 (Last updated, Version 40)
Data class Domain
Predictors PROSITE; PS50011; PROTEIN_KINASE_DOM
Name Protein kinase domain
Function Undefined.

Propagated annotation [?]


Description [?]

case <Feature:PS00108>
+ RecName: EC=2.7.11.-;
else case <Feature:PS00109>
+ RecName: EC=2.7.10.-;
else case <FT:4>
+ RecName: EC=2.7.-.-;
end case


Comments [?]

case not <FTTag:active>
Domain The protein kinase domain is predicted to be catalytically inactive.
end case

case <Feature:PS00108>
Similarity Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
else case <Feature:PS00109> and <AnyFeature:PS51550>
Similarity Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
else case <Feature:PS00109>
Similarity Belongs to the protein kinase superfamily. Tyr protein kinase family.
end case


Cross-references [?]

case <Feature:PS50011:30=K>
PROSITE PS00107; PROTEIN_KINASE_ATP; 1;
end case

case <Feature:PS00108>
PROSITE PS00108; PROTEIN_KINASE_ST; 1;
else case <Feature:PS00109>
PS00109; PROTEIN_KINASE_TYR; 1;
end case


Gene Ontology [?]

case <Feature:PS00108>
GO:0016301; Molecular function: kinase activity.
GO:0016740; Molecular function: transferase activity.
GO:0004674; Molecular function: protein serine/threonine kinase activity.

Keywords [?]

Kinase
Transferase
Serine/threonine-protein kinase

Gene Ontology [?]

else case <Feature:PS00109>
GO:0016301; Molecular function: kinase activity.
GO:0016740; Molecular function: transferase activity.
GO:0004713; Molecular function: protein tyrosine kinase activity.

Keywords [?]

Kinase
Transferase
Tyrosine-protein kinase
end case


Gene Ontology [?]

case <Feature:PS50011:30=K>
GO:0005524; Molecular function: ATP binding.
GO:0000166; Molecular function: nucleotide binding.

Keywords [?]

ATP-binding
Nucleotide-binding
end case


Features [?]

From: PS50011
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       Protein kinase #        
NP_BIND     7     15       ATP     x*   1
BINDING     30     30       ATP     K   1
case <FTGroup:1>
ACT_SITE     124     124       Proton acceptor   active   D  
end case


Additional information [?]

Size range 205-549 amino acids
Related rules None
Repeats 1-2
Topology Undefined
Example O54967 (ACK1_MOUSE)
Scope Eukaryota
Bacteria
Viruses

Copyright

PROSITE is copyright. It is produced by the SIB Swiss Institute Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified. Usage by and for commercial entities requires a license agreement. For information about the licensing scheme send an email to license@isb-sib.ch or see: prosite_license.html.


View rule in raw text format (no links)


UniProtKB rule member sequences [?]