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ProRule PRU00167


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PURL: https://purl.expasy.org/prosite/rule/PRU00167
General rule information [?]

Accession PRU00167
Dates 12-DEC-2003 (Created)
20-MAR-2025 (Last updated, Version 8)
Data class Domain;
Predictors PROSITE; PS50018; RAS_GTPASE_ACTIV_2
Name Ras-GAP domain
Function Ras proteins are membrane-associated molecular switches that bind GTP and GDP and slowly hydrolyze GTP to GDP. This intrinsic GTPase activity of ras is stimulated by a family of proteins collectively known as 'GAP' or GTPase-activating proteins. The key residue for GAP-mediated catalysis is the so-called "arginine finger".
Scope(s) Eukaryota
Example(s) P21359 (NF1_HUMAN);

Propagated annotation [?]

Keywords [?]

GTPase activation
end case

Gene Ontology [?]

case <Feature:PS50018:26=R>
GO:0005096; Molecular function:GTPase activator activity

Cross-references [?]

PROSITE PS00509; RAS_GTPASE_ACTIV_1; 1;

Features [?]

From: PS50018
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Ras-GAP #"
SITE 26 26 /note="Arginine finger; crucial for GTP hydrolysis by stabilizing the transition state" R

Additional information [?]

Size range 190-234 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

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UniProtKB rule member sequences [?]