PROSITE entry PS50018
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PURL: https://purl.expasy.org/prosite/signature/PS50018
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General information about the entry
| Entry name [info] | RAS_GTPASE_ACTIV_2 |
| Accession [info] | PS50018 |
| Entry type [info] | MATRIX |
| Date [info] |
01-NOV-1995 CREATED;
18-JUN-2025 DATA UPDATE; 18-JUN-2025 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC00438 |
| Associated ProRule [info] | PRU00167 |
Name and characterization of the entry
| Description [info] | Ras GTPase-activating proteins (rasGAP) domain profile. |
| Matrix / Profile [info] |
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=225; /DISJOINT: DEFINITION=PROTECT; N1=6; N2=220; /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.8049119; R2=0.0088608; TEXT='-LogE'; /CUT_OFF: LEVEL=0; SCORE=1038; N_SCORE=11.0; MODE=1; TEXT='!'; /CUT_OFF: LEVEL=-1; SCORE=530; N_SCORE=6.5; MODE=1; TEXT='?'; /DEFAULT: M0=-30; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380; ... A C D E F G H I K L M N P Q R S T V W Y /I: B1=0; BI=-380; BD=-380; /M: SY='N'; M= -28, -74, -3, 2, 9, 40, 43, -67, -18, -16, -61, 44, 3, -57, -63, 17, -57, -19, -70, 34; /M: SY='L'; M= -15, -72, -71, -62, -49, -76, -60, -47, 45, 58, -43, -67, -76, -56, 30, -25, -60, -11, -66, 40; /M: SY='L'; M= 26, -5, -74, -20, 4, -74, -69, 36, -66, 52, -41, -70, -75, -9, -6, -27, -1, -6, -73, -56; /M: SY='L'; M= 0, -72, 25, -59, -55, -16, 25, -49, 16, 50, -46, -60, -73, 0, -21, -19, -3, -1, -73, 14; /M: SY='Q'; M= -11, -78, 17, -25, -75, -30, -57, -10, 10, -33, -62, -54, 48, 68, 35, 27, -56, -67, -75, -18; /M: SY='F'; M= -30, -69, -82, -76, 72, -80, -70, -19, -75, 56, -39, -76, -81, -75, -74, -12, -20, 32, -62, -41; /M: SY='L'; M= -40, -70, -84, -78, 44, -85, -73, 42, -77, 53, -37, -79, -81, -75, -76, -72, -59, 48, -67, -1; /M: SY='C'; M= -29, 76, 8, -54, -72, -66, -63, -73, 31, -72, -66, -52, -69, 4, 41, 37, 47, -67, 52, -64; /M: SY='Y'; M= 2, -73, 40, 26, -57, -66, -52, -64, -54, -1, 3, 34, -69, 22, -19, -8, 30, -63, -68, 58; /M: SY='L'; M= 14, -68, -78, -72, -49, -75, 21, 4, -72, 62, 58, -72, -77, -65, -71, -4, -57, 23, -76, -55; /M: SY='I'; M= 9, -70, -73, -72, 23, -24, -68, 55, -26, 37, -7, 11, -74, -67, -70, -10, -1, -16, -69, -8; /M: SY='Q'; M= -36, -76, 19, 37, -74, -27, -55, -69, 35, -68, 32, -51, -64, 63, 15, 10, 20, -33, -76, -10; /M: SY='N'; M= -6, -73, -55, 30, 4, -69, 15, -11, 26, 25, -53, 39, -69, 30, 8, -8, -18, -59, -75, -58; /M: SY='E'; M= -14, -79, 11, 97, -84, -71, -53, -82, -43, -76, -70, -12, -58, 50, -51, -23, -59, -75, -80, -71; /M: SY='I'; M= -20, -72, -82, -76, 9, -83, -71, 58, -74, 46, 33, -76, -78, -11, -74, -70, -59, 36, -69, 12; /M: SY='K'; M= 20, -71, 24, 27, -1, -40, -58, -65, 48, -4, -61, 21, -67, -50, -34, 26, -54, -25, -74, -6; /I: I=-42; MI=0; MD=-106; IM=0; DM=-106; /M: SY='R'; M= -28, -74, -8, 20, -68, -35, 23, -64, 36, 12, 9, -10, -69, -47, 59, 19, -25, -30, -78, -62; /M: SY='C'; M= 17, 46, -65, -19, -26, -6, -70, 1, -25, -12, -55, -12, -70, -63, -68, 28, 45, 37, -81, -65; /M: SY='D'; M= 1, -74, 56, 11, -79, 5, 4, -76, 9, -75, 9, 34, 12, 30, -56, 32, -27, -72, -84, -68; /M: SY='Q'; M= -57, -75, 53, 36, -77, -21, -55, -69, -49, -25, -65, 29, -66, 57, 0, 37, -15, -11, -84, -67; /M: SY='P'; M= 13, -74, -31, -25, 5, -31, -27, 8, -60, -55, 68, -28, 69, -21, 1, 2, -28, 9, -75, -61; /M: SY='Q'; M= -61, -76, 7, 35, -76, -7, -7, -14, -43, -38, -62, 60, -68, 60, 45, -51, 13, -69, -81, -66; /M: SY='T'; M= -10, -70, 55, -17, -73, -30, 13, -34, -52, -31, -63, -47, -65, 9, 22, 20, 69, -46, -86, -65; /I: I=-45; MI=0; MD=-115; IM=0; DM=-115; /M: SY='L'; M= -66, -72, -85, -79, 22, -86, -73, 62, -77, 65, 28, -79, -79, -73, -77, -74, -31, -12, -69, -50; /M: SY='F'; M= -69, -70, -86, -79, 89, -84, -68, -37, -77, 57, 24, -79, -84, -78, -75, -74, -63, 11, -55, -34; /M: SY='R'; M= -28, -79, 0, -50, -76, -72, -54, -79, -7, -74, -64, -53, -72, 12, 102, -11, 17, -72, -78, -63; /M: SY='G'; M= 6, -73, -3, 12, -78, 64, -62, -77, 11, -77, -69, 30, -67, -54, 15, 3, -5, -29, -79, -72; /M: SY='N'; M= -61, -71, 34, 17, -79, -8, -47, -78, -47, -81, -71, 104, -69, -8, -1, -17, -11, -77, -91, -71; /M: SY='S'; M= -47, 22, -58, -59, -72, -58, -64, -68, -58, -72, -66, -48, 28, -56, -65, 80, 74, -60, -85, -68; /M: SY='C'; M= -16, 57, -74, -69, -54, -74, -70, 16, -69, 53, -43, -68, -15, 8, -71, 18, 18, 15, -78, -61; /M: SY='A'; M= 64, -66, -71, -67, 18, -61, -72, 2, -66, -30, -54, 1, -71, -65, -70, 5, -22, 42, 44, -58; /M: SY='S'; M= -52, -68, -62, -62, 26, -30, -66, -2, -12, -64, -62, -12, 13, -59, -64, 66, 59, -25, 50, -56; /M: SY='K'; M= -17, -74, -56, -46, -75, -67, -57, -73, 83, -28, -62, 5, -65, 24, 35, -3, 20, -68, -75, -65; /M: SY='M'; M= 14, 40, -68, -66, -61, -66, -62, 26, -58, 6, 76, 2, -71, -58, 24, 41, -1, -48, -78, -61; /M: SY='M'; M= -64, -71, -82, -30, 31, -84, -70, 56, -74, 44, 77, -77, -77, -70, -74, -73, -60, 23, -70, -49; /M: SY='E'; M= -59, -74, 33, 51, 19, -2, -60, -1, -58, -19, -58, -56, -67, -55, -64, -6, 35, 8, -68, 41; /M: SY='Q'; M= -16, -74, 0, 45, 1, -18, -57, -70, 32, -25, -1, -52, -64, 61, -14, 21, 18, -67, -75, -62; /M: SY='Y'; M= -43, 28, -3, -70, 58, -78, 7, 5, -66, -2, 14, -67, -80, -66, -7, -50, -18, -54, -46, 94; /M: SY='M'; M= -32, -69, -70, -70, 63, -73, -59, -46, -63, 19, 86, 36, -75, -64, -8, -60, 32, -23, -64, -1; /M: SY='K'; M= -61, -75, -62, -52, -19, -20, -60, -62, 73, -8, -58, -55, -70, -47, 62, -5, -21, 12, -74, -61; /M: SY='R'; M= -25, -73, -5, 36, -61, -8, -62, -13, -52, 41, -49, -13, -72, -53, 48, -7, -21, 7, -78, -63; /I: I=-19; MI=0; MD=-49; IM=0; DM=-49; /M: SY='R'; M= -6, -74, -68, -60, 0, -71, -62, 15, -21, -57, -55, -62, 27, 17, 50, 21, 0, 33, -70, 28; /M: SY='G'; M= 32, -73, -60, 14, -81, 83, -67, -81, -62, -79, -70, -52, -66, 8, -69, -47, 4, -73, -75, -74; /M: SY='Q'; M= 0, -73, -27, -27, -71, -22, 9, -31, 11, -40, 67, 22, -68, 69, 21, -6, 6, -16, -78, -61; /M: SY='Q'; M= -29, -76, 15, 28, -72, -68, 41, -12, 19, -19, -1, 26, 26, 49, -15, -21, -1, -6, -81, -63; /M: SY='Y'; M= -13, -77, -69, -8, 50, -76, 25, -56, -65, -20, -51, -69, -79, -62, -64, -64, -17, -60, -37, 114; /M: SY='L'; M= -67, -70, -85, -77, 8, -85, -70, -33, -78, 86, -31, -84, -84, -72, -75, -77, -64, -13, 45, -50; /M: SY='H'; M= -61, -76, -27, -16, 0, -71, 70, 4, 45, -65, -58, -50, -67, 53, 30, -7, 39, -63, -77, -55; /M: SY='Q'; M= 28, -72, 16, 14, -22, -23, 11, -67, 42, -69, -63, -51, -65, 47, -16, 16, 9, -3, -78, -63; /M: SY='T'; M= 36, -66, -71, -69, -58, -71, -74, 47, -67, 13, -46, -63, -69, -67, -72, -51, 66, 25, -79, -62; /M: SY='L'; M= -67, -70, -85, -78, -7, -87, -71, 34, -78, 84, -30, -82, -83, -72, -76, -77, -63, -36, -70, -52; /M: SY='G'; M= 6, -75, 1, -57, -73, 55, 51, -75, 31, -74, -65, -51, -68, -9, 29, 13, -59, -16, -76, -7; /M: SY='P'; M= 3, -83, 28, 21, -84, -67, -62, -76, 29, -79, -69, -59, 95, 21, -5, -57, -58, -75, -79, -74; /M: SY='V'; M= -47, 7, -78, -74, 41, -32, -75, 40, -73, 12, -45, -72, 37, -73, -76, 0, -24, 53, -72, -53; /M: SY='I'; M= -62, -72, -83, -78, -9, -86, 16, 65, -76, 49, -35, -77, -79, -73, -76, -72, -58, 50, -75, -54; /M: SY='M'; M= -28, -74, 34, 4, -69, -68, -57, -11, 48, 0, 49, 15, -68, 15, 27, 7, -19, -61, -79, -63; /M: SY='E'; M= -16, -24, 21, 40, -71, -3, -56, -16, 38, -70, -64, 28, -67, 25, 32, -55, -29, -13, -75, 11; /M: SY='I'; M= -61, -71, -82, -79, -49, -85, -79, 71, -76, 37, -36, -15, -78, -74, -78, -71, -56, 60, -78, -58; /M: SY='C'; M= -28, 57, -79, -76, 14, -78, -69, 51, -73, 18, 33, -72, -78, -71, -74, 6, -56, 37, -68, 36; /M: SY='Q'; M= 7, -74, 49, 52, -76, -67, -57, -25, -1, -38, -63, -9, -64, 54, -55, 3, 0, 4, -82, -67; /M: SY='S'; M= -55, -9, 44, 52, -76, -61, 6, -74, -52, -18, -67, 41, 6, -3, -59, 59, -50, -71, -86, -68; /M: SY='K'; M= -26, -74, 19, 30, -77, -6, 41, -73, 57, -74, -66, 19, -12, -46, 3, 22, -10, -15, -82, -65; /M: SY='K'; M= -40, -77, 47, 43, -77, -68, 19, -69, 53, -37, -65, -5, -10, 29, -22, 6, -56, 0, -82, -65; /I: I=-33; MI=0; MD=-84; IM=0; DM=-84; /M: SY='W'; M= -58, -74, 57, -51, -19, -60, 28, -41, -23, -73, -68, 56, -16, -6, -60, 53, -51, -45, 67, 22; /M: SY='C'; M= -65, 107, -84, -80, 62, -81, -73, 2, -77, 35, 33, -74, -85, -79, -78, -70, -62, -1, -69, -48; /M: SY='E'; M= -61, -80, 30, 101, -83, -73, 7, -84, 5, -77, -73, -7, -58, -36, -50, -56, -60, -77, -83, -71; /M: SY='I'; M= -57, -69, -75, -71, -53, -78, -74, 57, -70, 34, -41, -67, -73, -6, -73, 14, 36, 44, -78, -59; /M: SY='D'; M= -65, -78, 107, -11, -85, -62, 7, -84, -19, -83, -79, 35, -67, -52, -60, 3, -55, -81, -99, -69; /M: SY='P'; M= -10, -87, -66, -55, -85, -66, -69, -73, -7, -82, -70, -70, 121, -63, -70, -20, -57, -76, -79, -81; /M: SY='S'; M= -1, 9, -65, -64, -59, -67, 21, 12, -22, 2, 0, 12, -71, -20, 1, 38, 19, 32, -77, 12; /M: SY='K'; M= -62, -77, -15, -12, -73, -71, 6, -76, 84, -38, -63, -50, -66, 20, 51, -21, -7, -72, -73, -6; /I: I=-7; MD=-19; /M: SY='L'; M= -63, 48, -84, -79, -8, -85, -77, 32, -78, 53, 10, -78, -82, -75, -78, -27, -30, 45, -78, -58; D=-7; /I: I=-7; MD=-19; /M: SY='Y'; M= -84, -95, -22, -24, -2, -51, -68, -9, -31, -35, 17, -21, -94, -77, -24, -43, -25, -74, -66, 79; D=-7; /I: I=-7; MD=-19; /M: SY='Q'; M= -15, -96, -23, 9, -95, -87, -77, -32, 26, -43, -80, 0, -87, 44, -21, -25, -77, -31, -98, -86; D=-7; /I: I=-7; MD=-19; /M: SY='Q'; M= -13, -94, -17, -9, -89, -49, -73, -95, -2, -94, -86, 17, -88, 24, 14, 12, -32, -91, -93, 13; D=-7; /I: I=-7; MD=-19; /M: SY='W'; M= -91,-101, -21, -32, 47, -36, -92, 21, -90, -37, 3, -93, -99, -91, -26, -93, -89, -72, 75, -9; D=-7; /I: I=-7; MD=-19; /M: SY='I'; M= -80, -94, -87, -33, -83, -95, 21, 25, -81, -39, -72, -5, -94, -81, 0, 9, -16, 17,-105, -82; D=-7; /I: I=-7; MD=-19; /M: SY='P'; M= -38,-101, 10, -78,-106, 0, -82,-104, -77,-106, -96, 35, 36, -19, -1, -5, -80,-102,-109, -98; D=-7; /I: I=-7; MD=-19; /M: SY='Q'; M= -26, 10, -22, 17, -4, -95, 19, -96, 2, -46, -86, -79, -92, 30, -22, -56, -27, -93,-100, -82; D=-7; /I: I=-7; MI=0; MD=-19; IM=0; DM=-19; /M: SY='E'; M= -86, 25, -20, 31,-107, -5, -7, -36, -30,-102, -96, -82, -95, 4, -86, 2, -86, -99,-111, -98; D=-7; /I: I=-7; DM=-19; /M: SY='Q'; M= -22, -98, -32, -4, -99, -13, -83, -37, -28, -35, -85, -17, -91, 42, -80, 17, -33, -89,-103, -91; D=-7; /I: I=-7; DM=-19; /M: SY='A'; M= 32, -96, -21, 13, -22, -89, -90, -30, -29, -40, -84, -87, 2, -80, -26, -79, -82, -35,-100, -89; D=-7; /I: I=-7; DM=-19; /M: SY='Q'; M= -45, -97, -87, 4, -23, -98, 7, 4, -28, 5, 15, -86, -94, 15, -22, -32, -82, -15, -97, -78; D=-7; /I: I=-7; DM=-19; /M: SY='Q'; M= -50, -97, 13, 11, 0, -35, -73, -94, -69, -90, -85, 10, -89, 42, 3, -18, -21, -92, -91, 6; D=-7; /I: I=-7; DM=-19; /M: SY='H'; M= -52, -97, -4, -5, -21, -91, 51, -84, -30, -12, -76, -17, -13, 4, -3, -26, -46, -35, -96, -6; D=-7; /I: I=-7; DM=-19; /M: SY='P'; M= -21, -99, -20, 13, -98, -49, -79, -89, -5, -61, -83, -31, 63, 29, -8, -75, -77, -39, -97, -90; D=-7; /I: I=-7; DM=-19; /M: SY='E'; M= -13, -79, -51, 61, -81, -71, -62, -76, 32, -77, -70, 2, 29, -48, 28, 10, -4, -19, -83, -73; D=-7; /I: I=-7; DM=-19; /M: SY='V'; M= -28, -71, -1, 27, -65, -35, -69, -15, 9, -12, -54, -61, 27, -59, -63, 1, 26, 59, -83, -66; /M: SY='Q'; M= 23, -73, -17, 1, -79, 16, -59, -76, 37, -76, -66, 8, 14, 41, 19, 29, -6, -70, -78, -69; /M: SY='E'; M= -6, -73, -3, 60, -78, -37, -54, -75, 1, -75, -68, 58, -34, 19, 13, 31, -15, -33, -82, -69; /M: SY='M'; M= -16, -72, 28, 3, -1, -67, -57, -3, 26, -23, 49, 23, -69, -53, 4, 29, -15, -12, -72, 20; /M: SY='L'; M= -32, -71, -78, -72, 28, -81, 20, 22, -66, 55, -39, -73, -80, -67, 18, -30, -60, 33, -68, 9; /M: SY='E'; M= 23, -76, 26, 73, -76, -69, -59, -4, -3, -67, -64, -7, 9, 11, -19, -55, -57, 6, -81, -70; /M: SY='E'; M= -7, -73, 31, 46, -74, -15, -58, -27, 19, -17, -64, 13, -9, 9, -4, 21, 24, -65, -81, -68; /M: SY='N'; M= -28, -70, -47, -56, -73, -58, 46, -68, -47, -72, -3, 92, -71, 8, 33, 25, -3, -8, -88, -64; /M: SY='Q'; M= -25, -5, -69, -3, -12, -77, -63, 14, -15, 45, 9, -67, -74, 59, -6, -24, -59, 20, -71, -6; /M: SY='R'; M= 29, -74, 5, 36, -77, 8, -9, -75, 10, -71, 19, -13, -66, 20, 50, 11, -28, -68, -78, -66; /M: SY='N'; M= -38, 27, -49, -8, -72, -62, 12, -70, 42, -1, -61, 79, -70, 17, 9, 11, -12, -69, -83, -65; /M: SY='L'; M= -67, 10, -85, -77, 8, -85, -68, -34, -78, 87, 12, -82, -84, -71, -75, -77, -63, -41, -70, -51; /M: SY='R'; M= -64, -76, -70, -26, -54, -79, 38, 1, -18, 25, -7, -65, -76, -19, 66, -65, -18, 24, 51, 28; /M: SY='Q'; M= 21, -72, 22, -5, -71, 2, 25, -68, 21, -36, 20, 22, -67, 41, -10, 19, -21, -32, -77, 2; /M: SY='Y'; M= -6, 25, -75, -72, 19, -75, 42, 24, -69, 12, 42, -68, -77, -65, -69, -18, -5, -2, 50, 72; /M: SY='C'; M= -13, 91, -77, -74, -17, -77, -76, -1, -71, 4, 25, -68, -77, -73, -75, -59, 42, 58, -84, -63; /M: SY='E'; M= -59, -77, 57, 62, -82, -14, -54, -78, 3, -77, -70, 24, -63, 50, -25, 10, 0, -47, -84, -69; /M: SY='K'; M= -25, -75, 0, 34, -73, -41, -57, -66, 57, -23, 37, -7, -28, 17, 35, -3, -17, -19, -77, -65; /M: SY='F'; M= 0, -69, -84, -78, 86, -80, -72, 15, -76, 31, -2, -77, -81, -78, -75, -69, -61, 36, -58, -37; /M: SY='W'; M= -17, -71, -85, -78, 66, -81, -73, 12, -76, 55, -40, -79, -81, -75, -75, -71, -29, 17, 77, -40; /M: SY='E'; M= -57, 25, 39, 54, -72, -3, 32, -71, 7, -38, -66, 4, -65, -16, -56, 27, 12, -19, -82, -7; /M: SY='A'; M= 52, -9, -62, -59, -67, -5, -60, -10, 26, -65, 20, 25, -68, -54, 15, 19, -6, -31, -73, 14; /M: SY='I'; M= -65, -75, -85, -81, -45, -88, -77, 91, -78, 36, -35, -78, -77, -74, -79, -74, -59, 12, -70, 13; /M: SY='T'; M= -57, -14, -68, -63, 5, -72, -66, 44, -5, -8, -49, -59, -70, 32, -63, 31, 49, 19, -71, 17; /M: SY='S'; M= -27, -73, -16, -19, -74, -21, 15, -27, 39, -34, 8, 38, -67, 47, 18, 48, -18, -67, -79, -63; /M: SY='S'; M= 9, -65, -53, -56, -75, -51, -57, -72, -6, -77, -69, 50, -14, -50, -59, 88, 7, -66, -83, -68; /M: SY='S'; M= -5, -69, -71, -69, -53, -28, 13, 17, -67, 18, -49, -63, -72, -63, -69, 47, 9, 42, 47, 22; /M: SY='N'; M= -16, 25, 47, 10, -69, -26, 37, -67, -30, -70, -14, 49, -13, -53, -14, 33, -19, 0, -82, 14; /I: I=-31; MI=0; MD=-79; IM=0; DM=-79; /M: SY='C'; M= -38, 38, 18, 21, -66, -69, -9, -19, -18, -7, 30, 26, -70, 34, 26, 3, 7, -14, 23, -9; /M: SY='C'; M= -68, 83, -85, -81, 72, -84, -73, 47, -78, 39, 5, -76, -83, -79, -78, -73, -63, -41, -63, -43; /M: SY='P'; M= -66, -92, -67, -55, -86, -68, -70, -74, -63, -84, -70, -73, 128, -66, -75, -64, -59, -79, -79, -83; /M: SY='Y'; M= 3, -77, 14, -58, -54, -38, 43, -7, -16, -47, -58, -59, 53, -58, 11, -1, 8, -12, -63, 70; /M: SY='E'; M= -1, -73, -52, 47, -74, 32, 22, -39, -55, -39, -62, 22, 4, 36, -61, 17, -13, 11, -80, -67; /M: SY='L'; M= -65, -71, -85, -78, -45, -85, -71, 55, -76, 67, 65, -79, -79, -70, -75, -75, -61, 5, -73, -54; /M: SY='R'; M= -64, 65, -62, -55, -22, -24, -57, -77, 35, -73, -64, 13, -75, -46, 94, -59, -62, -35, -77, -64; /M: SY='W'; M= -10, -80, 28, 4, -8, -69, -59, -41, -62, 3, -58, 1, -74, 5, -65, -1, -40, -66, 119, 69; /M: SY='I'; M= -27, -9, -80, -76, -52, -83, -80, 78, -74, 13, -39, -73, -75, -11, -76, -66, 12, 50, -78, -59; /M: SY='C'; M= 24, 100, -81, -77, 70, -74, -72, -18, -74, 12, -51, -72, -82, -77, -76, -64, -60, 8, -64, 3; /M: SY='K'; M= 10, -74, -18, -50, -15, -24, 37, -74, 61, -71, -63, -51, -67, 25, 38, 20, -2, -69, -70, 21; /M: SY='Q'; M= -35, 49, 27, -50, -71, -46, -58, -25, -5, -35, -60, 10, -69, 75, -55, 34, 18, 7, -80, -10; /M: SY='W'; M= -66, -74, -84, -79, 19, -20, -74, 55, -76, 60, 29, -78, -79, -72, -76, -73, -22, -37, 73, -48; /M: SY='Y'; M= -33, -78, -65, -56, 48, -73, -9, -68, 32, -62, -58, -59, -74, 36, 67, -11, -62, -67, -54, 69; /M: SY='Q'; M= -29, 66, 2, 29, -76, -67, -55, -72, 23, -15, -62, 47, -69, 67, 9, -18, -17, -70, -81, -67; /M: SY='S'; M= 15, 46, -64, -32, -64, -65, -62, -2, 8, -33, 12, -56, -69, 15, 25, 47, 16, 2, -75, 11; /M: SY='A'; M= 51, 49, -76, -70, -56, -69, -73, -11, -71, 46, -44, -71, -75, -68, -73, -57, 2, 38, -78, -63; /M: SY='Q'; M= 22, 30, -56, 30, -69, -17, 22, -70, -11, -31, -61, -11, -68, 58, 21, 23, -28, -37, -73, 20; /M: SY='E'; M= -19, 30, 3, 59, -76, -71, 33, -29, 27, -37, -62, -33, -66, 46, 38, -32, -22, -33, -80, -64; /M: SY='R'; M= -62, -75, -60, -55, -62, -72, 20, -2, 54, -22, -56, 24, -71, -16, 59, -8, -22, 15, -72, 24; /M: SY='F'; M= -33, 32, -17, -33, 92, 10, -2, -54, -70, -16, -55, 14, -79, -73, -72, -28, -62, -5, 37, -5; /M: SY='P'; M= -63, -83, 32, -52, -77, -36, -64, 4, -38, -39, -64, -59, 95, -6, 37, 6, -17, -67, -80, -72; /M: SY='D'; M= -19, -76, 66, 41, -78, -25, 22, -75, -4, -22, -67, 24, 3, 23, -20, 8, -13, -73, -86, -67; /I: I=-42; MI=0; MD=-106; IM=0; DM=-106; /M: SY='D'; M= 21, -73, 44, 41, -71, -27, 36, -26, 19, -45, 6, 25, -66, -50, -55, -4, -4, -17, -81, -12; /M: SY='Q'; M= 7, -72, -16, 5, -68, -31, 18, 14, -57, -4, -10, -40, 22, 49, -30, 34, 22, -8, -79, -63; /M: SY='D'; M= 16, -74, 73, 12, -72, -3, 38, 1, 5, -37, -64, -48, -67, -54, -60, -6, 5, -30, -83, -12; /M: SY='E'; M= -57, -75, -7, 56, -68, -36, -63, 33, -56, -57, 9, -59, 15, 42, -61, 18, -9, 32, -80, -65; /I: I=-16; MD=-41; /M: SY='R'; M= -68, -82, -62, 33, -73, -80, -63, 10, 1, -2, -60, 5, -75, 30, 59, -64, 1, -10, -83, -68; D=-16; /I: I=-16; MD=-41; /M: SY='Y'; M= -32, -85, -79, -28, -58, -87, 21, 15, -68, 21, -56, -76, -86, 5, 22, -28, -18, -5, -74, 50; D=-16; /I: I=-16; MD=-41; /M: SY='K'; M= -80, 4, -87, -81, -7, -91, -83, -79, 22, 12, -74, -80, -13, -77, -10, 19, -6, -79, -91, -10; D=-16; /I: I=-16; MI=0; MD=-41; IM=0; DM=-41; /M: SY='A'; M= 67, 8, -74, -68, -60, -28, -73, 3, -69, 31, -47, -69, -73, -66, -72, -26, -54, 35, -77, -64; /M: SY='V'; M= -29, 36, -84, -79, -52, -84, -81, 66, -76, 0, 28, -76, -77, -75, -78, -69, -55, 70, -81, -60; /M: SY='S'; M= -11, 52, -61, -64, -76, 59, -66, -78, 0, -77, -70, -49, -67, -57, -64, 68, 15, -70, -80, -71; /M: SY='S'; M= 19, -69, 28, -57, -71, 43, -59, -75, -11, -76, -69, 28, -67, -55, -62, 58, 2, -69, -76, 18; /M: SY='F'; M= -15, -70, -1, -72, 90, -74, -66, -4, -72, 21, 32, -68, -78, -72, -72, 21, -59, -10, -57, -36; /M: SY='I'; M= -62, -71, -85, -79, -9, -86, -76, 60, -77, 52, 28, -79, -79, -73, -77, -73, -58, 51, -74, -54; /M: SY='F'; M= -70, 13, -83, -80, 98, -82, -61, -18, -75, -10, 3, -76, -84, -79, -73, -71, -64, 16, -44, 67; /M: SY='L'; M= -64, -71, -75, -73, -40, -77, -61, -40, -71, 70, 6, 2, -80, -66, -70, -3, -6, -9, 45, 55; /M: SY='R'; M= -3, -78, -61, -53, -74, -72, 22, -74, 2, -72, -62, 13, -73, -44, 102, -57, -26, -15, -78, -62; /I: I=-45; MI=0; MD=-115; IM=0; DM=-115; /M: SY='F'; M= -74, -72, -84, -81, 109, -83, -62, -47, -76, 15, -47, -77, -85, -81, -73, -73, -67, -53, -41, 58; /M: SY='F'; M= -66, -72, -86, -81, 72, -85, -73, 59, -77, 35, 33, -78, -80, -77, -77, -73, -61, 23, -61, -41; /M: SY='C'; M= 30, 111, -60, -65, -75, 0, -64, -75, -62, -74, -68, 57, -75, -8, -68, 33, -52, -66, -88, -74; /M: SY='P'; M= -32, -86, -65, -5, -80, -68, -69, -65, -62, -38, -66, -71, 117, -64, -73, -10, -57, -5, -80, -79; /M: SY='A'; M= 91, -63, -70, -62, -67, -53, -69, -9, -64, -61, -57, -64, -68, -61, -68, -44, -53, 2, -72, 11; /M: SY='I'; M= -64, -75, -86, -82, -48, -89, -81, 94, -78, 29, 11, -77, -76, -74, -80, -74, -59, 14, -74, -56; /M: SY='V'; M= -34, -69, -82, -73, -50, -83, -74, 20, -73, 47, 35, -77, -79, 5, -73, -68, -56, 72, -79, -58; /M: SY='S'; M= 21, -64, -53, -58, -73, -31, -58, -67, -56, -73, -66, 61, -66, -52, -62, 80, 20, -15, -85, -68; /M: SY='P'; M= -19, -90, -67, -55, -85, -67, -69, -74, -60, -83, -70, -72, 123, -64, -5, -62, -59, -77, -79, -82; /M: SY='D'; M= -60, -78, 63, 47, -75, -66, 15, -80, 41, -76, -69, -6, -64, 34, -9, 23, -56, -76, -78, 13; /M: SY='L'; M= 18, -70, -62, 10, -54, -26, -58, -52, 0, 48, 11, 25, -72, 13, -60, -6, -4, -54, -70, 28; /M: SY='F'; M= -16, -72, -76, -8, 102, -77, -60, -52, -71, -29, -52, -72, -81, -73, -70, -6, -63, -28, -43, 64; /M: SY='G'; M= -58, -77, 50, 0, -76, 61, 38, -81, 16, -78, 1, 46, -68, -4, -58, -52, -60, -79, -80, -7; /M: SY='I'; M= -65, -74, -84, -80, -42, -87, -72, 75, -77, 58, -33, -79, -79, -72, -77, -74, -60, 6, -67, 29; /M: SY='I'; M= -6, -71, -76, -69, -54, -79, -71, 51, -8, 29, 26, -69, -74, -64, 30, -64, 7, 41, -77, -59; /M: SY='D'; M= -28, -76, 83, -10, -80, -26, -58, -33, -3, -58, -71, -45, 37, 9, -60, 38, 7, -71, -88, -69; /I: I=-36; MI=0; MD=-90; IM=0; DM=-90; /M: SY='D'; M= -57, -76, 40, 27, -74, 32, 36, -27, 11, -68, -63, -9, -67, 16, 7, 8, -57, 27, -83, -65; /M: SY='H'; M= 0, 6, -52, 2, -66, -27, 80, -74, -3, -47, -61, 51, -69, 31, 15, 18, -21, -71, -76, 32; /M: SY='P'; M= 4, -77, -69, -62, -66, -71, 24, 28, -65, 4, -52, 1, 88, -9, -71, -61, -16, 20, -80, -67; /M: SY='D'; M= -7, -72, 64, -50, -74, 4, 6, -8, -58, -20, -64, 14, 7, 10, -64, 43, 23, -64, -85, -66; /I: I=-45; MD=-115; /M: SY='P'; M= 24, -78, 4, 15, -79, -29, -68, -10, -25, -42, -68, 7, 65, -61, -69, 2, 30, -65, -85, -76; D=-45; /I: I=-45; MI=-115; IM=-115; DM=-115; /M: SY='Q'; M= -28, -76, -2, 0, -72, -23, 1, 13, 8, -25, -58, 3, -68, 60, 54, -3, 24, -61, -78, -63; /M: SY='T'; M= 19, -69, -20, -22, -68, -66, -64, -4, -8, -58, 19, 16, 16, 37, -61, -16, 57, 31, -82, -65; /M: SY='R'; M= 34, -71, -56, -2, -75, -61, -56, -40, 0, -72, -64, 35, -68, 17, 64, 36, -8, -37, -79, -66; /M: SY='R'; M= -66, -82, -60, -48, -76, -74, 55, -82, 47, -75, -63, -53, -72, 14, 98, -59, -64, -77, -77, -59; /M: SY='N'; M= -56, -67, -49, -59, 3, -10, 6, -68, -5, -71, -65, 82, -17, -55, -59, 18, 71, -65, -84, -63; /I: I=-38; MI=0; MD=-97; IM=0; DM=-97; /M: SY='L'; M= -67, -69, -85, -77, 9, -86, -69, 2, -78, 88, -29, -83, -84, -72, -75, -77, -63, -39, -69, -51; /M: SY='T'; M= -8, -69, -1, -63, -60, 6, -65, 23, -6, -1, 26, 2, -69, -61, -5, -52, 61, 9, -76, 7; /M: SY='L'; M= -29, -70, -67, -62, -51, -72, -60, -4, -63, 61, -41, 11, -74, 54, -64, 11, 20, -48, -71, 11; /M: SY='I'; M= -62, -72, -85, -80, -47, -87, -78, 76, -77, 45, 28, -78, -78, -73, -78, -73, -58, 42, -75, -56; /M: SY='A'; M= 74, -64, -65, -61, -68, -7, -64, -62, -62, -65, 22, -57, -67, -57, -66, 53, -48, -13, -73, 9; /M: SY='K'; M= -62, -77, -57, -44, -76, -69, -57, -75, 98, -72, 30, -50, -65, 16, 29, -11, -57, -72, -73, -64; /M: SY='V'; M= -6, -67, -75, -72, -54, -76, -75, 44, -70, 19, 8, -68, -73, -69, -73, 9, 35, 60, -80, -60; /M: SY='L'; M= -64, -71, -84, -78, -45, -86, -73, 58, -77, 68, 25, -79, -79, -72, -76, -74, -31, 19, -74, -55; /M: SY='Q'; M= -14, -80, -57, -38, -80, -67, -50, -68, -44, 1, -54, -52, -68, 122, -44, -9, -60, -70, -72, -61; /M: SY='N'; M= -26, -70, -48, -8, -73, -59, 48, -37, -49, -69, 30, 78, -68, 37, 11, 33, 28, -67, -86, -62; /M: SY='L'; M= 12, -70, -83, -76, -9, -81, -74, 52, -76, 65, -34, -78, -79, -71, -76, -69, -59, 16, -72, -55; /M: SY='A'; M= 71, -65, -68, -65, 54, 26, -68, -65, -65, -63, -62, -60, -69, -63, -69, 30, -54, -58, -67, -55; /M: SY='N'; M= -27, -67, -45, -5, -68, -56, -51, -64, -53, 8, 6, 97, -70, -52, -60, 43, 6, -65, -87, -67; /M: SY='M'; M= -63, 16, -68, -68, 32, 20, 25, 13, -59, 21, 41, 32, -75, -18, 27, -61, -1, -54, 39, -52; /M: SY='K'; M= 7, -71, 17, 21, -74, 17, -63, -62, 46, -68, -63, -52, -65, -5, -18, 23, 12, 25, -80, -68; /M: SY='E'; M= -28, -7, -55, 41, 20, -68, -59, -62, 16, 4, 4, 5, 25, 31, -27, 25, 13, -30, -74, -60; /M: SY='F'; M= -65, 21, -26, 23, 97, -36, -62, -59, -65, -36, -57, 5, -10, 8, -67, 16, -60, -61, -55, -35; /I: I=-28; MD=-70; /M: SY='G'; M= -17, -78, -6, 21, -23, 35, -69, -33, -22, -19, -69, -59, -72, 9, -34, 32, 21, -44, -83, -72; D=-28; /I: I=-28; MD=-70; /M: SY='S'; M= -25, -84, -67, -3, -27, 43, -72, -89, -37, -89, -81, 15, 27, -65, -11, 45, -63, -84, -88, -80; D=-28; /I: I=-28; MI=0; MD=-70; IM=0; DM=-70; /M: SY='K'; M= -62, -79, 19, -12, -82, -68, -58, -81, 83, -81, -70, 5, 14, 25, -10, 18, -56, -77, -79, -69; D=-28; /I: I=-28; DM=-70; /M: SY='E'; M= -60, -78, 27, 92, -78, -71, -55, -78, -6, -29, -70, 13, -8, -40, -54, -6, -18, -74, 24, -69; /M: SY='E'; M= 2, -77, 11, 48, -76, 7, 5, -31, -17, -17, -64, 15, 43, 7, 17, 2, -29, -68, -80, -68; /M: SY='W'; M= -35, -78, -73, -70, 66, -76, 83, -25, -68, -28, -53, -22, -78, -66, -66, -66, -18, -4, 97, 66; /M: SY='M'; M= -64, -71, -22, -66, 17, -78, -59, -41, 9, 50, 105, -68, -75, 7, -15, -69, -31, -47, -70, -50; /M: SY='E'; M= 2, 37, 1, 38, -71, -25, -61, -23, 5, -23, 1, -3, -68, -3, 30, 26, -19, 11, -81, -66; /M: SY='P'; M= -46, 3, -27, -3, 50, -8, -65, -24, -24, -63, 18, -21, 78, -62, -20, 29, -25, -28, -70, -56; /M: SY='M'; M= -65, -70, -78, -12, 44, -81, -64, -12, -30, 59, 85, -75, -77, -13, -68, -72, -62, -1, -67, -47; /M: SY='N'; M= -60, -70, -44, -23, -4, -22, 10, -70, -21, -16, -63, 101, -72, 19, -56, 19, -50, -71, -79, 11; /M: SY='E'; M= -61, -79, 44, 52, -79, -29, -56, -73, 30, -27, -66, 13, 41, 46, -22, -24, -37, -31, -81, -69; /M: SY='F'; M= -70, 36, -81, -77, 94, -79, -60, -52, -39, -45, 54, -72, -81, -74, -70, -68, 2, -56, 61, 65; /M: SY='I'; M= -16, -72, -1, -72, 23, -82, -72, 50, -69, 50, -39, -73, -78, -70, 3, -69, -59, 34, -72, -53; /M: SY='K'; M= -60, -10, 0, 40, -72, -16, -24, -12, 47, -16, 19, 44, -66, 4, 3, 0, 2, -64, -80, -66; /M: SY='E'; M= -14, -73, 0, 57, -76, -20, 4, -70, 0, -46, -64, -51, -63, 48, -26, 45, 24, -18, -81, -66; /M: SY='H'; M= -58, 63, -51, 37, -70, -24, 70, -12, -18, -69, -63, 42, -68, -3, -18, 27, 24, -66, -84, -6; /I: I=-42; MI=0; MD=-106; IM=0; DM=-106; /M: SY='W'; M= -14, -72, -65, -22, 15, 3, 28, -19, 38, -59, 23, -58, -69, -57, -56, 20, 24, 18, 62, 21; /M: SY='D'; M= 10, -76, 52, 42, -79, -7, 27, -41, -53, -39, -66, -10, 37, 38, -60, 12, -11, -70, -83, -68; /M: SY='D'; M= 31, -73, 44, 4, -73, -48, 24, -24, 30, -47, 30, -2, -67, 0, 32, -28, -4, -30, -81, -64; /M: SY='M'; M= -13, -69, -82, -76, 42, -79, -69, 36, -72, -4, 93, -73, -75, -70, -72, -66, -7, 50, -70, -49; /M: SY='K'; M= -32, -76, 7, -50, 2, -72, 6, -20, 59, -6, 17, -55, -70, 34, 51, -25, -60, -15, -71, -5; /M: SY='D'; M= 8, -19, 60, -46, -75, -62, 19, -73, 18, -28, 7, 36, -69, 23, 34, 25, -54, -70, -84, -64; /M: SY='F'; M= -69, -73, -83, -80, 94, -83, -62, 16, -75, 4, 19, -76, -83, -77, -73, -72, -63, 15, -46, 63; /M: SY='L'; M= -67, -70, -85, -79, 49, -86, -71, 36, -78, 73, -33, -81, -82, -74, -76, -76, -62, -1, -65, -46; /M: SY='D'; M= -31, -76, 61, 23, -64, -69, 6, -6, -31, 0, -15, 5, 2, 25, -18, 4, -28, -5, -77, 24; /M: SY='E'; M= -61, -78, 20, 61, -76, -12, -55, -39, 25, -19, -63, 20, -65, 51, 26, -55, -11, -30, -79, -67; /M: SY='I'; M= 18, -71, -76, -71, -53, -13, -71, 59, -26, 43, 7, -12, -75, 5, -70, -63, -58, 12, -75, -59; /I: E1=0; IE=-380; DE=-380;» more |
Numerical results [info]
| Total number of hits | 57 in 57 different sequences |
| Number of true positive hits | 57 in 57 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 0 |
| Number of false negative sequences | 0 |
| Number of 'partial' sequences | 0 |
| Precision (true positives / (true positives + false positives)) | 100.00 % |
| Recall (true positives / (true positives + false negatives)) | 100.00 % |
Comments [info]
| Taxonomic range [info] | Eukaryotes |
| Maximum number of repetitions [info] | 1 |
| Matrix type [info] | protein_domain |
| Scaling database [info] | reversed |
| Author [info] | CJA_Sigrist |
| Feature key [info] | DOMAIN |
| Feature description [info] | Ras-GAP |
| Version [info] | 8 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
57 sequences
BUD2_CANAL (Q5A506), BUD2_YEAST (P33314), DAB2P_HUMAN (Q5VWQ8), DAB2P_MOUSE (Q3UHC7), DAB2P_RAT (Q6P730), GAP1_CAEEL (Q22720), GAP1_DROME (P48423), GAP1_SCHPO (P33277), GAP2_CAEEL (Q8MLZ5), GAP2_DROME (Q8T498), GAPA_DICDI (O00899), GAPD1_BOVIN (A5D794), GAPD1_HUMAN (Q14C86), GAPD1_MOUSE (Q6PAR5), GAPD1_XENLA (A2RV61), IQG1_CANAL (Q5AH02), IQG1_SCHPO (O14188), IQG1_YEAST (Q12280), IQGA1_HUMAN (P46940), IQGA1_MOUSE (Q9JKF1), IQGA2_HUMAN (Q13576), IQGA2_MOUSE (Q3UQ44), IQGA3_HUMAN (Q86VI3), IRA1_YEAST (P18963), IRA2_YEAST (P19158), NF1_HUMAN (P21359), NF1_MOUSE (Q04690), NF1_RAT (P97526), NFAA_DICDI (Q55AR6), NGAP_DICDI (Q54Y08), NGAP_HUMAN (Q9UJF2), RAS4B_HUMAN (C9J798), RASA1_BOVIN (P09851), RASA1_HUMAN (P20936), RASA1_RAT (P50904), RASA2_HUMAN (Q15283), RASA2_MOUSE (P58069), RASA2_RAT (Q63713), RASA3_BOVIN (Q28013), RASA3_HUMAN (Q14644), RASA3_MOUSE (Q60790), RASA3_RAT (Q9QYJ2), RASL1_HUMAN (O95294), RASL1_MOUSE (Q9Z268), RASL2_HUMAN (O43374), RASL2_MOUSE (Q6PFQ7), RASL3_BOVIN (A6QQ91), RASL3_HUMAN (Q86YV0), RASL3_MOUSE (Q8C2K5), RGAA_DICDI (Q54K32), RME6_CAEBR (A8WVM4), RME6_CAEEL (Q9GYH7), RME6_DROME (Q9VZ08), RME6_DROPS (Q29HW3), SYGP1_HUMAN (Q96PV0), SYGP1_MOUSE (F6SEU4), SYGP1_RAT (Q9QUH6)» more
|
| PDB [Detailed view] |
28 PDB
pdb_00001nf1; pdb_00001wer; pdb_00001wq1; pdb_00003bxj; pdb_00003fay; pdb_00005cjp; pdb_00006ob2; pdb_00006ob3; pdb_00006v65; pdb_00006v6f; pdb_00007moc; pdb_00007mp5; pdb_00007mp6; pdb_00007pgp; pdb_00007pgq; pdb_00007pgr; pdb_00007pgs; pdb_00007pgt; pdb_00007pgu; pdb_00007r03; pdb_00007r04; pdb_00008bos; pdb_00008e20; pdb_00008edl; pdb_00008edm; pdb_00008edn; pdb_00008edo; pdb_00009bz4 » more |