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annotation rule: PRU00245

General rule information [?]

Accession PRU00245
Dates 12-DEC-2003 (Created)
16-DEC-2016 (Last updated, Version 12)
Data class Domain
Predictors PROSITE; PS50807; GCM
Name GCM domain
Function The GCM motif has been shown to be a DNA binding domain that recognizes preferentially the nonpalindromic octamer 5'-ATGCGGGT-3'.

Propagated annotation [?]


Comments [?]

Subcellular location Nucleus.

Gene Ontology [?]

GO:0007275; Biological process: multicellular organism development.
GO:0003677; Molecular function: DNA binding.
GO:0005634; Cellular component: nucleus.
GO:0006355; Biological process: regulation of transcription, DNA-templated.
GO:0006351; Biological process: transcription, DNA-templated.
case <FTGroup:1>
GO:0046872; Molecular function: metal ion binding.
GO:0008270; Molecular function: zinc ion binding.
end case


Keywords [?]

case <FTGroup:1>
end case


Features [?]

From: PS50807
Key     From     To       Description   Tag   Condition   FTGroup
DNA_BIND     from     to       GCM #        
METAL     63     63       Zinc #1     C   1
METAL     69     69       Zinc #2     C   2
METAL     73     73       Zinc #2     C   2
METAL     100     100       Zinc #2     C   2
METAL     105     105       Zinc #2     C   2
METAL     114     114       Zinc #1     C   1
METAL     141     141       Zinc #1     H   1
METAL     143     143       Zinc #1     H   1

Additional information [?]

Size range 156-160 amino acids
Related rules None
Repeats 1
Topology Cytoplasmic
Example Q9NP62 (GCM1_HUMAN)
Scope
Eukaryota

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



UniProtKB rule member sequences [?]