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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00245


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00245
General rule information [?]

Accession PRU00245
Dates 12-DEC-2003 (Created)
19-NOV-2022 (Last updated, Version 17)
Data class Domain;
Predictors PROSITE; PS50807; GCM
Name GCM domain
Function The GCM motif has been shown to be a DNA binding domain that recognizes preferentially the nonpalindromic octamer 5'-ATGCGGGT-3'.
Scope(s) Eukaryota
Example(s) Q9NP62;

Propagated annotation [?]

Comments [?]

SUBCELLULAR LOCATIONNucleus.

Keywords [?]

Developmental protein
DNA-binding
Nucleus
Transcription
Transcription regulation
case <FTGroup:1>
Metal-binding
Zinc
end case

Gene Ontology [?]

GO:0007275; Biological process:multicellular organism development
GO:0003677; Molecular function:DNA binding
GO:0005634; Cellular component:nucleus
GO:0006355; Biological process:regulation of DNA-templated transcription
GO:0006351; Biological process:DNA-templated transcription
case <FTGroup:1>
GO:0046872; Molecular function:metal ion binding
GO:0008270; Molecular function:zinc ion binding
end case

Features [?]

From: PS50807
Key From To Description Tag Condition FTGroup
DNA_BIND from to /note="GCM #"

Additional information [?]

Size range 156-160 amino acids
Related rules None
Fusion None
Repeats 1
Topology Cytoplasmic

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]