General rule information
[?]
Accession |
PRU00274 |
Dates |
12-DEC-2003 (Created) 21-NOV-2019 (Last updated, Version 19) |
Predictors |
PROSITE; PS50240; TRYPSIN_DOM
|
Name |
Serine proteases, trypsin domain |
Function |
Cleaves preferentially: Arg-|-Xaa, Lys-|-Xaa |
Propagated annotation
[?]
case <FTGroup:1>
end case
Similarity |
Belongs to the peptidase S1 family. |
case <FTGroup:1>
else
end case
case <FTGroup:1>
GO:0016787; Molecular function: hydrolase activity.
GO:0008233; Molecular function: peptidase activity.
GO:0004252; Molecular function: serine-type endopeptidase activity.
end case
case <FTTag:disulf>
end case
From: PS50240 |
Key
|
|
From
|
|
To
|
|
Description
|
|
Tag
|
|
Condition
|
|
FTGroup
|
DOMAIN
|
|
from
|
|
to
|
|
Peptidase S1 #
|
|
|
|
|
|
|
ACT_SITE
|
|
42
|
|
42
|
|
Charge relay system
|
|
|
|
H
|
|
1
|
ACT_SITE
|
|
91
|
|
91
|
|
Charge relay system
|
|
|
|
D
|
|
1
|
ACT_SITE
|
|
186
|
|
186
|
|
Charge relay system
|
|
|
|
S
|
|
1
|
DISULFID
|
|
27
|
|
43
|
|
|
|
disulf
|
|
C-x*-C
|
|
|
DISULFID
|
|
125
|
|
192
|
|
|
|
disulf
|
|
C-x*-C
|
|
|
DISULFID
|
|
156
|
|
171
|
|
|
|
disulf
|
|
C-x*-C
|
|
|
DISULFID
|
|
182
|
|
210
|
|
|
|
disulf
|
|
C-x*-C
|
|
|
Additional information
[?]
Size range |
150-286 amino acids |
Related rules |
None |
Repeats |
1-2 |
Topology |
Undefined |
Example |
Q9BYE2 (TMPSD_HUMAN) |
Scope |
Eukaryota
Bacteria |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and
distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives
(CC BY-NC-ND 4.0) License, see
prosite_license.html.
UniProtKB rule member sequences
[?]