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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00274


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00274
General rule information [?]

Accession PRU00274
Dates 12-DEC-2003 (Created)
21-NOV-2019 (Last updated, Version 20)
Data class Domain;
Predictors PROSITE; PS50240; TRYPSIN_DOM
Name Serine proteases, trypsin domain
Function Cleaves preferentially: Arg-|-Xaa, Lys-|-Xaa
Scope(s) Eukaryota
Bacteria
Example(s) Q9BYE2;

Propagated annotation [?]

Identifier, protein and gene names [?]

case <FTGroup:1>
Protein name + RecName: EC=3.4.21.-;
end case

Comments [?]

SIMILARITYBelongs to the peptidase S1 family.
case <FTGroup:1>
case <FTGroup:1>

Keywords [?]

Hydrolase
Protease
Serine protease
end case
case <FTTag:disulf>
Disulfide bond
end case

Gene Ontology [?]

case <FTGroup:1>
case <FTGroup:1>
GO:0016787; Molecular function:hydrolase activity
GO:0008233; Molecular function:peptidase activity
GO:0004252; Molecular function:serine-type endopeptidase activity

Cross-references [?]

PROSITE PS00134; TRYPSIN_HIS; 1;
PROSITE PS00135; TRYPSIN_SER; 1;
PROSITE PS00134; TRYPSIN_HIS; 0-1;
PROSITE PS00135; TRYPSIN_SER; 0-1;

Features [?]

From: PS50240
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Peptidase S1 #"
ACT_SITE 42 42 /note="Charge relay system" H 1
ACT_SITE 91 91 /note="Charge relay system" D 1
ACT_SITE 186 186 /note="Charge relay system" S 1
DISULFID 27 43 disulf C-x*-C
DISULFID 125 192 disulf C-x*-C
DISULFID 156 171 disulf C-x*-C
DISULFID 182 210 disulf C-x*-C

Additional information [?]

Size range 150-286 amino acids
Related rules None
Fusion None
Repeats 1-2
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]