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ProRule PRU00274


General rule information [?]

Accession PRU00274
Dates 12-DEC-2003 (Created)
21-NOV-2019 (Last updated, Version 19)
Data class Domain;
Predictors PROSITE; PS50240; TRYPSIN_DOM
Name Serine proteases, trypsin domain
Function Cleaves preferentially: Arg-|-Xaa, Lys-|-Xaa
Scope(s) Eukaryota
Bacteria
Example(s) Q9BYE2 (TMPSD_HUMAN);

Propagated annotation [?]

Identifier, protein and gene names [?]

case <FTGroup:1>
Protein name + RecName: EC=3.4.21.-;
end case

Comments [?]

SIMILARITYBelongs to the peptidase S1 family.
case <FTGroup:1>
case <FTGroup:1>

Keywords [?]

Hydrolase
Protease
Serine protease
end case
case <FTTag:disulf>
Disulfide bond
end case

Gene Ontology [?]

case <FTGroup:1>
case <FTGroup:1>
GO:0016787; Molecular function:hydrolase activity
GO:0008233; Molecular function:peptidase activity
GO:0004252; Molecular function:serine-type endopeptidase activity

Cross-references [?]

PROSITE PS00134; TRYPSIN_HIS; 1;
PROSITE PS00135; TRYPSIN_SER; 1;
PROSITE PS00134; TRYPSIN_HIS; 0-1;
PROSITE PS00135; TRYPSIN_SER; 0-1;

Features [?]

From: PS50240
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Peptidase S1 #"
ACT_SITE 42 42 /note="Charge relay system" H 1
ACT_SITE 91 91 /note="Charge relay system" D 1
ACT_SITE 186 186 /note="Charge relay system" S 1
DISULFID 27 43 disulf C-x*-C
DISULFID 125 192 disulf C-x*-C
DISULFID 156 171 disulf C-x*-C
DISULFID 182 210 disulf C-x*-C

Additional information [?]

Size range 150-286 amino acids
Related rules None
Fusion None
Repeats 1-2
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



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UniProtKB rule member sequences [?]