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annotation rule: PRU00274

General rule information [?]

Accession PRU00274
Dates 12-DEC-2003 (Created)
21-NOV-2019 (Last updated, Version 19)
Data class Domain
Predictors PROSITE; PS50240; TRYPSIN_DOM
Name Serine proteases, trypsin domain
Function Cleaves preferentially: Arg-|-Xaa, Lys-|-Xaa

Propagated annotation [?]


Description [?]

case <FTGroup:1>
+ RecName: EC 3.4.21.-;
end case


Comments [?]

Similarity Belongs to the peptidase S1 family.

Cross-references [?]

case <FTGroup:1>
PROSITE PS00134; TRYPSIN_HIS; 1;
PS00135; TRYPSIN_SER; 1;
else
PS00134; TRYPSIN_HIS; 0-1;
PS00135; TRYPSIN_SER; 0-1;
end case


Gene Ontology [?]

case <FTGroup:1>
GO:0016787; Molecular function: hydrolase activity.
GO:0008233; Molecular function: peptidase activity.
GO:0004252; Molecular function: serine-type endopeptidase activity.

Keywords [?]

Hydrolase
Protease
Serine protease
end case

case <FTTag:disulf>
Disulfide bond
end case


Features [?]

From: PS50240
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       Peptidase S1 #        
ACT_SITE     42     42       Charge relay system     H   1
ACT_SITE     91     91       Charge relay system     D   1
ACT_SITE     186     186       Charge relay system     S   1
DISULFID     27     43           disulf   C-x*-C  
DISULFID     125     192           disulf   C-x*-C  
DISULFID     156     171           disulf   C-x*-C  
DISULFID     182     210           disulf   C-x*-C  

Additional information [?]

Size range 150-286 amino acids
Related rules None
Repeats 1-2
Topology Undefined
Example Q9BYE2 (TMPSD_HUMAN)
Scope
Eukaryota
Bacteria

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.


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UniProtKB rule member sequences [?]