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ProRule PRU00274
General rule information
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Accession | PRU00274 |
Dates | 12-DEC-2003 (Created)
21-NOV-2019 (Last updated, Version 19) |
Data class | Domain; |
Predictors |
PROSITE; PS50240; TRYPSIN_DOM |
Name | Serine proteases, trypsin domain |
Function | Cleaves preferentially: Arg-|-Xaa, Lys-|-Xaa |
Scope(s) |
Eukaryota Bacteria |
Example(s) | Q9BYE2 (TMPSD_HUMAN); |
Propagated annotation
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Identifier, protein and gene names
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case <FTGroup:1> | |
Protein name | + RecName: EC=3.4.21.-; |
end case |
Comments
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SIMILARITY | Belongs to the peptidase S1 family. |
case <FTGroup:1> | |
case <FTGroup:1> |
Keywords
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Hydrolase | |
Protease | |
Serine protease | |
end case | |
case <FTTag:disulf> | |
Disulfide bond | |
end case |
Gene Ontology
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case <FTGroup:1> | |
case <FTGroup:1> | |
GO:0016787; Molecular function:hydrolase activity | |
GO:0008233; Molecular function:peptidase activity | |
GO:0004252; Molecular function:serine-type endopeptidase activity |
Cross-references
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PROSITE | PS00134; TRYPSIN_HIS; 1; |
PROSITE | PS00135; TRYPSIN_SER; 1; |
PROSITE | PS00134; TRYPSIN_HIS; 0-1; |
PROSITE | PS00135; TRYPSIN_SER; 0-1; |
Features
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From: PS50240 | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
DOMAIN | from | to | /note="Peptidase S1 #" | |||||||||
ACT_SITE | 42 | 42 | /note="Charge relay system" | H | 1 | |||||||
ACT_SITE | 91 | 91 | /note="Charge relay system" | D | 1 | |||||||
ACT_SITE | 186 | 186 | /note="Charge relay system" | S | 1 | |||||||
DISULFID | 27 | 43 | disulf | C-x*-C | ||||||||
DISULFID | 125 | 192 | disulf | C-x*-C | ||||||||
DISULFID | 156 | 171 | disulf | C-x*-C | ||||||||
DISULFID | 182 | 210 | disulf | C-x*-C |
Additional information
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Size range | 150-286 amino acids |
Related rules |
None |
Fusion | None |
Repeats | 1-2 |
Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Bacteria [9] Eukaryota [891] All [ 900 ]
- Retrieve set of proteins with 3D structure for this domain