annotation rule: PRU00275

General rule information [?]

Accession PRU00275
Dates 12-DEC-2003 (Created)
12-MAR-2018 (Last updated, Version 18)
Data class Domain
Predictors PROSITE; PS50175; ASP_PROT_RETROV
Name Eukaryotic and viral aspartyl proteases
Function Belongs to peptidase family A2

Propagated annotation [?]


Description [?]

case <OS:Human immunodeficiency virus 1> and <FTTag:act_site>
+ RecName: EC=3.4.23.16;
else case <OS:Human immunodeficiency virus 2> and <FTTag:act_site>
+ RecName: EC=3.4.23.47;
else case <FTTag:act_site>
+ RecName: EC=3.4.23.-;
end case


Comments [?]

case <OS:Human immunodeficiency virus 1>
Function The aspartyl protease mediates proteolytic cleavages of Gag and Gag-Pol polyproteins during or shortly after the release of the virion from the plasma membrane. Cleavages take place as an ordered, step-wise cascade to yield mature proteins. This process is called maturation. Displays maximal activity during the budding process just prior to particle release from the cell. Also cleaves Nef and Vif, probably concomitantly with viral structural proteins on maturation of virus particles.
else case <OC:Retroviridae>
Function The aspartyl protease mediates proteolytic cleavages of Gag and Gag-Pol polyproteins during or shortly after the release of the virion from the plasma membrane. Cleavages take place as an ordered, step-wise cascade to yield mature proteins. This process is called maturation. Displays maximal activity during the budding process just prior to particle release from the cell.
end case

case <OS:Human immunodeficiency virus 1> and <FTTag:act_site>
Catalytic activity Specific for a P1 residue that is hydrophobic, and P1' variable, but often Pro.
else case <OS:Human immunodeficiency virus 2> and <FTTag:act_site>
Catalytic activity Endopeptidase for which the P1 residue is preferably hydrophobic.
end case


Cross-references [?]

PROSITE PS00141; ASP_PROTEASE; 1;

Gene Ontology [?]

case <FTTag:act_site>
GO:0004190; Molecular function: aspartic-type endopeptidase activity.
GO:0016787; Molecular function: hydrolase activity.
GO:0008233; Molecular function: peptidase activity.

Keywords [?]

end case


Features [?]

From: PS50175
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       Peptidase A2 #        
case <OC:Retroviridae>
ACT_SITE     6     6       Protease; shared with dimeric partner   act_site   D  
else
ACT_SITE     6     6       @TARGET_ACTIVITY_VISIBILITY|For protease activity@   act_site   D  
end case


Additional information [?]

Size range 40-82 amino acids
Related rules None
Repeats 1
Topology Undefined
Example P51518 (PRO_SRV2)
Scope Eukaryota
Viruses

Copyright

PROSITE is copyright. It is produced by the SIB Swiss Institute Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified. Usage by and for commercial entities requires a license agreement. For information about the licensing scheme send an email to license@isb-sib.ch or see: prosite_license.html.



UniProtKB rule member sequences [?]